Anna Łabno

ORCID: 0000-0002-2669-2733
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About
Contact & Profiles
Research Areas
  • Polish Law and Legal System
  • RNA Research and Splicing
  • Polish Historical and Cultural Studies
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • European and International Law Studies
  • PI3K/AKT/mTOR signaling in cancer
  • Global Health Care Issues
  • Polish Legal and Social Issues
  • RNA regulation and disease
  • Intellectual Property Rights and Media
  • Theology and Canon Law Studies
  • RNA and protein synthesis mechanisms
  • DNA Repair Mechanisms
  • Health Services Management and Policy
  • Local Governance and Planning
  • Carcinogens and Genotoxicity Assessment
  • Plant Pathogens and Resistance
  • Agriculture, Plant Science, Crop Management
  • Extracellular vesicles in disease
  • European Union Policy and Governance
  • Circular RNAs in diseases
  • Language and Culture
  • Ombudsman and Human Rights

Polska Grupa Górnicza (Poland)
2019

University of Silesia in Katowice
2018

Andrzej Frycz Modrzewski Krakow University
2017

Centrum Onkologii
2017

Jagiellonian University
2017

University of Warsaw
2015-2016

Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2015-2016

Human DIS3, the nuclear catalytic subunit of exosome complex, contains exonucleolytic and endonucleolytic active domains. To identify DIS3 targets genome-wide, we combined comprehensive transcriptomic analyses engineered HEK293 cells that expressed mutant with Photoactivatable Ribonucleoside-Enhanced Cross-Linking Immunoprecipitation (PAR-CLIP) experiments. In expressing both sites mutated, RNAs originating from unannotated genomic regions increased ∼2.5-fold, covering ∼70% genome allowing...

10.1101/gr.189597.115 article EN cc-by-nc Genome Research 2015-08-20

The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel substrates human cells. We show that regulates pol II transcripts, comprising selected canonical histone-coding mRNAs, a FTL_short RNA from the ferritin mRNA 5' UTR. Importantly, contributes surveillance of maturing snRNAs during their cytoplasmic processing. Among III particularly targets vault Y RNAs an Alu-like...

10.1093/nar/gkw649 article EN cc-by-nc Nucleic Acids Research 2016-07-18

Production of ribosomes relies on more than 200 accessory factors to ensure the proper sequence steps and faultless assembly ribonucleoprotein machinery. Among trans-acting are numerous enzymes, including ribonucleases responsible for processing large rRNA precursor synthesized by RNA polymerase I that encompasses sequences corresponding mature 18S, 5.8S, 25/28S rRNA. In humans, identity most enzymes individual steps, endoribonucleases cleave pre-rRNA at specific sites within regions...

10.1080/15476286.2015.1073437 article EN RNA Biology 2015-08-03

Celem niniejszego opracowania jest rozważenie wysuwanego postulatu, by Unia Europejska odstąpiła od zamiaru wymuszenia na państwach członkowskich spełnienia warunków praworządności materialnej. Miałoby to, jak można sądzić, doprowadzić do utrzymania i utrwalenia spoistości Unii poprzez wykluczenie dalszego jej upolityczniania oraz przede wszystkim umożliwić zachowanie tożsamości krajów członkowskich. Powstaje jednakże fundamentalne pytanie, czy forsowana w koncepcja właśnie tym celem,...

10.37873/legal.2023.6.120 article PL cc-by-sa The Legal Culture 2023-12-29

Ustawa o szkolnictwie wyższym i nauce z 2018 r. w poważnym stopniu ogranicza autonomię wewnętrzną uczelni. Zarządzanie oddaje ręce rektora rady uczelni a pomija wydziały, które, ile ogóle będą powołane, zostały sprowadzone do roli podmiotów bez istotnego znaczenia. Rektor jako wyłączny kierowniczy organ rada uczelni, reprezentująca przede wszystkim interesariuszy zewnętrznych, nadzoru nad jej gospodarką, uzyskali tak szerokie kompetencje, że konsekwencji może to wpływać negatywnie na rozwój...

10.7206/kp.2080-1084.198 article PL cc-by Krytyka Prawa 2018-06-15

The Act on Higher Education and Science of 2018 considerably restricts the internal autonomy universities. Management is vested in rectors university boards while neglecting role faculties, which, if established first place, have been reduced to entities no significance. rector, as exclusive managerial body an institution, board, representing mainly external stakeholders, a supervising its economy, with such ex-tensive authority that this may result hindering development multiple academic...

10.7206/kp.2080-1084.199 article EN cc-by Krytyka Prawa 2018-06-15
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