A5069121965- Advanced Radiotherapy Techniques
- Cancer Treatment and Pharmacology
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Cancer therapeutics and mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neurological disorders and treatments
- Effects of Radiation Exposure
- Colorectal Cancer Treatments and Studies
- Cerebrovascular and Carotid Artery Diseases
- Metastasis and carcinoma case studies
- Clusterin in disease pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Anatomy and Medical Technology
- Sarcoma Diagnosis and Treatment
- Machine Learning in Bioinformatics
- Amino Acid Enzymes and Metabolism
- Systemic Sclerosis and Related Diseases
- Advanced Neuroimaging Techniques and Applications
- Ovarian cancer diagnosis and treatment
- Genomics and Rare Diseases
- Oral health in cancer treatment
Hôpital de la Timone
2021-2023
Assistance Publique Hôpitaux de Marseille
2023
Institut de Neurosciences des Systèmes
2021
Hôpital Edouard Herriot
2004-2012
Hôpital Lyon Sud
2012
BC Cancer Agency
2007
Hôpital Louis Pradel
1984-2004
Centre Léon Bérard
2004
Hôpital de la Croix-Rousse
2004
Hôpital Saint Joseph
2004
OBJECTIVE The tremor circuitry has commonly been hypothesized to be driven by one or multiple pacemakers within the cerebello-thalamo-cortical pathway, including cerebellum, contralateral motor thalamus, and primary cortex. However, previous studies, using methodologies, have advocated that could influenced changes right extrastriate cortex, at both structural functional level. purpose of this work was evaluate role cortex in generation further arrest after left unilateral stereotactic...
Abstract Purpose . Since January 2021, the Leksell ® Vantage head frame (V-frame) is used for Gamma Knife treatments in addition to historical G-Frame known as reference. The aim of this study was compare spatial accuracy with these two frames. Methods Firstly, constancy geometric system according Elekta quality assurance process carried out during sixteen months V and G–frames’ adaptors. Then, End-to-end test both G-frame using an anthropomorphic phantom Gafchromic films. overall precision...
OBJECTIVE Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic deep brain stimulation or radiofrequency thalamotomy or, alternatively, minimally invasive techniques, including radiosurgery (SRS) and high-intensity focused ultrasound, at level of ventral intermediate nucleus (Vim). The aim present study was to evaluate potential correlations between pretherapeutic interconnectivity (IC), as depicted on resting-state functional...
<b><i>Background:</i></b> Radiosurgery is performed with a diversity of instruments relying usually either on stereotactic frame or mask for patient head fixation. Comfort and safety efficacy the 2 systems have never been rigorously evaluated compared. <b><i>Material Method:</i></b> Between February 2016 January 2017, 58 patients presenting nonsmall cell lung cancer brain metastases treated by Gamma Knife radiosurgery (GKS) random use fixation...
7596 Background: OGX-011 is a second-generation antisense oligonucleotide designed to knockdown expression of the cytoprotective chaperone, clusterin, thereby facilitating apoptosis and sensitization many human cancer cell-lines chemotherapy. Methods: Eligibility criteria: stage IIIB/IV NSCLC; no prior chemotherapy; =1 measurable lesion; ECOG =1; adequate organ function; active CNS metastasis. Treatment: infusion initial loading doses (3 in 1 week), followed by weekly with standard...
3109 Background: The ubiquitinin-proteosome proteolytic pathway regulates the metabolism of critical proteins involved in cell cycle, apoptosis and metastasis such as p53, p21, p27 NFκB. PS341(Bortezomib; Velcade) is a specific selective inhibitor 26S proteosome. PS341 results significant regression human colon cancer xenograft model. Methods: This phase II study aimed to assess activity patients with metastatic colorectal who had received no more than 1 prior line chemotherapy irinotecan...
4669 Background: AGS-1C4D4 is a fully human MAb directed to PSCA, cell surface antigen expressed on tumor cells in the majority of patients with prostate, pancreatic and bladder cancers. produced CHO has an identical sequence that hybridoma-derived AGS-PSCA. Preclinical studies confirmed comparability AGS-PSCA inhibition tissue cross reactivity PK. Due differences glycosylation ADCC vitro, limited phase I trial was undertaken explore potential safety Methods: Thirteen metastatic CRPC were...
202 Background: Several studies are in favor of an α/β ratio less than 3Gy for prostate (P) cancer, encouraging HFR. However, the development such radiation patterns can only be done if risk rectal toxicity is well controlled. The objective present study was to evaluate contribution injection HA between rectum and P reduce a HFR approach. Methods: A phase II at 62Gy 20 fractions (BED = 84Gy; α / β 1.5Gy) currently conducted. transperineal 10cc (NASHA Spacer gel, Q-Med AB, Uppsala, Sweden)...
7079 Background: Radiation pneumonitis (RP) is the toxicity of 3D-CRT in irradiated patients. The goals this study were to evaluate predictive value circulating cytokines levels before, during and after for risk radiation patients (pts) with NSCLC. Methods: 96 pts receiving stage IA-IIIB evaluated. Serum IL-6, IL-10, TNFα TGFβ1 measured using specific ELISAs every 2 weeks (w.) months (m.) 3D-CRT. RP was diagnosed m. Lent-Soma score. All reviewed by independent panel. A repeated measures...