A5053470815- Glioma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Cardiac Arrest and Resuscitation
- Cerebrospinal fluid and hydrocephalus
- Cancer Cells and Metastasis
- Shoulder Injury and Treatment
- Trigeminal Neuralgia and Treatments
- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Intracranial Aneurysms: Treatment and Complications
- Brain Metastases and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Facial Nerve Paralysis Treatment and Research
- Shoulder and Clavicle Injuries
- Neurosurgical Procedures and Complications
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Cardiovascular Syncope and Autonomic Disorders
- Pituitary Gland Disorders and Treatments
- Cancer Treatment and Pharmacology
- Migraine and Headache Studies
- Cerebral Venous Sinus Thrombosis
AdventHealth Orlando
2010-2025
University of Central Florida
2010-2023
Florida College
2010-2023
Center for Independent Living
2023
Florida Hospital Cancer Institute
2023
Orlando Health
2012-2022
Oxford University Press (United Kingdom)
2018-2020
Neurological Surgery
2001-2019
Duke University Hospital
2019
University of Kansas Medical Center
2019
A computerized neuropsychological test battery was conducted to evaluate memory dysfunction and self-reporting of symptoms in a group high school athletes who had suffered concussion.Neuropsychological performance prior following concussion compared with the an age-matched control group. Potentially important diagnostic markers severity are discussed linked recovery within 1st week injury.High mild demonstrated significant declines processes relative noninjured Statistically differences...
A common assumption in sports medicine is that a history of concussion predictive lower threshold for, as well worse outcome after, subsequent concussive injury. The current study was conducted to investigate the relationship between high school athletes and on-field presentation symptoms after concussion.One hundred seventy-three who experienced sports-related composed initial group. Binary groups were subsequently created on basis history. Sixty with no compared 28 three or more...
Background/Objectives: Glioblastoma (GBM), a highly aggressive grade IV astrocytoma, poses major therapeutic challenge due to the resistance of cancer stem cells (CSCs) existing within its cell population conventional therapies. Recently, we reported that RNA interference targeting CSC protection mechanism significantly improved efficacy. However, challenges remain, including limited transfection efficiency in neural and difficulty crossing blood–brain barrier (BBB). Methods: In this study,...
Background: The relevance of headache to outcome after sports-related concussion is poorly understood. Hypotheses: High school athletes reporting approximately 1 week injury will have significantly more other symptoms and perform on neuropsychological tests than not experiencing headache. Study Design: Prospective cohort study. Methods: participants included 109 high who had sustained were divided into two groups: those 7 days no headaches. groups compared regarding on-field markers severity...
Object. Stereotactic brain biopsy has played an integral role in the diagnosis and management of lesions. At most centers, imaging studies following are rarely performed. The authors prospectively determined acute hemorrhage rate after stereotactic by performing immediate postbiopsy intraoperative computerized tomography (CT) scanning. They then analyzed factors that may influence risk diagnostic accuracy rate. Methods. Five hundred consecutive patients undergoing underwent CT Before...
The object of this study was to compare symptom status and neurocognitive functioning in athletes with no headache (non-HA group), complaining (HA characteristics posttraumatic migraine (PTM group).Neurocognitive tests were undertaken by 261 high-school collegiate a mean age 16.36 +/- 2.6 years. Athletes separated into three groups: the PTM group (74 16.39 3.06 years), HA (124 16.44 2.51 non-HA (63 patients 16.14 2.18 years). Neurocognitive summary scores (outcome measures) for verbal visual...
Glioblastoma (GBM) is an aggressive and incurable primary brain tumor that harbors therapy-resistant cancer stem cells (CSCs). Due to the limited effectiveness of conventional chemotherapies radiation treatments against CSCs, there a critical need for development innovative therapeutic approaches. Our previous research revealed significant expression embryonic stemness genes, NANOG OCT4, in suggesting their role enhancing cancer-specific drug resistance. In our current study, we employed RNA...
Stereotactic laser ablation (SLA), also termed interstitial thermal therapy, is a minimally invasive procedure that increasingly used in neurosurgery. We wished to examine how and whether SLA changing the landscape of treatment options for neurosurgical patients. Patients undergoing stereotactic were prospectively enrolled Laser Ablation Abnormal Neurological Tissue (LAANTERN) registry. Data from first 100 patients are presented here. Clinical indications include primary intracranial tumors...
Stereotactic laser ablation (SLA) has demonstrated potential utility for a spectrum of difficult to treat neurosurgical pathologies in multiple small and/or retrospective single-institutional series. Here, we present the safety profile SLA intracranial lesions from Laser Ablation Abnormal Neurological Tissue using Robotic NeuroBlate System (LAANTERN; Monteris Medical) multi-institutional, international prospective observational registry.To determine procedural lesions.Prospective and...
Glioblastoma multiforme (GBM) possesses a small but significant population of cancer stem cells (CSCs) thought to play role in its invasiveness, recurrence, and metastasis. The CSCs display transcriptional profiles for multipotency, self-renewal, tumorigenesis, therapy resistance. There are two possible theories regarding the origin context neural (NSCs); i.e., NSCs modify by conferring them with cancer-specific stemness, or themselves transformed into due tumor environment created cells. To...
no published evidence indicates when patients can resume golfing after spine surgery. The objective of this study is to provide data from surveys sent surgeons.a survey North American Spine Society members was undertaken querying the suggested timing return golf. Of 1000 surgeons surveyed, 523 responded (52.3%). recommended golf and reasons were questioned for college/professional athletes avid recreational golfers both sexes. Responses tallied lumbar laminectomy, microdiscectomy, fusion,...
Approximately 136,000 concussions occur annually in American high school sports. Neuropsychological data indicate that children with preexisting cognitive difficulties, such as attention-deficit hyperactivity disorder (ADHD), may have protracted recovery from concussion. ADHD, an estimated prevalence of 11% youth, increase athlete's vulnerability to sustaining sports-related traumatic brain injury (TBI). The preponderance evidence focusing on TBI and ADHD has derived motor vehicle accidents...
Exosomes participate in intercellular communication by transporting functionally active molecules. Such cargo from the original cells comprising proteins, micro-RNA, mRNA, single-stranded (ssDNA) and double-stranded DNA (dsDNA) molecules pleiotropically transforms target cells. Although cancer secrete exosomes carrying a significant level of capable modulating oncogene expression recipient cell, regulatory mechanism is unknown. We have previously reported that produce containing NANOGP8 DNA....
Ubiquitin; there is no doubt that ubiquitin a "lucky" protein. It lucky in many ways: for scientific progress, biomedical scientists and life! If you have not already done so, why don't get look role your experimental system. As Avram Hershko has said "there plently to go around"! (Previousy quoted by Mayer et al. [1].)
Emergency percutaneous ventriculostomy is one of the most common and potentially life-saving therapeutic procedures performed in neurosurgical practice. We report first case development an iatrogenic dural arteriovenous fistula (DAVF) after emergency drain (EVD) placement. This 64-year-old woman, who presented with intraventricular hemorrhage hydrocephalus, underwent bedside right frontal twist-drill trocar puncture. Diagnostic cerebral angiography was revealed a DAVF middle meningeal artery...
Gamma Knife® (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness in metastases cancers.An IRB-approved database was queried gynecologic cancers between June 1996 and May 2016. Imaging studies were reviewed post-SRS (stereotactic radiosurgery) evaluate local control (LC) distant (DC). Overall survival...