Major depressive disorder (MDD) is conventionally diagnosed through a questionnaire. Since approaches to diagnose MDD may lead inaccurate diagnoses, many studies have presented electroencephalogram (EEG)-based machine learning techniques. The present paper introduces deep approach based on image construction from EEGs. Two images are constructed EEGs spectral and functional connectivity features. Afterward, the applied two-stream convolutional neural network, outputs concatenated. Finally,...

Extracellular beta-amyloid (Aβ) accumulation and deposition is the main factor, which causes synaptic loss eventually cells death in Alzheimer's disease (AD). Memory long-term potentiation (LTP) dysfunction hippocampus are involved AD. The involvement of crocin, as active constituent saffron extract learning memory processes, has been proposed. Here we investigated probable therapeutic effect crocin on memory, LTP, neuronal apoptosis using vivo Aβ models peptide (1-42) was bilaterally...

Objectives: To employ different automated convolutional neural network (CNN)-based transfer learning (TL) methods for both binary and multiclass classification of Alzheimer’s disease (AD) using brain MRI. Methods: Herein, we applied three popular pre-trained CNN models (ResNet101, Xception, InceptionV3) a fine-tuned approach TL on 3D T 1-weighted MRI from subset ADNI dataset (n = 305 subjects). evaluate power TL, the aforementioned networks were also trained scratch performance comparison....

In this study, the cardiovascular system and heart hemodynamic performance are modeled using lumped method (electrical analogy) to evaluate effects of abnormal heartbeats on performance. Lumped (voltage–current relations an electrical circuit) is able simulate (CV) behavior in various physiological conditions. CV consists 42 compartments, including artery, vein, capillary set, chambers. Each blood circulatory subsystem (compartment) elements, such as resistor, capacitor, inductor. by...

Objectives Saffron (Crocus sativus L.) has been widely used in traditional medicine as a treatment of nervous disorders. an antioxidant can be considered effective for oxidative stress ischemia stroke. Therefore, the aim present study was to investigate role aqueous extract saffron reducing ischemic strokes patients.Methods Forty patients with acute stroke were randomly divided into two groups including control group and group. During 4 days experiment, received routine care plus capsule 400...

Brain-derived neurotrophic factor (BDNF) and high sensitive C-reactive protein (hs-CRP) have been reported to play roles in depression bipolar disorder (BD). However, the probable discriminatory properties of these biologic markers are less investigated. We aimed assess serum BDNF hs-CRP levels among Iranian patients with major depressive (MDD) BD during a episode investigate optimum cut-off point for differential diagnosis MDD.We recruited 30 MDD, mood healthy comparators. Blood sample was...

Alzheimer's disease (AD) is a neurodegenerative that results in the gradual breakdown of brain tissue, causing deterioration intellectual function and ability. Crocin saffron carotenoid compound proven to have excellent neuroprotective anti-inflammation properties, although it has some limitations such as low stability bioavailability. Therefore, current research, we tried improve these by using nanotechnology chitosan carrier. Our study examined therapeutic effects crocin...

Summary Despite extensive research over the years, there still exists some debate as to what constitutes optimal therapeutic strategy promote recovery following stroke. Due complexity of injured brain pathophysiology, treatment approaches should ideally address numerous factors, ultimately aiming tissue protection, axonal regrowth and functional recovery. This study extends understanding effects bone marrow stromal cell ( BMSC ) experimentally induced ischemic stroke in rats. Focal injury...

Objective: Post-traumatic stress disorder (PTSD) as one of the most devastating kinds anxiety disorders, is consequence a traumatic event. Crocus sativus L., commonly known saffron have been traditionally used for treatment and anxiety. In this study, we evaluated effects peripheral administration saffron, along with deep brain stimulation (DBS) in post-traumatic model caused by contextual fear conditioning (electrical foot shock chamber) male Wistar rats. Materials Methods: rats (220-250 g)...

Creatine is a nutritional compound that potentially influences cognitive processing and neuroprotection. Recent evidence has demonstrated similar to neurotransmitters, creatine released in an excitotoxic action potential-dependent manner acts as neuromodulator. deficiency syndromes are characterized by severe mental developmental disorders. Studies have reported brain content could be enhanced with supplementation. Nevertheless, there still limited knowledge about the effects of on central...

Sulfur mustard (SM) is an alkylating agent that induces apoptosis and necrosis in cells. Fas-Fas ligand (FasL) interaction could induce as well. In this study, it was hypothesized might play important role the pathogenesis of SM-induced lung injury via Fas-FasL signaling pathway. a case-control Fas FasL levels, caspase-3 activity percent apoptotic cells were measured bronchoalveolar lavage (BAL) fluid patients 20 years after exposure to sulfur compared with control group. Results show levels...

Abstract In this study, we investigated the therapeutic effects of simvastatin administered in combination with bone marrow stromal cells ( BMSC s) following experimentally induced embolic stroke rats. Effects on infarct volume, brain oedema and neurological deficits were examined. Focal ischaemic injury was by emblazing a preformed clot into middle cerebral artery Animals (40 mg/kg) at 1 hr after stroke, or s (3 × 10 6 ) 24 these two treatments. Rats receiving dose administration...

Posttraumatic stress disorder (PTSD) occurs following life threatening events. The activity of hypothalamic-pituitary-adrenal (HPA) axis, which serves as the first line defense against stress, is damaged in disorder. current study aimed to investigate role crocin improvement HPA function animal model PTSD induced by electric foot shock. Rats treated with 5 minutes prior induction stress. Samples were placed again communication box after 21 days, re-experience and we followed individual...