A5067789116- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Animal Virus Infections Studies
- Coccidia and coccidiosis research
- Respiratory viral infections research
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Essential Oils and Antimicrobial Activity
- RNA Interference and Gene Delivery
- Psidium guajava Extracts and Applications
- Veterinary medicine and infectious diseases
- COVID-19 epidemiological studies
- Medicinal Plant Research
- T-cell and Retrovirus Studies
- Infectious Encephalopathies and Encephalitis
- Medicinal Plant Extracts Effects
- COVID-19 impact on air quality
- Attention Deficit Hyperactivity Disorder
Baqiyatallah University of Medical Sciences
2014-2025
Tarbiat Modares University
2021-2022
Bi- or tri-specific T cell engagers (BiTE TriTE) are recombinant bispecific proteins designed to stimulate T-cell immunity directly, bypassing antigen presentation by antigen-presenting cells (APCs). However, these molecules suffer from limitations such as short biological half-life and poor residence time in the tumor microenvironment (TME). Fortunately, challenges can be overcome when combined with OVs. Various strategies have been developed, encoding secretory BiTEs within OV vectors,...
In the present study, zinc oxide (ZnO) and iron (FeO) nanoparticles were examined for their possible, in vitro anthelmintic effects against Toxocara vitulorum. The worms incubated 24 h with different concentrations (0.004, 0.008 0.012% w/v) of nanoparticles. parasite mobility, mortality, superoxide dismutase (SOD) activity, malondialdehyde (MDA) nitric (NO) level recorded at time intervals. results showed that both could significantly decrease worm's increase mortality rate as well elevate...
Posttraumatic stress disorder (PTSD) occurs following life threatening events. The activity of hypothalamic-pituitary-adrenal (HPA) axis, which serves as the first line defense against stress, is damaged in disorder. current study aimed to investigate role crocin improvement HPA function animal model PTSD induced by electric foot shock. Rats treated with 5 minutes prior induction stress. Samples were placed again communication box after 21 days, re-experience and we followed individual...
Coronaviruses (CoVs) are large ribonucleic acid (RNA) viruses causing primarily respiratory disease in humans. A novel human coronavirus, subsequently named middle east syndrome coronavirus (MERS-CoV), was first reported Saudi Arabia September of 2012. With increasing numbers infections and deaths from MERS-CoV, development a rapid reliable kit crucial to prevent further spread MERS-CoV.In this study, we present two real-time reverse-transcription polymerase chain reaction (rRT-PCR) assays...
At the forefront of biopharmaceutical industry, messenger RNA (mRNA) technology offers a flexible and scalable platform to address urgent need for world-wide immunization in pandemic situations. This strategic powerful has recently been used immunize millions people proving both safety highest level clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report COReNAPCIN®; vaccine candidate SARS-CoV-2 infection....
Background: Puma is a highly robust pro-apoptotic protein. The protein becomes activated by p53 ensuing beyond-repair DNA damage. Downregulation of SIRT 1, miR-128, elevates that foment indirectly. Objectives: In the present study, we used two-expression Adeno-Associated Virus (AAV) system for co-expression miR-128 and in order to evaluate apoptotic response; both tumor normal cells, respectively. Materials Methods: Three recombinant AAVs constructs were generated. First rAAV bearing under...
The Crimean-Congo hemorrhagic fever (CCHF) virus causes severe disease in humans, with a high mortality rate. Since, there is no approved vaccine or specific treatment for CCHF, an early and accurate diagnosis, as well reliable surveillance, essential case management patient improvement.For this research, our aim was to evaluate the application of novel SYBR Green based one-step real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) assay in-house diagnosis CCHF virus.In...
Lentiviral gene delivery is now considered as a major candidate in the future of cancer therapy. To avoid common side-effects associated with methods therapy, survivin promoter shows great promise due to its high expression level multiple cancers. In this research, using 2A peptide, Noxa was coexpressed hemagglutinin neuraminidase (HN) driven by (Surp). Coding genes and HN were connected upstream downstream peptide SOE PCR. After cloning Noxa-2A-HN Surp into lentiviral vector, final...
Prokaryotic Expression of Influenza A virus Nucleoprotein Fused to Mycobacterial Heat Shock Protein70
Background & objectives: West Nile virus (WNV) is a positive-sense, single-stranded RNA virion, that belongs to the Flaviviridae family. This preserved in bird-mosquito cycle capable of inducing diseases as dead-end or endpoint host humans well horses. In 2016, suspicious case crow population death was reported by Department Environment, Ministry Health, Iran. Considering mass migration birds together with WNV-related symptoms, including uncoordinated walking, ataxia, inability fly, lack...
Abstract Background Immunotherapy, during which the immune system of patient is manipulated to act against tumors has been among most successful methods in treatment breast cancer, a leading cause mortality women worldwide. Objectives To investigate immunotherapeutic efficacy Lactobacillus casei lysate as an adjuvant combination with heated-4T1 mammary carcinoma cell model cancer. Methods After ethics committee approval all animal procedures, murine cancer was induced BALB/c mice using 4T1...
Recently, respiratory viral infections have witnessed substantial diagnostic evolution, with the advent of emergent pathogenic agents and improvement new approaches. Acute infection (ARVI) commonly causes illness fatality, particularly in pediatric patients. Adenovirus has highest prevalence upper lower tract (RTIs) amongst pathogens importance. The purpose this research was to introduce two effective techniques for detection adenovirus Human samples, cell culture, real-time PCR. Samples...