A5072332400- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Time Series Analysis and Forecasting
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Anomaly Detection Techniques and Applications
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
Children's Medical Center
2022-2024
Tehran University of Medical Sciences
2022-2024
Abstract Most eukaryotic mRNAs and different non‐coding RNAs undergo a form of 3′ end processing known as polyadenylation. Polyadenylation machinery is present in almost all organisms except few species. In bacteria, the has evolved from PNPase, which adds heteropolymeric tails, to poly(A)‐specific polymerase. Differently, complex for accurate polyadenylation several non‐canonical poly(A) polymerases are developed eukaryotes. The role tail also serving degradative signal stabilizing...
At the forefront of biopharmaceutical industry, messenger RNA (mRNA) technology offers a flexible and scalable platform to address urgent need for world-wide immunization in pandemic situations. This strategic powerful has recently been used immunize millions people proving both safety highest level clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report COReNAPCIN®; vaccine candidate SARS-CoV-2 infection....
Chimeric antigen receptor natural killer (CAR-NK) cell therapy is recognized as a promising modality for the treatment of hematologic malignancies, particularly B-cell malignancies. In this study, we developed ''off-the-shelf'' anti-CD19 CAR-NK cells using CAR mRNAs formulated in proprietary ionizable lipid nanoparticles (LNPs). The efficiency mRNA-LNP delivery into umbilical cord blood (UCB)-derived NK and primary T was evaluated an in-vitro setting, demonstrating superior cells. Further...
The RoboCup competitions hold various leagues, and the Soccer Simulation 2D League is a major among them. (SS2D) match involves two teams, including 11 players coach for each team, competing against other. can only communicate with Server during game. Several code bases are released publicly to simplify team development. So researchers easily focus on decision-making implementing machine learning methods. SS2D actions behaviors partially accurate due different challenges, such as noise...
The repeated COVID-19 outbreaks, despite global vaccination, highlights the need for booster doses. Here, we present outcomes, up until day 90 post of a randomized, double-blind, placebo-controlled phase 1 clinical trial mRNA-based vaccine candidate; COReNAPCIN ® , as dose in adults aged 18-50 who had previously received three doses inactivated vaccines. In study, 30 participants randomly (2:2:1) 25 μg, or 50 μg placebo. results indicated that was well tolerated vaccinated individuals both...
At the forefront of biopharmaceutical industry, messenger RNA (mRNA) technology offers a flexible and scalable platform to address urgent need for world-wide immunization in pandemic situations. This strategic powerful has recently been used immunize millions people proving both safety highest level clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report COReNAPCIN ® ; vaccine candidate SARS-CoV-2 infection. is...