A5060355847- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Infant Nutrition and Health
- Animal Genetics and Reproduction
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Cancer-related gene regulation
- Colorectal Cancer Screening and Detection
- Smart Materials for Construction
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Transgenic Plants and Applications
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Viral Infections and Immunology Research
University of Utah
2009-2018
Huntsman Cancer Institute
2009-2018
Pasteur Institute of Iran
2005
Background Sessile serrated polyps (SSPs) have emerged as important precursors for a large number of sporadic colorectal cancers. They are difficult to detect during colonoscopy due their flat shape and the excessive amounts secreted mucin that cover polyps. The underlying genetic epigenetic basis emergence SSPs is largely unknown with existing studies confined limited oncogenes tumor suppressors. A full characterization landscape would provide insight into origin potentially offer new...
At the forefront of biopharmaceutical industry, messenger RNA (mRNA) technology offers a flexible and scalable platform to address urgent need for world-wide immunization in pandemic situations. This strategic powerful has recently been used immunize millions people proving both safety highest level clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report COReNAPCIN®; vaccine candidate SARS-CoV-2 infection....
Chimeric antigen receptor natural killer (CAR-NK) cell therapy is recognized as a promising modality for the treatment of hematologic malignancies, particularly B-cell malignancies. In this study, we developed ''off-the-shelf'' anti-CD19 CAR-NK cells using CAR mRNAs formulated in proprietary ionizable lipid nanoparticles (LNPs). The efficiency mRNA-LNP delivery into umbilical cord blood (UCB)-derived NK and primary T was evaluated an in-vitro setting, demonstrating superior cells. Further...
The repeated COVID-19 outbreaks, despite global vaccination, highlights the need for booster doses. Here, we present outcomes, up until day 90 post of a randomized, double-blind, placebo-controlled phase 1 clinical trial mRNA-based vaccine candidate; COReNAPCIN ® , as dose in adults aged 18-50 who had previously received three doses inactivated vaccines. In study, 30 participants randomly (2:2:1) 25 μg, or 50 μg placebo. results indicated that was well tolerated vaccinated individuals both...
At the forefront of biopharmaceutical industry, messenger RNA (mRNA) technology offers a flexible and scalable platform to address urgent need for world-wide immunization in pandemic situations. This strategic powerful has recently been used immunize millions people proving both safety highest level clinical efficacy against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here we provide preclinical report COReNAPCIN ® ; vaccine candidate SARS-CoV-2 infection. is...