A5057755011- Virus-based gene therapy research
- Mesenchymal stem cell research
- SARS-CoV-2 and COVID-19 Research
- RNA Interference and Gene Delivery
- Animal Virus Infections Studies
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- CAR-T cell therapy research
- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- Bacteriophages and microbial interactions
- Pharmacological Effects of Natural Compounds
- Natural product bioactivities and synthesis
- interferon and immune responses
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Hydrogen's biological and therapeutic effects
- Medical and Biological Ozone Research
- Essential Oils and Antimicrobial Activity
- Probiotics and Fermented Foods
- Viral Infectious Diseases and Gene Expression in Insects
Baqiyatallah University of Medical Sciences
2019-2025
Biotechnology Research Center
2020
Tehran University of Medical Sciences
2020
Urmia University of Medical Sciences
2015-2018
Urmia University
2014-2018
Bi- or tri-specific T cell engagers (BiTE TriTE) are recombinant bispecific proteins designed to stimulate T-cell immunity directly, bypassing antigen presentation by antigen-presenting cells (APCs). However, these molecules suffer from limitations such as short biological half-life and poor residence time in the tumor microenvironment (TME). Fortunately, challenges can be overcome when combined with OVs. Various strategies have been developed, encoding secretory BiTEs within OV vectors,...
Introduction Multidrug-resistant (MDR) pathogens are being recognized as a critical threat to human health if they can form biofilm and, in this sense, biofilm-forming MDR-methicillin resistant Staphylococcus aureus (MRSA) and - Pseudomonas aeruginosa strains worse concern. Hence, growing body of documents has introduced antimicrobial peptides (AMPs) substitute candidate for conventional agents against drug-resistant biofilm-associated infections. We evaluated melittin’s antibacterial...
Fatty liver disease is commonly associated with inflammation, oxidative stress and apoptosis of hepatocytes. This study was designed to investigate the combinational therapeutic effects curcumin (CMN) Ursodeoxycholic acid (UDCA) on non-alcoholic fatty (NAFLD). Male Wistar rats were divided into 8 groups: NAFLD-induced rats, + CMN, UDCA, that received CMN UDCA. (200 mg/kg) UDCA (80 administered orally for 14 28 consecutive days. Biochemical histopathological analysis conducted in all groups....
The present study was undertaken to evaluate the synergistic effect of combining hyperthermia with irradiation and calcium carbonate nanoparticles (CC NPs) on proliferation MCF-7 cells. cells were randomly allocated 19 groups: one negative control, three positive controls 15 treatment groups. treated concentrations CC NPs (50, 100 150 μg/mL), gamma radiation (200 cGy), (41 °C for 1 h) doxorubicin (200, 400 800 nm) incubated at 37 24 h. Then cell viability, percentage apoptosis levels...
Abstract Aim: To evaluate the clinical efficacy of adjuvant use melatonin in patients with coronavirus disease 2019 (COVID-19). Methods: This single-center, double-blind, randomized trial included 74 hospitalized confirmed mild to moderate COVID-19 at Baqiyatallah Hospital Tehran, Iran, from April 25, 2020 June 5, 2020. Patients were randomly assigned a 1:1 ratio receive standard care and plus dose 3 mg three times daily for 14 days. Clinical characteristics, laboratory, radiological...
The inflammasome as a multiprotein complex has role in activating ASC and caspase-1 resulting IL-1β various infections diseases like corona virus infection tissues. It was shown that these tissues are affected by COVID-19 patients. According to the current evidence, melatonin is not veridical while possessing high safety profile, however, it possesses indirect anti-viral actions owing its anti-oxidation, anti-inflammation, immune improving properties. This study aims assess impacts of...