Tretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch investigate its physicochemical characteristics.Nanofibers were produced via electrospinning method surface topography was evaluated by Field Emission Scanning Electron Microscopy (FESEM). The functional groups polymer drug molecule possible interactions studied Fourier Transform Infrared Spectroscopy (FTIR). Drug...

Sulphasalazine (Sulf) is a class IV compound with low aqueous solubility and permeability which limit its therapeutic activity. This work aims to apply choline chloride (CC) hydroxide (CH) as hydrogen bond acceptor Sulf for the production of salt. New compounds were prepared characterized by XRD, DSC, FT-IR. Drug was evaluated in different media including pure water, buffer pH 1.2, 4.5, 6.8 evaluated. The diffractogram pattern Sulf-CH shows smooth low-intensity diffraction may indicate...

Topical administration of levothyroxine (T₄) helps to reduces deposits adipose tissue on skin. The question is whether topical application T₄ could lead systemic effects. In the present study a series nanofibrous membranes were electrospun into blends poly vinyl alcohol (PVA) and poly-N-isopropylacrylamide (PNIPAM) develop sustained delivery T₄. polymeric nanofiber mats characterized by field emission scanning electron microscopy (FESEM) fourier transform infrared (FTIR) spectroscopy. vitro...

The use of heat shock protein 90 inhibitors like 17-allylamino-17-demethoxy-geldanamycin (17-AAG) has been recently introduced as an attractive anticancer therapy. It shown that 17-AAG may potentiate the inhibitory effects some classical anticolorectal cancer (CRC) agents. In this study, two panels colorectal carcinoma cell lines were used to evaluate in combination with capecitabine and oxaliplatin double triple therapies on proliferation CRC lines. HT-29 all HCT-116 seeded culture media...

This work evaluated the potential usefulness of pharmacological activation cardiac ATP-sensitive potassium channels (K(ATP)) in prevention drug-induced QT prolongation anaesthetised guinea-pigs. Prolongation repolarisation and interval is an adverse effect many drugs blocking HERG channels. alteration can be dangerously arrhythmogenic has been associated with development a particular form ventricular tachyarrhythmia known as torsade de pointes.The well-known K(ATP) openers aprikalim,...

Fatty liver disease is commonly associated with inflammation, oxidative stress and apoptosis of hepatocytes. This study was designed to investigate the combinational therapeutic effects curcumin (CMN) Ursodeoxycholic acid (UDCA) on non-alcoholic fatty (NAFLD). Male Wistar rats were divided into 8 groups: NAFLD-induced rats, + CMN, UDCA, that received CMN UDCA. (200 mg/kg) UDCA (80 administered orally for 14 28 consecutive days. Biochemical histopathological analysis conducted in all groups....

Lipid suspensions as drug carriers, including conventional liposomes, ethosomes, transferosomes, proniosomes, niosomes, PEG-PPG-PEG niosomes and stratum corneum liposomes (cerosomes), were formulated compared.

The molecular structure of deferasirox (DFX) was fully optimized using a hybrid functional B3LYP and 6-311++G** basis set algorithm in Gaussian 09 software. A polarizable continuum model (PCM) employed as density theory (DFT) method to investigate the solvent effect on DFX solubility seven different binary mixtures. United Atom for Hartee–Fock (UAHF) radii were used drug various mass fractions free energies solvation (ΔGsol) kJ/mol, total electrostatic energy (kJ/mol), dipole moment (μ)...

This paper introduces a new delivery system for rapid and controlled drug release. Mixture of hydrophilic, (poly vinyl alcohol, PVA, randomly methylated beta-cyclodextrin, RM beta-CD), hydrophobic D,L-lactide, PLA, poly D,L-lactide-co-glycoside, PLGA) polymers were electrospun to make multi-layered/multicomponent nanofiber mat. The release characteristics the modified using layer by approach help compensate limitation individual materials. Incorporation beta-CD PVA solution was able...

Applicability of a solution model, i.e. Jouyban–Acree model (JAM), for calculating surface tension binary and ternary solvents at various temperatures has been shown employing experimental data collected from the literature. The accuracy was evaluated by average percentage deviation (APD) between calculated observed values. obtained overall APD (±S.D.) JAM using solvent were 4.06 (±4.27) 8.07 (±9.78)%, respectively correlative predictive analyses. corresponding values best similar literature...

Proniosomal formulations with non-ionic surfactant were studied. The effect of hydrophilicity and hydrophobicity one or two surfactants on drug solubility, proniosome surface structure stability skin permeation haloperidol from different investigated. Haloperidol (HP) was entrapped in proniosomes very high efficiency for all formulations. Stability studies performed at 4 degrees C 25 a period 6 weeks did not reveal any significant leakage (p>0.05). Formulations single found to increase the...

Aim: The aim of this work is to formulate a wound dressing for the delivery ascorbic acid and caffeine. Method: A was developed from electrospun nanofiber containing In vitro drug release performed at 25°C 32°C. Wound healing activity mats tested in vivo using rat model with skin excision. Antifungal on Candida albicans disc diffusion method. Results & conclusion: Zone inhibition 6.7 mm caffeine dressing; however, zone increased 16.7 samples both acid. Animals treated showed collagen...

Polymeric microparticles suitable for topical and transdermal delivery systems were studied using poly D,L lactide (PLA), co glycoside (PLGA), (N-isopropylacrylamide) (PNIPAM) ethyl cellulose (EC). Drug encapsulation efficacy, microparticle stability skin permeation studies of levothyroxine loaded carried out excised human skin, the pattern was observed confocal laser scanning microscopy. It found that had highest drug minimal leakage during 14 week storage period. The PNIPAM lowest...