A5041972769- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Respiratory viral infections research
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Pleural and Pulmonary Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Mycobacterium research and diagnosis
- HIV/AIDS Research and Interventions
- Inhalation and Respiratory Drug Delivery
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- HIV-related health complications and treatments
- Neuroscience of respiration and sleep
- Airway Management and Intubation Techniques
- Parvovirus B19 Infection Studies
- Bacterial biofilms and quorum sensing
- HIV Research and Treatment
- Ultrasound in Clinical Applications
University of Miami
2012-2023
Jackson Memorial Hospital
2013-2021
University of Miami Health System
2021
Pulmonary Associates
2020
Children’s Institute
2014
Harvard University Press
1990-2010
Boston Children's Hospital
1998-2009
Harvard University
1995-2009
State Key Laboratory of Respiratory Disease
2008
Beth Israel Deaconess Medical Center
2004
Abstract The clinical characteristics most relevant to the decision treat for a pulmonary exacerbation with antibiotics in cystic fibrosis patients were determined. Variables including age, increased cough frequency and sputum production, new crackles wheezing, asthma, symptomatic sinusitis, hemoptysis, decreased lung function, weight loss, acquisition of Pseudomonas aeruginosa collected large prospective multicenter database (Epidemiologic Study Cystic Fibrosis). During 12‐month baseline...
Chronic endobronchial bacterial infection evokes purulent airway secretions in patients with CF. The viscoelastic properties of these is primarily due to the presence polymerized DNA from degenerating leukocytes. Recombinant human DNase I (rhDNase) reduces viscosity CF sputum vitro. To test hypothesis that rhDNase would improve pulmonary function children and adults CF, we compared efficacy safety 10-day administration three doses aerosolized (0.6, 2.5, or 10.0 mg twice daily) 181...
Necrotising pneumonia (NP) is a severe complication of community-acquired characterised by liquefaction and cavitation lung tissue. The present study describes the epidemiology, aetiology, management outcomes children hospitalised with NP over 15-yr period. A retrospective observational cases was conducted from January 1990 to February 2005 analysing clinical presentation, laboratory data, hospital course long-term follow-up. total 80 were identified, number detected increasing 12, in period...
We present a case of patient with cystic fibrosis who was thought to be colonized Mycobacterium abscessus for 13 yr prior developing clinically apparent mycobacterial infection. However, histologic evidence indicated that invasive disease from the onset. While accepting chronic endobronchial colonization atypical mycobacteria may occur in patients fibrosis, repeated isolation sputum these should alert clinician possibility indolent disease. Early consideration treatment this infection any...
Congenital cystic adenomatoid malformation (CCAM), intralobar sequestration (ILS), extralobar (ELS), and lobar emphysema (LE) are well-accepted entities; however, certain findings common to all, particularly the parenchymal maldevelopment characterizing CCAM. Isolated reports have described bronchial atresia (BA) in some specimens all 4 entities, but this finding has not been evaluated a prospective manner. With aid of dissecting microscope, we prospectively examined 47 lung resected during...
Cystic fibrosis (CF) is a complex illness characterized by chronic lung infection leading to deterioration in function and respiratory failure over 85% of patients. An understanding the risk factors for that progression interaction these with current therapeutic strategies should materially improve prevention this progressive disease. The Epidemiologic Study Fibrosis (ESCF) was therefore designed as multicenter, longitudinal, observational study prospectively collect detailed clinical,...
The aim of this position paper is to define quality control and acceptance criteria for measuring passive respiratory mechanics in infants using the occlusion techniques ensure that valid results are obtained. These guidelines cover numerous aspects including: 1) terminology definitions; 2) equipment; 3) data acquisition; 4) handling analysis; 5) reporting results. Adherence these should measurement different lung function laboratories could be performed with an acceptable degree safety,...
The conducting of clinical trials in infants with cystic fibrosis (CF) has been hindered by lack sensitive outcome measures.To evaluate safety, feasibility, and ability to detect abnormalities lung function serial pulmonary tests (PFTs) CF.Multicenter observational study using a commercial device, rigorous training, ongoing quality control, over-reading data an independent panel. Raised volume rapid thoracoabdominal compression technique plethysmography were performed at enrollment 6 12...
Abstract Our objective was to study the effect of tobramycin solution for inhalation (TSI; TOBI®, Chiron Corp.) on lung function decline rate in 400 young persons with cystic fibrosis (CF) and mild disease. Effects hospitalization, antibiotic use, school days missed, nutritional status also were determined. This an open‐label, randomized (stratified by sex age group, i.e., 6–10 11–15 years), parallel‐group, multicenter study. Routine subject management (control group) compared routine plus...
As the shape, compliance, and deformability of rib cage (RC) change during infancy, RC participation in quiet breathing may increase. We used respiratory inductive plethysmography (RIP) to determine relative contributions abdomen (AB) tidal volume (Vt) 20 studies 14 healthy infants 1 26 months age natural sleep. RIP was calibrated with simultaneous flow measurements (anesthesia mask pneumotachograph) by least squares method statistical analysis. analyzed segments without measurement for...
In Brief Study Design. To assess the rate of decline in pulmonary function Duchenne muscular dystrophy (DMD) before and after posterior spinal fusion for scoliosis. Objective. compare respiratory using percent normal forced vital capacity (%FVC) measurements fusion. Summary Background Data. Posterior scoliosis is used widely DMD, although long-term effects have not been well established. Methods. Fifty-six patients were assessed. Percent was outcome parameter with data analysis a mixed-model...
Abstract Acute respiratory infections are amongst the leading causes of childhood morbidity and mortality globally. Viruses predominant cause such infections, but mixed etiologies with bacteria has for decades raised question interplay between them in causality determination outcome infections. In this review, we examine recent microbiological, biochemical, immunological advances that contribute to elucidating mechanisms by which specific viruses enable bacterial airway, exacerbate them. We...
Newborn infants, in contrast to adults, dynamically maintain end-expiratory lung volume (EEV) above relaxation volume. The purpose of this study was determine at what age children develop a breathing strategy that is relaxed, i.e., determined by the mechanical characteristics and chest wall. Forty studies were performed 27 healthy infants aged 1 mo 8 yr during natural sleep. Volume changes recorded with use respiratory inductance plethysmography (RIP). signal differentiated yield flow....
Chronic mucoid Pseudomonas aeruginosa within the airway in cystic fibrosis (CF) patients can determine prognosis. Understanding risk factors of P. acquisition may change how we deliver care. This study aims to evaluate whether presence reported predict disease severity including gender, CFTR genotype, bacterial organisms cultures, and serum levels vitamins A E, albumin, C-reactive protein, alpha 1-antitrypsin, immunoglobulins increased acquisition.Primary endpoint was age at first transition...