A5092181067- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Plant Physiology and Cultivation Studies
- Phytochemistry and Biological Activities
- Glycosylation and Glycoproteins Research
- Adenosine and Purinergic Signaling
- Botanical Research and Applications
- Medicinal Plants and Bioactive Compounds
- Biological and pharmacological studies of plants
- Horticultural and Viticultural Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Neuroprotection
- Alzheimer's disease research and treatments
- Multicomponent Synthesis of Heterocycles
- Monoclonal and Polyclonal Antibodies Research
Abdelmalek Essaâdi University
2023-2024
Alzheimer's disease (AD) is a chronic neurodegenerative condition characterized by progressive cognitive impairment. While the formation of β-amyloid plaques and neurofibrillary tangles are hallmarks features AD, downstream consequence these byproducts disruption cholinergic glutamatergic neural systems. Growing evidence for existence interplay between AChE NMDARs has opened up new venues discovery novel ligands endowed with anticholinesterase NMDAR-blocking activity. Plants belonging to...
Abstract The exact cause of Parkinson's disease is unknown, and there currently no cure for the disease. However, are several treatment options available to help manage its symptoms. prevalence PD has been increasing globally, including in Morocco. This study investigated potential Aloysia citriodora , also known as lemon verbena, treating Lemon verbena a plant commonly used Morocco central nervous system related diseases. It traditionally relaxant sedative, antioxidant antimicrobial...
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in midbrain. Current treatments provide limited symptomatic relief without halting progression. A multi-targeting approach has shown potential benefits treating diseases. In this study, we employed
GPCRs are a family of transmembrane receptors that profoundly linked to various neurological disorders, among which is Parkinson's disease (PD). PD the second most ubiquitous disorder after Alzheimer's disease, characterized by depletion dopamine in central nervous system due impairment dopaminergic neurons, leading involuntary movements or dyskinesia. The current standard care for Levodopa, precursor, yet chronic use this agent can exacerbate motor symptoms. Recent studies have investigated...
Dendrobium nobile Lindl alkaloids, or DNLA for short, are the most active ingredients found in D.nobile, a top grade plant Shen Nong Ben Cao Jing, with an extensive history of medicinal use Chinese traditional medicine (TCM) as multifunctional therapeutic agent. Recent evidence has emerged linking neuroprotective and anti-aging effects to their involvement promoting autophagy toxic amyloid-β (Aβ) plaques modulation key enzymes involved hyperphosphorylation Tau proteins. Although amyloid...