A5025326324- Histone Deacetylase Inhibitors Research
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Sarcoma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Protein Degradation and Inhibitors
Second Affiliated Hospital of Soochow University
2021-2022
Soochow University
2021-2022
HBO1 (KAT7 or MYST2) is a histone acetyltransferase that acetylates H3 and H4 histones. Methods: expression was tested in human OS tissues cells. Genetic strategies, including shRNA, CRISPR/Cas9 overexpression constructs, were applied to exogenously alter The inhibitor WM-3835 utilized block activation. Results:HBO1 mRNA protein significantly elevated In established (MG63/U2OS lines) primary cells, shRNA-mediated silencing CRISPR/Cas9-induced knockout able potently inhibit cell viability,...
Abstract We here showed that ADCK1 (AarF domain-containing kinase 1), a mitochondrial protein, is upregulated in human osteosarcoma (OS) tissues and OS cells. In primary established cells, shRNA or CRISPR/Cas9-induced knockout (KO) remarkably inhibited cell viability, proliferation migration, provoked apoptosis activation. Conversely, ectopic overexpression exerted pro-cancerous activity by promoting migration. depletion disrupted functions cells induced membrane potential reduction, ATP...
Objective To evaluate the midterm outcomes and capsular healing in patients who had interportal capsulotomy versus periportal of hip arthroscopy. Methods Retrospectively reviewed 33 with labral tear received arthroscopy, an average age 41 (27‐67) years, including 13 cases Cam deformity three Pincer deformity. All positive sign flexion adduction internal rotation or abduction external rotation. With MRI radiographic (CT, X plain) imageological examination. showed that all tear. Radiographic...