A5078615765- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Synthesis and Catalytic Reactions
- Synthesis of β-Lactam Compounds
- DNA and Nucleic Acid Chemistry
- bioluminescence and chemiluminescence research
- Mass Spectrometry Techniques and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
- Synthetic Organic Chemistry Methods
- Molecular Sensors and Ion Detection
- Synthesis of Organic Compounds
- Cancer therapeutics and mechanisms
- Luminescence and Fluorescent Materials
- Carbohydrate Chemistry and Synthesis
- Viral Infections and Immunology Research
- Biotin and Related Studies
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Asymmetric Hydrogenation and Catalysis
- Fluorine in Organic Chemistry
- Fungal Plant Pathogen Control
- Dendrimers and Hyperbranched Polymers
- Synthesis of heterocyclic compounds
Abbott Fund
2000-2010
Abbott (United Kingdom)
1995
University of Notre Dame
1983
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-lactams from substituted hydroxamic acidsMarvin J. Miller, Phillip G. Mattingly, Marjorie A. Morrison, and James F. Kerwin Jr.Cite this: Am. Chem. Soc. 1980, 102, 23, 7026–7032Publication Date (Print):November 5, 1980Publication History Published online1 May 2002Published inissue 5 November 1980https://pubs.acs.org/doi/10.1021/ja00543a021https://doi.org/10.1021/ja00543a021research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTitanium trichloride reduction of substituted N-hydroxy-2-azetidinones and other hydroxamic acidsPhillip G. Mattingly Marvin J. MillerCite this: Org. Chem. 1980, 45, 3, 410–415Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/jo01291a007https://doi.org/10.1021/jo01291a007research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective syntheses of 3-substituted 4-(alkoxycarbonyl)-2-azetidinones from malic acidMarvin J. Miller, Joginder S. Bajwa, Phillip G. Mattingly, and Kathleen PetersonCite this: Org. Chem. 1982, 47, 25, 4928–4933Publication Date (Print):December 1, 1982Publication History Published online1 May 2002Published inissue 1 December 1982https://pubs.acs.org/doi/10.1021/jo00146a020https://doi.org/10.1021/jo00146a020research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of 2-azetidinones from serinehydroxamates: approaches to the synthesis 3-aminonocardicinic acidPhillip G. Mattingly and Marvin J. MillerCite this: Org. Chem. 1981, 46, 8, 1557–1564Publication Date (Print):April 1, 1981Publication History Published online1 May 2002Published inissue 1 April 1981https://pubs.acs.org/doi/10.1021/jo00321a007https://doi.org/10.1021/jo00321a007research-articleACS PublicationsRequest reuse permissionsArticle...
We identified IgG reactive with human cardiac troponin-I (cTnI) in plasma and serum samples (N = 1930) from normal blood donors, sample cohorts characterized on the basis of clinical biomarkers associated cardiac, infectious, autoimmune diseases. cTnI brain natriuretic peptide were chosen to reflect myocyte damage or left ventricular dysfunction, respectively. The infectious disease serologically positive for antibodies hepatitis B (natural infection), C virus, Chagas (i.e., T.cruzi)....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA facile synthesis of substituted N-hydroxy-2-azetidinones. A biogenetic type .beta.-lactam synthesisPhillip G. Mattingly, James F. Kerwin Jr., and Marvin J. MillerCite this: Am. Chem. Soc. 1979, 101, 14, 3983–3985Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00508a056https://doi.org/10.1021/ja00508a056research-articleACS PublicationsRequest reuse...
N α-tert-Butoxycarbonyl α,ω-alkanediamine hydrochlorides 3a-e are prepared from the amino alcohos in yields of 66-87%. Reaction free amine with di-tert-butyl dicarbonate gives N-tert-Butoxycarbonylamino alcohol 1a-e. One-pot conversion to azide 2a-e via mesylate under phase-transfer conditions followed by hydrogenolysis presence chloroform title compounds.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTNeopentyl 3-Triflyloxypropanesulfonate. A Reactive Sulfopropylation Reagent for the Preparation of Chemiluminescent LabelsMaciej Adamczyk, Yon-Yih Chen, Phillip G. Mattingly, You Pan, and Sushil RegeView Author Information Abbott Laboratories, Diagnostics Division, Division Organic Chemistry (9-NM), Building AP 20, 100 Park Road, Park, Illinois 60064 Cite this: J. Org. Chem. 1998, 63, 16, 5636–5639Publication Date (Web):July 7, 1998Publication History...
Surface plasmon resonance (SPR) analysis was used to assess the immunoreactivity of anti-biotin (4) and anti-fluorescein (5) monoclonal antibody after conjugation with N-hydroxysuccinimide ester acridinium-9-carboxamide 1. Only minor changes in apparent equilibrium dissociation constants conjugates for their ligands resulted from process. However, comparison initial binding rate those unmodified antibodies over a range concentrations showed that were partially inactivated. The retained at...
Fifteen hapten-bovine serum albumin (BSA) conjugates were prepared from five commercially available activated haptens. Each hapten was coupled to BSA at three different ratios. The characterized by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and two mass spectrometry (MS) methods: matrix-assisted laser desorption ionization (MALDI) liquid chromatography-electrospray (LC-ESI). SDS-PAGE useful in detecting protein cross-linking, but not assessing density. MALDI-MS...
Abstract 10‐Methyl‐acridinium‐9‐( N ‐sulphonylcarboxamide) salts are prepared via acylation of sulphonamides with acridine‐9‐carboxylic acid chloride and subsequent ‐alkylation methyl triflate. Substituents on the sulphonamide component were varied to show effect steric electronic factors kinetics light output. The lifetime chemiluminescence output ranged from 1 50 seconds for 15 compounds reported. long‐term stability new was superior phenyl ester counterparts.
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of 5- and 6-Hydroxymethylfluorescein PhosphoramiditesMaciej Adamczyk, Clifford M. Chan, James R. Fino, Phillip G. MattinglyView Author Information Department Chemistry (09NM), Abbott Laboratories, Diagnostics Division, Building AP 20, 100 Park Road, Park, Illinois 60064-6016 Cite this: J. Org. Chem. 2000, 65, 2, 596–601Publication Date (Web):December 21, 1999Publication History Received14 September 1999Published online21 December inissue 1...
(2001). SYNTHESIS OF COELENTERAZINE. Organic Preparations and Procedures International: Vol. 33, No. 5, pp. 477-485.
A library of 16 thyroxine analog biosensors were prepared for use on the BIAcore surface plasmon resonance instrument. An anti-thyroxine monoclonal antibody and its Fab fragment tested with each biosensor to generate association dissociation rate constants, equilibrium Gibbs free energy values characterizing binding event.
A library of thyroxine analogs and tracers was prepared, their solution binding affinities for an anti-T4 Fab fragment were determined using a single high-density L-T4 biosensor surface in BIAcore plasmon resonance instrument. The analog calibrated by determination the initial rate known concentrations free to surface. range individual tracer subsequently mixed with fixed concentration fragment. each at equilibrium determined, dissociation constant (KD) case derived. KD values are compared...
5(6)-Carboxyfluorescein is protected as the diacetate then reduced to 5(6)-(hydroxymethyl)fluorescein diacetate. The separated isomers are subjected a Mitsunobu reaction with dibenzyl imidodicarbonate, yielding diprotected 5- and 6-(aminomethyl)fluorescein Methanolysis of acetates followed by deprotection HBr/acetic acid gives hydrobromide.