A5101569205- Heavy Metal Exposure and Toxicity
- Data Management and Algorithms
- Trace Elements in Health
- Human Mobility and Location-Based Analysis
- Heavy metals in environment
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Data Stream Mining Techniques
- Chromium effects and bioremediation
- Gene expression and cancer classification
- Data Visualization and Analytics
- Bioinformatics and Genomic Networks
- Machine Learning and Algorithms
- Advanced Database Systems and Queries
- Geographic Information Systems Studies
- Mobile Crowdsensing and Crowdsourcing
- Recommender Systems and Techniques
- Medical and Biological Ozone Research
- Parallel Computing and Optimization Techniques
- Global Health Care Issues
- Distributed systems and fault tolerance
- Image and Video Quality Assessment
- Indoor and Outdoor Localization Technologies
- Green IT and Sustainability
- Semantic Web and Ontologies
Northeast Agricultural University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Huazhong Agricultural University
2023-2024
Xiamen University
2024
Wuhan College
2023
University of Pittsburgh
2015-2021
Shenyang University of Chemical Technology
2011-2015
China Pharmaceutical University
2010
After heavy metals enter the body, they affect a variety of organs, particularly main metabolic organ, liver. Moreover, people are more likely to be exposed multiple than single metal. We explored associations between exposure metal mixture and liver function biomarkers.This study involved 1171 residents living in areas with or without northeast China. Urine concentrations chromium (Cr), cadmium (Cd), lead (Pb), manganese (Mn) were measured. Total protein (TP), albumin (ALB), aspartate...
Dyslipidemia is a common disease in the older population and represents considerable burden worldwide. Epidemiological experimental studies have indicated associations between heavy metal exposure dyslipidemia; few investigated effects of mixture interactions metals on dyslipidemia. We recruited 1121 participants living metal-contaminated control areas northeast China from cross-sectional survey (2017-2019). Urinary including chromium (Cr), cadmium (Cd), lead (Pb), manganese (Mn)...
Biosynthesis, stabilization, and storage of carotenoids are vital processes in plants that collectively contribute to the vibrant colors observed flowers fruits. Despite its importance, carotenoid pathway remains poorly understood lacks thorough characterization. We identified two homologous genes, BjA02.PC1 BjB04.PC2, belonging esterase/lipase/thioesterase (ELT) family acyltransferases. showed BjPCs association with fibrillin gene BjFBN1b control stable yellow Brassica juncea. Through...
The impact of heavy metals on liver function has been examined in numerous epidemiological studies. However, these findings lack consistency and longitudinal validation.
Environmental hexavalent chromium contamination in northeast China has been ongoing for over 60 years and health outcomes related with (Cr) pollution were observed polluted arears, but exposure pathways remains unclear. This study aims to evaluate the association between Cr dose through multiple concentration urine, identify most contributed pathway. We used risk assessment tools individual parameters estimate eight doses (CD) three routes (inhalation, ingestion, dermal contact) four...
We aimed to investigate whether urinary metal mixtures are associated with the homeostasis of inflammatory mediators in middle-aged and older adults. A four-visit repeated-measures study was conducted 98 adults from five communities Beijing, China. Only one person lost follow-up at third visit. Ultimately, 391 observations were included analysis. The concentrations 10 metals measured each visit using inductively coupled plasma mass spectrometry (ICP-MS) a limit detection (LOD) ranging 0.002...
Plant cytoplasmic male sterility is caused by mutations and rearrangements of mitochondrial genes. It serves as a significant way to utilize hybrid vigor enhance crop yield. Ogu CMS natural type discovered in radishes, being successfully transferred rapeseed cruciferous vegetables. However, current studies lack depth exploring the molecular mechanisms its sterility. In this study, we confirmed orf138 causal gene for through genetic transformation Arabidopsis. Transcriptome analysis aborted...
The exponential growth of high dimensional biological data has led to a rapid increase in demand for automated approaches knowledge production. Existing methods rely on two general address this challenge: 1) the Theorydriven approach, which utilizes prior accumulated knowledge, and 2)the Data-driven solely deduce scientific knowledge. Both these alone suffer from bias toward past/present as they fail incorporate all current that is available make new discoveries. In paper, we show how an...
Background and Aims Previous studies have focused only on the cardiometabolic effects of selenium concentrations. We explored whether levels their visit-to-visit variability (VVV) individual mean (IM) are independently associated with risk factors. Methods A three-wave repeated-measures study older adults high ( n = 201) was conducted in Beijing from 2016 to 2018. Whole blood urinary concentrations were measured. VVV IM used profile homeostasis biomarkers. Four indicators, namely standard...
Researchers have reported that chromium (Cr) exposure may be associated with metabolism of glucose and lipids in residents living a long-term Cr polluted area. Previous statistical analysis is mainly focused on individual exposure. Furtherly, we aim to investigated the independent, combined, interaction effects co-exposure urine (UCr) cadmium (UCd), lead (UPb) manganese (UMn) body mass index (BMI), waist circumference, risk overweight abdominal obesity.We enrolled 1187 participants from...
Exploration over large datasets is a key first step in data analysis, as users may be unfamiliar with the underlying database schema and unable to construct precise queries that represent their interests. Such exploration task usually involves executing numerous ad-hoc queries, which requires considerable amount of time human effort. In this paper, we present REQUEST, novel framework designed minimize effort enable both effective efficient exploration. REQUEST supports query-from-examples...
There is mounting evidence that manufacturing energy and environmental costs are a growing factor in the overall footprint of computing systems. The quantification these impacts requires evaluation both use phase energy/environmental major integrated circuit (IC) components, including processing units, memory, storage. In particular, expansions memory cache can potentially increase beyond what be recovered through advantages for reasonable usage patterns. With this holistic view...
Abstract High-throughput sequencing and the availability of large online data repositories (e.g. The Cancer Genome Atlas Trans-Omics for Precision Medicine) have potential to revolutionize systems biology by enabling researchers study interactions between from different modalities (i.e. genetic, genomic, clinical, behavioral, etc.). Currently, mining statistical approaches are confined identifying correlates in these datasets, but often interested cause-and-effect relationships. Causal...
The proliferation of mobile, ubiquitous and spatial computing has led to a number services aiming into facilitate the exploration city. Platforms such as Foursquare Yelp curate information about establishments in an area that can then be used for recommendation purposes. Traditionally approach followed by these systems is rank places based on their popularity, proximity or any other feature represents quality venue return top-k them. However, this approach, while simple intuitive, not...
Recently, navigation and localization systems have emerged to support queries like the shortest distance in either indoor or outdoor with additional constraints. These systems, however, neither combine information nor consider external natural conditions weather that one may face across an path. In this demonstration paper we present CAPRIO , which proposes implements a novel graph representation integrates discover paths personalize exposure while minimizes overall path length. We also...