A5066623102- Bacterial Infections and Vaccines
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Cell Adhesion Molecules Research
- Child and Adolescent Health
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Global Maternal and Child Health
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Blood disorders and treatments
- Tracheal and airway disorders
- Protease and Inhibitor Mechanisms
- Asthma and respiratory diseases
- Infant Nutrition and Health
- Pediatric health and respiratory diseases
- Global Health Workforce Issues
- Innovations in Medical Education
- Congenital Diaphragmatic Hernia Studies
- Food Allergy and Anaphylaxis Research
Flinders University
2014-2025
Flinders Medical Centre
2003-2019
Helios Klinikum Krefeld
2015
Royal Australasian College of Physicians
2007-2009
University of South Australia
1999
Princess Margaret Hospital for Children
1990-1993
University of London
1989-1990
Universidad de Londres
1989
Women's and Children's Hospital
1984
Starship Children's Health
1984
Existing clinical case definitions of pertussis are decades old and based largely on presentation in infants children, yet an increasing burden is borne by adolescents adults who may manifest distinct signs/symptoms. Therefore, a "one-size-fits-all" definition no longer appropriate. Seeking to improve diagnosis, the Global Pertussis Initiative (GPI) developed algorithm that delineates signs/symptoms most common 3 age groups: 0–3 months, 4 months 9 years, ≥10 years. These alone, but do...
The Global Pertussis Initiative, an expert scientific forum, was established to address the ongoing problems associated with pertussis disease worldwide.The group analyzed trends, developed recommendations improve control through expanded vaccination strategies, and proposed solutions barriers implementation support of research activities.Bordetella infection is endemic continues be a serious problem among unvaccinated or incompletely vaccinated infants. In addition, reported incidence...
Objectives : To enumerate the cellular composition of airways in infants with acute bronchiolitis. Methodology Cells were obtained by airway lavage from upper and lower peripheral blood respiratory syncytial virus (RSV)+ bronchiolitis, RSV– bronchiolitis age‐matched controls. Results Neutrophils are predominant cells present airway. at a higher number/unit volume than blood. Conclusions Neutrophils, being dominant infiltrate into airway, likely to contribute pathophysiology Therapies...
The mechanisms by which respiratory syncytial virus (RSV) infection induces bronchiolitis and airway disease are unclear. presence of large numbers polymorphonuclear leukocytes (PMN) in the airways infants with RSV suggests a potential role PMN injury associated infection. To investigate neutrophils bronchiolitis, human alveolar type II cells (A549 cells) were infected different doses for 6-48 h. A 51Cr-releasing assay was used to measure PMN-induced damage image analysis determine adhesion...
The incidence of the sudden infant death syndrome parallels that respiratory tract infections in paediatric community. On basis aetiology may lie an unusual response to a trivial intercurrent infection necropsy study was carried out investigating pulmonary immunoglobulins 16 victims and series infants (controls) who had died non-pulmonary causes. Compared with controls grossly raised concentrations IgG, IgM, less extent IgA lung lavage samples. In addition, interstitial terminal airway cells...
Although epidemiological evidence is generally supportive of a causal association between respiratory syncytial virus (RSV) bronchiolitis during infancy and the development persistent wheeze/asthma, if not allergy, mechanism by which this occurs an explanation for why all children do succumb remains to be elucidated. Breast feeding has been found confer protective effect against infections such as RSV allergy; however, again there little direct no clear mechanism. In study, we examined...
Summary Background Current peanut oral immunotherapy is hampered by frequent adverse events. It has been shown that boiling can reduce allergenicity. Hypoallergenic products have the potential to treatment‐related reactions during desensitization. Objective To show extended (for up 12 h) progressively allergenicity while retaining T cell reactivity. Methods Raw peanuts were boiled for half, 1, 2, 4 and h in deionized water. After dehydration, raw ground, defatted soluble proteins extracted...
Objective Our primary objective was to examine the global paediatric workforce and better understand geographic differences in number of paediatricians globally. Secondary objectives were describe expectations, who provides children with preventative care when transition out care. Design Survey identified leaders each country. Setting Paediatric association worldwide. Main outcome measures Paediatrician numbers, provision for children, age adult Results Responses obtained from 121 countries...
Bronchiolitis is characterized histologically by epithelial necrosis and peribronchial infiltration of leukocytes, with a high percentage neutrophils in the airways. We investigated expression adhesion molecules (CD11a, CD11b, CD18, CD31, CD54, CD62L) on from nasopharyngeal aspirates (NPAs) peripheral blood (PB) infants respiratory syncytial virus (RSV)-induced bronchiolitis. The CD31 CD62L NPAs decreased CD54 increased compared cells PB RSV-infected infants. CD18 also control Shedding RSV...
Respiratory epithelium is both a target and an effector of airway inflammation. Adhesion molecules on play important role in variety diseases. syncytial virus (RSV) the most pathogen for diseases infants. The expression adhesion RSV infection, however, unclear. selected major histocompatibility complex (MHC) class I II antigens human alveolar type epithelial cell line (A549) infected with was investigated by means flow cytometry immunocytochemistry. results showed that intercellular...