A5048780434- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- HER2/EGFR in Cancer Research
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Orthopedic Surgery and Rehabilitation
- Sarcoidosis and Beryllium Toxicity Research
- Diabetes and associated disorders
- Vasculitis and related conditions
- Bone health and treatments
- Bone and Joint Diseases
- Hepatitis Viruses Studies and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Growth Hormone and Insulin-like Growth Factors
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Fungal Infections and Studies
Tehran University of Medical Sciences
2018-2025
Mazandaran University of Medical Sciences
2014-2023
Imam Khomeini Hospital
2010-2022
University of Tehran
2021
Rasool Akram Hospital
2006
Iran University of Medical Sciences
2006
Our previous microscopic observations on the wet mount of cultured Candida yeast showed release large extracellular vesicles (EVs) that contained intracellular bacteria (∼500-5000 nm). We used tropicalis, to examine internalization nanoparticles (NPs) with different properties find out whether size and flexibility both EVs cell wall pores play role in transport particles across wall. tropicalis was N-acetylglucoseamine-yeast extract broth (NYB) examined for every 12 h by light microscope....
Musculoskeletal disorders are prevalent and expensive diseases. This study was conducted to estimate compare the costs of illness three musculoskeletal conditions. Patients with rheumatoid arthritis (RA), knee osteoarthritis (OA), fibromyalgia syndrome (FMS) who referred a rheumatologist completed questionnaires about their socio-demographic condition, clinical status, disease (direct included visits, laboratory tests, imaging, medications; indirect absence from paid work, functional...
This study aimed to investigate psychiatric disorders in Iranian female patients with fibromyalgia (FM).Female patients, newly diagnosed FM, were interviewed by a psychiatrist for assessments during 2-year period.The diagnosis of the was based on Diagnostic and Statistical Manual Mental Disorders, Fifth Edition (DSM-5), sleep quality evaluated using Pittsburgh Sleep Quality Index (PSQI).In total, 159 mean age 42.15 ± 9.89 recruited this study. Over 92% cases also at least one type disorder....
Overexpression of HER2 has been reported in many types cancer, making it a perfect candidate for targeted immunotherapy. The combination two FDA approved monoclonal antibodies (mAbs), trastuzumab and pertuzumab, more robust anti-tumor activity patients with HER2-overexpressing breast cancer. We recently produced new humanized anti-HER2 mAb, hersintuzumab, which recognizes different epitope than pertuzumab on HER2. This trastuzumab, exhibits potent each parental mAb alone. Here we have...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of outbreak led to disease 2019 (COVID-19) pandemic. Receptor binding domain (RBD) spike (S) protein SARS-CoV-2 considered as a major target for immunotherapy and vaccine design. Here, we generated characterized panel anti-RBD monoclonal antibodies (MAbs) isolated from eukaryotic recombinant RBD-immunized mice by hybridoma technology. Epitope mapping was performed using 20-mer overlapping peptides spanning...
↑What is "already known" in this topic: High prevalence of periodontal disease was reported patients with rheumatoid arthritis and it may be RA activity/ severity associated diseases.Control infection gingival inflammation could reduce the or activity RA. →What article adds:About two thirds were found periodontitis unrelated to (p=0.22).Because remarkable frequency, periodic examination periodental status seems necessary.
Abstract Aim Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular involvement. Metabolic syndrome (MetS) includes a group classic factors probably proinflammatory conditions. The aim the present study was to evaluate frequency MetS in SLE patients. Methods Demographic, clinical and laboratory features 73 patients were compared age–sex matched controls using Disease Activity Index (SLEDAI), Lupus Damage (SDI) Health Assessment Questionnaire (HAQ)....
Background:: Osteoarthritis (OA) is the most common joint disorder without any curative treatment so, pharmacologic and nonpharmacologic modalities are used to improve pain disability. Objectives:: This a study for evaluation of efficacy safety Elaeagnus angustifolia ginger extracts in patients with osteoarthritis knee. Patients Methods:: randomized double-blind clinical trial carried out on 80 outpatients knee OA. The were take 200 mg extract E. or placebo. Knee radiography, serum...
Objective: Homo- and heterodimerization of the receptor tyrosine kinase HER2 hyperactivate several downstream signaling pathways, leading to uncontrolled growth proliferation tumor cells. Anti-HER2 monoclonal antibodies (mAbs) may induce different effects on dimerization signaling. Methods: The effect two inhibitory (2A8, 1T0) one stimulatory (1H9) anti-HER2 mAbs either alone or in combination with trastuzumab was investigated AKT ERK pathways degradation a human breast cancer cell line...
Context: Multiple sclerosis (MS) is an autoimmune and chronic inflammatory disease of CNS. The α-L-guluronic acid (G2013) as novel NSAID with immunomodulatory effects has shown its positive in various investigations.Objective: Present research aimed to study the potency G2013 on gene expression TLR2, TLR4, MyD88, TNF-α CD52 PBMCs MS patients under vitro conditions. Materials methods: 24 blood samples from healthy controls were considered for RT-PCR flow cytometry techniques two different...
Failure of current therapies to cure chronic hepatitis B has led renewed interest in that stimulate the host immune system. APOBEC3 (A3) family enzymes have been shown induce mutations virus (HBV) covalently closed circular DNA (cccDNA) leading inhibition HBV transcription and replication. Pattern recognition receptor (PRR) agonists reported suppress HBV, but it is unclear whether these A3 gene expression hepatocytes. We, therefore, evaluated PRR signaling activates genes other innate...
Background: Fibromyalgia syndrome (FMS) is a chronic musculoskeletal condition, which can reduce the quality of life (QoL). Objectives: This study aimed to evaluate impact FMS on health-related (HRQoL) and possible related factors such as sociodemographic psychological variables. Methods: In this cross-sectional study, 150 women patients with were included who visited psychosomatic clinic at referral center in northern Iran. The samples selected consecutive procedure from April 2019 March...