A5002103084- Folate and B Vitamins Research
- Neuropeptides and Animal Physiology
- Arsenic contamination and mitigation
- PARP inhibition in cancer therapy
- Phytochemical and Pharmacological Studies
- FOXO transcription factor regulation
- Epilepsy research and treatment
- Peptidase Inhibition and Analysis
- Marine Sponges and Natural Products
- Signaling Pathways in Disease
- Heavy Metal Exposure and Toxicity
- Gastric Cancer Management and Outcomes
- Angiogenesis and VEGF in Cancer
- Mangiferin and Mango Extracts
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory mediators and NSAID effects
- Hops Chemistry and Applications
- Cancer, Lipids, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Electrochemical Analysis and Applications
- Pharmacological Effects and Toxicity Studies
Second Hospital of Shandong University
2010-2023
Abstract: For targeted gastric carcinoma therapy, hyaluronic acid (HA)-modified layer-by-layer nanoparticles (NPs) are applied for improving anticancer treatment efficacy and reducing toxicity side effects. The aim of this study was to develop HA-modified NPs the co-loading irinotecan (IRN) 5-fluorouracil (5-FU). A novel polymer–chitosan (CH)–HA hybrid formulation (HA–CH–IRN/5-FU NPs) consisting poly(D,L-lactide- co -glycolide) (PLGA) IRN as core, CH 5-FU a shell on core HA outmost layer...
Abstract Colorectal cancer (CRC) is a major health problem and third most common deaths in western world. Dietary interventions together with modified dietary style can prevent the CRC humans. Xanthohumol (XHA), polyphenol isolated from Humulus lupulus L. contains many beneficial effects. The aim of study to analyze effect XHA on Azoxymethane (AOM)‐induced experimental rats. Levels MDA were increased enzymic antioxidants levels decreased AOM‐induced However, these reversed upon treatment....
Abstract Background Globally, colon cancer (CC) is the third reason of tumor‐related deaths. Previous reports indicate that Forkhead box O3 (FOXO3) involved in development various tumors and may have different effects depending upon types tumors. Hence, this study was to examine FOXO3 on CC cells uncover possible mechanisms. Methods MTT cell count assay were applied analyze viability transfected cells. rVista, dual luciferase reporter assay, chromatin immunoprecipitation used identify...
Purpose: To evaluate the effect of dezocine on postoperative ratio Th1/Th2 cytokines in patients undergoing laparoscopic radical gastrectomy. Patients and Methods: Sixty gastrectomy were randomly divided into two groups (n=30): group (Group D) sufentanil S). They received patient-controlled intravenous analgesia (PCIA) after operation with either 0.8 mg/kg or 2 μg/kg Both also ondansetron 8 mg diluted to 100 mL saline. The primary outcome was at predetermined intervals, 30 min before...
BACKGROUND:In developed countries, colon cancer is a leading cause of cancer-associated mortality. Dietary changes have resulted in an increased incidence Asia. This study aimed to investigate the effects structural analog endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH₂) on human cells vitro. MATERIAL AND METHODS:Human DLD-1 and RKO CCD-18Co normal colonic fibroblasts were treated with increasing doses endomorphin-2. Cells underwent MTT assay, fluorescence confocal flow cytometry, Hoechst 33258...