A5040090829- Inflammatory Bowel Disease
- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Microscopic Colitis
- Pharmaceutical studies and practices
- Immune cells in cancer
- Tracheal and airway disorders
- Immune responses and vaccinations
- Cancer Immunotherapy and Biomarkers
- Asthma and respiratory diseases
- Mast cells and histamine
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders
- T-cell and B-cell Immunology
- Esophageal and GI Pathology
- Eosinophilic Disorders and Syndromes
- Adolescent and Pediatric Healthcare
- Mobile Health and mHealth Applications
- Congenital Diaphragmatic Hernia Studies
- Allergic Rhinitis and Sensitization
- Esophageal Cancer Research and Treatment
- IgG4-Related and Inflammatory Diseases
- Vasculitis and related conditions
- Multiple Sclerosis Research Studies
Centre Hospitalier de l’Université de Montréal
2014-2025
Centre Hospitalier Universitaire Sainte-Justine
2012-2025
Université de Montréal
2015-2025
McGill University Health Centre
2022-2023
Montreal Children's Hospital
2022-2023
McGill University
2022
The drug targets IL23 and IL12 regulate pathogenicity plasticity of intestinal Th17 cells in Crohn's disease (CD) ulcerative colitis (UC), the two most common inflammatory bowel diseases (IBD). However, studies examining dysregulation mesenteric lymph nodes (mLNs) these patients are rare. We showed that mLNs, CD could be distinguished from UC by increased frequencies CCR6+CXCR3-ROR+Tbet-CD4+ (Th17) memory T enriched CD62Llow effector (TEM), their differentially expressed molecular profile....
Abstract Background Patient-reported outcome measures (PROMs) are essential for managing chronic diseases, as they provide valuable insights into patients’ perspectives on their condition’s impact and help tailor treatments accordingly. However, collecting this information from pediatric patients with inflammatory bowel disease (IBD) presents several challenges, such the reluctance of to discuss sensitive topics movements, defecation, rectal bleeding. Additionally, subjective nature...
Abstract Background and Aims Innate immune cells, including dendritic cells (DCs), monocytes (Mono), macrophages (Mac), natural killer (NK), innate lymphoid (ILC), contribute to chronic inflammation in tissues. Here, we characterized the cell landscape inflamed mesenteric lymph nodes (MLNs) of patients with inflammatory bowel diseases (IBD) at single-cell level. Methods Surgically resected colonic MLNs were obtained from Crohn’s disease (CD; n = 3), ulcerative colitis (UC; non-inflamed UC (n...
The aim of the present study was to evaluate efficacy and short-term safety topical mitomycin-C, an antifibrotic agent, in preventing recurrence anastomotic strictures after surgical repair esophageal atresia (EA).We retrospectively reviewed medical records patients with recurrent EA surgery who underwent at least 3 dilations. We compared outcome (ie, resolution stricture) group that received mitomycin-C treatment endoscopic dilation a historical cohort treated by dilations alone.A total 11...
Summary Neutrophils are detected in inflamed colon Crohn’s disease (CD). However, whether the frequency and/or activation of circulating or gut tissue neutrophils correlate with endoscopic severity remains to be investigated. A cohort 73 CD patients was prospectively enrolled according and treatment history. Individuals active were stratified using Montreal classification. Harvey–Bradshaw Index (HBI) Simple Endoscopic Score for Disease (SES-CD) performed at time ileocolonoscopy. Frequency...
Abstract Background and Aims CD14+ mononuclear phagocytes [MNPs] T cells infiltrate colon in ulcerative colitis [UC]. Here we investigated how MNPs the cytokines they produce shape colonic effector cell profile. Methods Colonic or mesenteric lymph node [mLNs] CD4+ isolated from UC Crohn’s disease [CD] patients were stimulated with autologous MNPs. Cytokine expression was assessed by intracytoplasmic staining multiplex ELISA. Unsupervised phenotypic multicolour analysis of performed using...
Abstract Human Slan DCs have been studied in patients with psoriasis, rheumatoid arthritis, cancer, and autoimmune diseases. In this study, we investigated the frequency, phenotype, function of blood, colon, as well mLNs IBD. We first show that frequency circulating CD14dullSlan was reduced CD refractory to immunosuppressive drugs or TNF-α blockers relative untreated CD, UC, healthy subjects. blood patients, expressed CD172a, detected by CD47 fusion protein binding, when compared its lack...
Crohn's disease [CD] and ulcerative colitis [UC] are distinct forms of inflammatory bowel disease. Heterogeneity HLA-DR+SIRPα + mononuclear phagocytes [MNPs], including macrophages [MΦ], monocyte-derived [Mono] cells, dendritic cells [DCs], was reported in gut tissue but not yet investigated mesenteric lymph nodes [MLNs] IBD patients. We here compared the phenotype, function, molecular profile MNPs CD UC MLNs. Cell distribution, morphology, immune transcriptomic [bulk RNAseq]...
The incidence of very-early-onset inflammatory bowel disease (VEO-IBD) and early-onset IBD (EO-IBD) is increasing. Here, we report their phenotype outcomes in a Montreal pediatric cohort.We analyzed data from patients diagnosed with between January 2014 December 2018 the CHU Sainte-Justine. primary endpoint was to compare phenotypes VEO-IBD EO-IBD. secondary endpoints involved comparing rates steroid-free clinical remission (SFCR) at 12 (±2) months (m) post-diagnosis last follow-up.28 (14...
Abstract Monocyte maturation program into macrophages (MΦ) is well defined in murine gut under homeostatic or inflammatory conditions. Obviously, vivo tracking of monocytes inflamed tissues remains difficult humans. Furthermore, vitro models fall short generating the surrogates transient extravasated tissue monocytes. Here, we aimed to unravel environmental cues that replicated human monocyte “waterfall” process by first, tissue‐like monocytes, which were then shifted toward MΦ. Purified...
Division of Gastroenterology, Department Pediatrics, CHU Ste-Justine, Montreal, Quebec Correspondence: Dr Christophe Faure, Gastroenterology and Nutrition, Hopital Sainte-Justine, 3175 Cote Sainte-Catherine, H3T 1C5. Telephone 514-345-4931 ext 2561, fax 514-345-4999, e-mail christophe.faure@umontreal.ca Received for publication May 16, 2014. Accepted June 2014 CASE PRESENTATION Esophageal atresia (EA) is a congenital disorder that affects one in 2500 newborns (1). In the long-term follow-up...
Orofacial granulomatosis (OFG) is a very rare and disabling manifestation of Crohn's disease (CD). Remission orofacial (OCD) difficult to obtain. The aim the study was evaluate efficacy infliximab adalimumab in pediatric patients suffering from OCD. 4 (3 boys) with OCD were treated anti-TNF-α therapy between 2000 2012. Clinical data retrospectively extracted medical charts determine outcome adverse effects therapy. Case 1: 16 year old boy diagnosed OFG at age 11. Subsequently, he presented...
Abstract Background Mononuclear phagocytes (MNPs), including dendritic cells (DCs), monocytes (Mo), and macrophages (Mac), are key inducers of the adaptive immune response. MNPs could circulate between blood, mucosa, mesenteric lymph nodes (MLNs), where they interact with T cells, natural killer (NK) innate lymphoid (ILC), contributing to chronic inflammation. have been previously investigated at transcriptomic level in inflamed gut but their molecular characterization single-cell remains...
Abstract Background Monotherapy with Infliximab (IFX) can be as efficient combotherapy immunomodulators in the treatment and maintenance of remission for children inflammatory bowel disease (IBD) if an early proactive therapeutic drug monitoring strategy is adequately performed. This may allow optimization blood levels IFX order to obtain a sustained clinical response. Purpose study demonstrated that appropriate trough before dose #3 #4 , monotherapy was very inducing remssion at week 52 ....
Abstract Background Monotherapy with infliximab (IFX) could be as efficient combotherapy immunomodulators in the treatment and maintenance of remission for children inflammatory bowel disease (IBD) if a proactive therapeutic drug monitoring strategy is adequately performed. This may allow optimization blood levels IFX order to obtain sustained clinical response. Methods A retrospective study was conducted amongst IBD, aged from, 2 to, 18 years old diagnosed between January, 2018 June, 2020....