A5026208576- GDF15 and Related Biomarkers
- Signaling Pathways in Disease
- Chemokine receptors and signaling
- S100 Proteins and Annexins
- Biomarkers in Disease Mechanisms
- interferon and immune responses
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
Shanghai Institute of Materia Medica
2022-2025
Chinese Academy of Sciences
2022-2025
University of Chinese Academy of Sciences
2025
Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of β amyloid Aβ42 and serves as a for humanin, that protects neuronal cells from damage by Aβ42, implying its involvement in pathogenesis Alzheimer's disease (AD). However, interaction pattern between FPR2 or humanin remains unknown. Here we report structures bound Gi N-formyl (fHN). Combined with functional data, reveal two critical regions govern recognition activity fHN, including polar binding cavity within...
As the only member of CX3C chemokine receptor subfamily, CX3CR1 binds to its sole endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in atherosclerosis, cancer, and neuropathy. However, drug development is hampered partially by lack structural information. Here, we present two cryo–electron microscopy structures CX3CR1-G i1 complexes ligand-free CX3CL1-bound states at 2.8- 3.4-Å resolution, respectively. Together with functional data, reveal key factors that...