A5058162407- Neuroinflammation and Neurodegeneration Mechanisms
- Technology Adoption and User Behaviour
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Consumer Retail Behavior Studies
- Digital Marketing and Social Media
- Agricultural Economics and Practices
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Customer Service Quality and Loyalty
- Consumer Behavior in Brand Consumption and Identification
- Trace Elements in Health
- Traumatic Brain Injury and Neurovascular Disturbances
- Computational Drug Discovery Methods
- Piperaceae Chemical and Biological Studies
- Autism Spectrum Disorder Research
- Synthesis and Characterization of Heterocyclic Compounds
- Gut microbiota and health
- Natural Antidiabetic Agents Studies
- Genetics and Neurodevelopmental Disorders
- Agriculture, Land Use, Rural Development
- Pharmacological Effects of Medicinal Plants
Indo Soviet Friendship College of Pharmacy
2016-2025
Central University of Punjab
2023
Friendship College
2023
Indian Institute of Vegetable Research
2022-2023
Malaviya National Institute of Technology Jaipur
2023
Babu Banarasi Das University
2022
Guru Gobind Singh Indraprastha University
2016-2022
Panjab University
2022
Kumaun University
2022
Lovely Professional University
2017
Incomplete β-oxidation of fatty acids in mitochondria is a feature insulin resistance and type 2 diabetes mellitus (T2DM). Previous studies revealed that plasma concentrations medium- long-chain acylcarnitines (by-products incomplete β-oxidation) are elevated T2DM resistance. In previous study, we reported mixed d,l isomers C12- or C14-carnitine induced an NF-κB-luciferase reporter gene RAW 264.7 cells, suggesting potential activation proinflammatory pathways. Here, determined whether the...
The gut microbiota consists of a group microorganisms required to support the gastrointestinal system. microbiota-gut-brain axis is dynamic bidirectional communication pathway that links cognitive and emotional perception with peripheral intestinal functions. change in architecture increases permeability intestine, activates immune system, changes blood-brain barrier (BBB) permeability, proinflammatory mediators, eventually causes neurodegeneration. increased bowel upset altered BBB cause...
1-Methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that selectively damages dopaminergic neurons in the substantia nigra pars compacta and induces Parkinson's like symptoms rodents. Quercetin (QC) natural polyphenolic bioflavonoid with potent antioxidant anti-inflammatory properties but lacks of clinical attraction due to low oral bioavailability. Piperine well established bioavailability enhancer used pre-clinically improve antioxidants (e.g., Quercetin). Therefore, present...
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with progressive memory loss and cognitive impairment as main clinical features. The multitarget directed ligand (MTDL) strategy explored for the treatment of diseases such cancer AD. Herein, we report synthesis screening 24 N-propargyl-substituted diphenylpyrimidine derivatives MTDLs against acetylcholine/butyrylcholine esterases monoamine oxidase enzymes. In this series, VP1 showed most potent MAO-B...
Quinolinic acid (QA) is an excitotoxin that induces Huntington's-like symptoms in animals and humans. Curcumin (CMN) a well-known antioxidant but the major problem its bioavailability. Therefore, present study was designed to investigate effect of CMN presence piperine against QA-induced excitotoxic cell death rats.QA administered intrastriatally at dose 200 nmol/2 µl saline, bilaterally. (25 50 mg/kg/day, p.o.) combination with (2.5 daily for next 21 days. Body weight behavioral parameters...