A5055545781- Autoimmune Bullous Skin Diseases
- Celiac Disease Research and Management
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Skin and Cellular Biology Research
- Microscopic Colitis
- Quinazolinone synthesis and applications
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Synthesis and Characterization of Heterocyclic Compounds
- Inflammatory Myopathies and Dermatomyositis
- Galectins and Cancer Biology
- Enzyme function and inhibition
- Helicobacter pylori-related gastroenterology studies
- Synthesis of Organic Compounds
- Microbial Metabolites in Food Biotechnology
- Click Chemistry and Applications
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Biosimilars and Bioanalytical Methods
- Eosinophilic Disorders and Syndromes
Central University of Punjab
2018-2025
Chaudhary Devi Lal University
2025
Chaitanya Hospital And Nursing Home
2025
All India Institute of Medical Sciences Raipur
2025
All India Institute of Medical Sciences
2025
All India Institute of Medical Sciences Bhopal
2025
Baba Mastnath University
2024
Chaudhary Ranbir Singh University
2024
Dr. Yashwant Singh Parmar University of Horticulture and Forestry
2023
Hallym University
2023
Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also potent angiogenic effects in vivo . is sufficiently stimulate neovascularization from limbal vessels mouse cornea. Similar VEGF, response corneas induced by intensive, with high density new capillaries. However, outgrowth microvessels stimulated was significantly longer than VEGF. In...
The recently described IgA anti‐endomysial antibodies (IgA‐EmA) are directed against the intermyofibril substance of smooth muscle, which may correspond either to a reticulin‐like structure or surface component muscle fibrils. These occurred in about 80% sera thirty‐eight patients with dermatitis herpetiformis (DH), 70% twenty‐eight coeliac disease and 20% nine other enteropathies. IgG class anti‐gliadin (AGA) also occur each these diseases. Both were detected on monkey oesophagus by...
SUMMARY The immunological markers proposed to supplement intestinal biopsy for the diagnosis of coeliac disease are antigliadin, antireticulin and antiendomysial antibodies. These antibodies have been studied separately or compared as pairs, but no prospective comparison all three in childhood exists. Thirty-four confirmed coeliacs were with nine non-coeliacs pathological small intestines, 32 children a normal histology. Sera examined IgG- IgA-antigliadin (AGA) by ELISA, IgA-antireticulin...
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with progressive memory loss and cognitive impairment as main clinical features. The multitarget directed ligand (MTDL) strategy explored for the treatment of diseases such cancer AD. Herein, we report synthesis screening 24 N-propargyl-substituted diphenylpyrimidine derivatives MTDLs against acetylcholine/butyrylcholine esterases monoamine oxidase enzymes. In this series, VP1 showed most potent MAO-B...
The relationship between celiac disease and juvenile diabetes has long been known. Only a single study in the United States, from Buffalo, New York, reported prevalence of pediatric diabetic population. This was conducted to determine clinical presentation children adolescents with Wisconsin, USA, using serum antiendomysial antibody as screening test.Two hundred eighteen patients (113 males; age range, 4-21 years) 117 age-and gender-matched control participants were tested for immunoglobulin...
Male-type baldness is a common chronic hair loss disorder among males. Male type characterized by stepwise miniaturization of the follicle, due to alteration in cycle dynamics, leading transformation terminal follicle into vellus one. Platelet-rich plasma (PRP) seems be new technique which may improve regrowth. We planned randomized, double-blinded placebo control trial see efficacy PRP with and without topical minoxidil compare standard treatment.The study design was double-blind trial. The...
In recent times, the existence of microplastics in food chain has emerged as a physiological stressor and multifactorial safety issue, necessitating an immediate strategic perspective due to associated human health eco-toxicological risks. To best our knowledge, edible fruit crop facts have not yet been compiled, despite their presence various webs. Due risks with public’s when consuming products (e.g., crops) that contain high concentration microplastic pollutants, approach emerging issue...
Cancer is one of the most prominent causes death worldwide and tubulin a crucial protein cytoskeleton that maintains essential cellular functions including cell division as well signalling, makes an attractive drug target for cancer development. 1,3,4-oxadiazoles disrupt microtubule causing G2-M phase cycle arrest provide anti-proliferative effect. In this study, field-based 3D-QSAR models were developed using 62 bioactive anti-tubulin 1,3,4-oxadiazoles. The best model characterized by PLS...
Alzheimer's disease is a complex neurological disorder linked with multiple pathological hallmarks. The interrelation of therapeutic targets assists in the enhancement cognitive decline through interference overall neuronal transmission. We have synthesized and screened various chromone derivatives as potential multitarget-directed ligands for effective treatment disease. compounds exhibited multipotent activity against AChE, BuChE, MAO-B, amyloid β aggregation. Three potent compounds, i.e.,...
We evaluated the sensitivity and kinetics of serum IgA class anti-endomysial antibodies in diagnosis celiac disease (CD) as established by criteria European Society for Pediatric Gastroenterology Nutrition (ESPGAN). Eighty-four cases that satisfied ESPGAN CD were IgA-EmA titers during various phases establishing diagnosis. Thirty-three infants children <5 years age undergoing intestinal biopsies symptoms 51 previously diagnosed adults. Of 33 children, 11 untreated symptomatic positive at...
Alzheimer’s disease (AD) is a multifactorial neurological disorder characterized by memory loss and cognitive impairment. The currently available single-targeting drugs have miserably failed in the treatment of AD, multi-target directed ligands (MTDLs) are being explored as an alternative strategy. Cholinesterase monoamine oxidase enzymes reported to play crucial role pathology multipotent targeting these two simultaneously under various phases design development. Recent studies revealed...
Alzheimer's disease (AD) is a multifactorial neurological disorder that affects millions of people worldwide.
Twelve 2,4-bis-substituted quinazoline-based compounds were synthesized and screened for antiproliferative tubulin polymerization enhancing potential.
Background: The Euphorbiaceae family comprises over 7,500 species and 300 gen-era, with the castor bean plant, Ricinus communis, being one of most valuable traditional medicinal plants. Phytochemical assessments have shown that R. communis possesses a broad variety chemical compounds interesting pharmacological properties. This plant exhibits numerous beneficial properties, including effects against implantation failure, anti-fertility, antinociceptive, anticancer, antioxidant,...
Acute kidney injury (AKI) is one of the poor prognosticating conditions in intensive care unit (ICU). It increases mortality. Its pathophysiology involves various aspects, such as prerenal, renal, and postrenal components. Many times, it a combination or more etiologies. management challenge, no agent approved for its prevention treatment. comprehensive treatment timely institution renal replacement therapy (RRT) that matter most. To understand prognosis outcome patients with AKI, we...