A5012970936- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Bariatric Surgery and Outcomes
- Maternal and fetal healthcare
- Blood Coagulation and Thrombosis Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Breastfeeding Practices and Influences
- Neurological Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Venous Thromboembolism Diagnosis and Management
- Diabetes Management and Research
- Per- and polyfluoroalkyl substances research
- Healthcare Systems and Practices
- Nausea and vomiting management
- Reproductive Health and Contraception
- Urinary Tract Infections Management
- MicroRNA in disease regulation
- Ectopic Pregnancy Diagnosis and Management
- Genetic Associations and Epidemiology
- Anesthesia and Pain Management
- Healthcare Systems and Public Health
- Neonatal Respiratory Health Research
- Maternal and Perinatal Health Interventions
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2015-2025
St Petersburg University
2020-2025
Saint Petersburg State Pediatric Medical University
2025
We aimed to determine fetal liver perfusion in PGDM and GDM pregnancies assess the relation of ductus venosus (DV) shunt fraction with adverse pregnancy outcomes. conducted a prospective longitudinal observational study including 188 pregnant women: group I—patients pregestational DM (PGDM, n = 86), II—patients gestational (GDM, 44), III—control (n 58). The patients included underwent ultrasound examination at 30+0–40+0 weeks pregnancy. evaluated volumetric blood flow adjusted EFW (Q,...
Background: Chronic hyperglycemia and abnormal glucose variability are established risk factors for perinatal complications. Abnormal fetal growth diabetic fetopathy can be associated not only with carbohydrate metabolism disorders, but also impaired production of cytokines, chemokines, that regulate intercellular interactions. Aim: The aim this study was to evaluate cytokine factor levels in the blood serum pregnant women type 1 diabetes mellitus umbilical cord their neonates, as well...
The present article contains the newest ant most actual version of clinical recommendations “Gestational diabetes mellitus” Russian Ministry Health. This document has been confirmed for period from 2024 until 2026 year. Gestational mellitus is widely known as onset hyperglycaemia during pregnancy that does not responds to criteria manifesting (DM). time next revision year or earlier if new evidentiary material appear. recommendation created due collaboration between Association...
Currently, there is a steady increase in the incidence of diabetes mellitus (DM) global population, which causes an maternal and perinatal mortality. Children born to mothers with DM have high risk not only congenital abnormalities, but also cardiovascular metabolic disorders later life. Fetal growth determined by both nutritional status mother, placental nutrient transfer capacity. Pregnancy complicated associated overgrowth fetus, excess deposition metabolites placenta. The role...
Objective To evaluate serum concentration of 8-isoprostane, nitrotyrosine (NT), and total antioxidant capacity (TAC) in pregnant women with diabetes mellitus (DM) considering preconception planning method correction 11–14 30–34 weeks. Materials methods The study included 130 women: T1DM (n = 40), T2DM 35), gestational (GDM, n 40) the control group 15). concentrations NT, TAC were measured by ELISA methods.Results Elevated 8-isoprostane levels observed all patients DM, but this biomarker's...
To analyze glucose variability and investigate its role as a predictor for preeclampsia development in pregnant women with type 1 diabetes mellitus (T1DM) various insulin therapy regimens.A total of 200 T1DM were included the study. A hundred used continuous subcutaneous infusion (CSII), rest group was administered multiple daily injections (MDI). Continuous monitoring (CGM), index calculation (MAGE, MODD, CONGA, CV), assessment frequency severity conducted.The work results show link between...
To evaluate a level of expression endoglin (Eng), leptin (Lep), placental growth factor (PlGF), and hypoxia-inducible factor-1alpha (HIF-1α) in placenta among women with pre-eclampsia diabetes mellitus (DM), considering the method glycemia correction preconception care.A retrospective cohort study was conducted. A total 124 were divided into following groups: type 1 DM (n = 40), 2DM 31), gestational 33), without (PE) 10) control group 10). The histochemical performed by using primary...
To assess the levels of pregnancy-associated plasma protein-A (PAPP-A) and β-human chorionic gonadotropin (fb-hCG) in cases diabetic pregnancy, to determine whether these biomarkers can be considered significant predictors for macrosomia, preeclampsia (PE), intrauterine growth restriction (IUGR), preterm birth mothers with different types pregestational diabetes mellitus (DM).It was a retrospective cohort study. Study groups were presented: type 1 DM (n = 100), 2 50), controls 25). At 11 + 0...
Hypothesis/aims of study. Diabetes mellitus (DM) is associated with an increased risk obstetric complications, including preterm birth (PB). The incidence rate PB in women DM higher than the general population and amounts to 3040%. Nevertheless, there are still open questions on structure PB, pharmacological approaches its prevention treatment, as well feasibility prolonging timing glucocorticoid therapy reduce perinatal morbidity mortality. objective this study was research features...
Study Objective: To analyse risk factors and perinatal mortality structure in patients with various types of diabetes mellitus (DM) over the last 30 years specialised settings. Design: retrospective single-site cohort study. Materials Methods. We have studied 42 medical records containing cases death foetus or newborn 1988–2018 DM1 (n = 20), DM2 10), gestational DM 12). Results. The most common complication pregnancy was preeclampsia combined chronic placental insufficiency (47.6%). were...
Chronic placental insufficiency remains a major cause of perinatal morbidity and mortality. In this regard, prediction pregnancy complications becomes particularly relevant. Currently, the frequency as result assisted reproductive technology (ART) increases among population. Pregnancies after ART administration compare to naturally occurred are accompanied by higher risk miscarriage well formation insufficiency. Older women with endocrine physical disorder participate in programs most...
AIM: The aim of this study was to compare placental morphological features from women with different types diabetes mellitus considering method DM correction.
 MATERIALS AND METHODS: A retrospective, single-center, cohort carried out. We analyzed examination results 3300 placentas, which made uр the following comparison groups: type 1 on continuous subcutaneous insulin infusion (n = 60), multiple injections 446), 2 diet 95), therapy 134), gestational 1652), 735), preeclampsia 39), and...
Diabetes mellitus (DM) in pregnancy and gestational diabetes remain a considerable cause of complications, fetal macrosomia is among them. Insulin, insulin-like growth factors (IGFs), components their signal-transduction axes belong to the predominant regulators are implicated glucose homeostasis. This study aimed evaluate available evidence on association between IGF axis anthropometric parameters human diabetic pregnancy.PubMed, Medline, Web Science, CNKI databases (1981-2021) were...
Oxidative stress (OS) plays an important role in embryo development, implantation, placentation, fetal development and labour. Diabetes mellitus (DM) is associated with increase OS processes. However, the expression of biomarkers pregnant women DM remains unclear. Based on a literature review, features pro- anti-oxidant systems different types have been established. Pregnancy patients has shown to be characterised by activation This leads overexpression free radicals (peroxynitrite), toxic...
The aim of study was to determine feasible changes placental miRNAs expression profiles revealed by next generation sequencing (NGS) in pregnancies with GDM complicated or not PE. Out 27 miRNAs, studied significantly different (FDR < 0.05) only for his-miR-45a. Comparative analysis reliable differences hsa-miR-4532 (p 0.0001, FDR = 0.0008), hsa-miR-34c-5p 0.0083), and hsa-miR-193b-5p 0.0139) pregnancy PE, without GDM. present results suggest that PE are associated specific alterations the...
Based on the analysis of literature data, role and serum levels main angiogenic (placental growth factor (PlGF)) antiangiogenic vascular factors (endoglin (sENG), soluble fms-like type 1 tyrosine kinase (sFlt-1)) have been assessed in pregnant women with different types diabetes mellitus (DM) both plasma placenta. We evaluated effectiveness administration low doses acetylsalicylic acid for preventing preeclampsia diabetic pregnancy. In addition, using sFlt-1/PlGF PlGF/sENG ratios as possible...
BACKGROUND: The fetal liver plays a central role in energy metabolism and is supplied mainly by the vessels of umbilical-portal venous system. Redistribution blood flow this system key adaptive response fetus to environmental change. AIM: aim study was evaluate hemodynamic redistribution pregnant women with pregestational diabetes mellitus, gestational mellitus healthy women. MATERIALS AND METHODS: This prospective cohort single-center conducted at Research Institute Obstetrics, Gynecology...