A5022139713- Hematopoietic Stem Cell Transplantation
- Multiple Sclerosis Research Studies
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Polyomavirus and related diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Systemic Sclerosis and Related Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Multiple Myeloma Research and Treatments
Benemérita Universidad Autónoma de Puebla
2018-2019
Clínica Ruiz
2018-2019
In order to reset the immune system baseline function, autologous hematopoietic stem cell transplantation (HSCT) has been performed in patients with multiple sclerosis (MS). After June 2015, 617 new consecutive MS were autografted our center non-frozen peripheral blood cells. The autografts on an out-patient basis, after conditioning cyclophosphamide and rituximab. aim of study was assessment both safety efficacy method. study's primary co-end-points recovery granulocyte platelet counts...
Persons with multiple sclerosis are increasingly treated intermediate- or high-dose chemotherapy and a hematopoietic cell autotransplant. This is often done in an inpatient setting using frozen blood grafts.Determine if autotransplant can be safely outpatient refrigerated, non-frozen grafts.We developed protocol actionable graft collected after giving cyclophosphamide, 50 mg/kg/d × 2 days filgrastim, 10 μg/kg/d. A second identical course was given 9 later followed by infusion of cells stored...
The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being dominant autosomal disease with qualitative alterations familial occurrence. It characterized by hyperreactivity increased aggregability in response to low concentrations agonists: epinephrine, adenosine diphosphate, or both. clinical manifestations involve recurrent pregnancy loss, fetal growth retardation. To analyze the localization thrombotic episodes cohort Mexican mestizo patients SPS....
Introduction:The spectrum of multiple sclerosis (MS) among all its clinical types includes a vast number alterations.Of these, respiratory impairment carries big implications since this is an important cause mortality and morbidity.Methods: Here, we present observational study assessment through spirometry in individuals with MS.Subjects who underwent autologous hematopoietic stem cell transplant from interventional were considered to participate.Results: An abnormal pattern was found 147...
Background In an effort to reset the immune system, individuals with multiple sclerosis (MS) have undergone autologous hematopoietic stem cell transplant; this approach has produced promising results in terms of feasibility, efficacy and safety, however, role post-transplant adjuvant therapeutic agents needs be further clarified. Methods Consecutive patients autografted using Mexican method (ClinicalTrials.gov NCT02674217) graft persons MS were prospectively accrued study. All autografts...
Background Intensive chemotherapy and a haematopoietic cell autotransplant is an effective therapy of multiple sclerosis (MS). This often done in inpatient setting using frozen blood cells. Objective Determine if intensive can be safely outpatient refrigerated, non-frozen Methods We developed protocol actionable refrigerated cells collected after giving cyclophosphamide, 50 mg/kg/d x 2 d filgrastim, 10 μg/kg/d. A 2nd identical course cyclophosphamide was given 9 later followed by infusion...