A5026749420- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Veterinary Equine Medical Research
- Cystic Fibrosis Research Advances
- Chemical Synthesis and Analysis
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Appendicitis Diagnosis and Management
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Abdominal Surgery and Complications
- Advanced biosensing and bioanalysis techniques
- Surgical Sutures and Adhesives
- Total Knee Arthroplasty Outcomes
- Veterinary Pharmacology and Anesthesia
- Click Chemistry and Applications
- Clinical practice guidelines implementation
- Green IT and Sustainability
- Vascular Procedures and Complications
- Sulfur-Based Synthesis Techniques
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Veterinary Orthopedics and Neurology
- Organoselenium and organotellurium chemistry
- Prion Diseases and Protein Misfolding
University of Liverpool
1996-2025
Leverhulme Trust
2019-2023
Kansas City University
2015-2017
Proteostasis Therapeutics (United States)
2013-2017
Purdue University West Lafayette
2005-2009
University of Illinois Urbana-Champaign
2009
Rega Institute for Medical Research
2007
Imperial College London
2007
KU Leuven
2007
ImQuest BioSciences (United States)
2007
Sulfenium and selenenium ions undergo a stereospecific transfer from the corresponding three-membered ring species ("-iranium ions") to unactivated alkenes with varying facility. The thiiranium seleniranium hexafluoroantimonates could be generated by treatment of chloro sulfides or selenides silver hexafluoroantimonate, followed removal chloride filtration. Clean (1)H, (13)C, (77)Se NMR spectra recorded for these species. Treatment S-phenylthiiranium ion an alkene leads slow sulfenium group...
Background: The anterolateral ligament (ALL) has been shown to have an important role in rotatory stability of the knee. While there is abundant research on sex-based differences related anterior cruciate (ACL) rupture, a paucity literature such ALL. Purpose: To define any ALL with regard length, width, and thickness. Study Design: Descriptive laboratory study. Methods: was initially evaluated 165 unpaired knees (92 males 65 females after exclusion criteria applied). thickness were measured...
Cystic fibrosis (CF) is a lethal genetic disorder caused by mutation of the cystic transmembrane conductance regulator (CFTR) gene. Despite recent groundbreaking approval genotype-specific small-molecule drugs, significant portion CF patients still lack effective therapeutic options that address underlying cause disease. Through phenotypic high-throughput screen approximately 54,000 small molecules, we identified novel class CFTR modulators called amplifiers. The compound, characteristics...
Abstract Background Surgical site infection (SSI) is a frequent complication following emergency equine laparotomy, negatively impacting welfare, increasing treatment costs and presenting hospital biosecurity risk. Objectives To determine if sutured‐on stent dressing for incisional protection during anaesthetic recovery reduced SSI laparotomy. Study Design Randomised controlled trial. Methods Eligible horses were randomised to (intervention) or textile (control) as the primary component of...
The alkenyldiarylmethanes (ADAMs) are a unique class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that capable inhibiting HIV-1 (RT) through an allosteric mechanism. However, the potential usefulness ADAMs is limited by presence metabolically labile methyl ester moieties hydrolyzed nonspecific esterases present in blood plasma, resulting formation inactive carboxylic acid metabolites. Therefore, to discover stable ADAMs, design and synthesis new with N-methoxy imidoyl halide...
Summary The ‘SiteRite’ is a portable ultrasound imaging system designed to aid vein location during internal jugular cannulation. It was compared the use of anatomical landmarks for easy and gave good quality images, increased speed cannulation, decreased number attempts locate reduced failure rate, although it had no effect on incidence carotid artery puncture.
Non-nucleoside inhibitors of HIV reverse transcriptase (NNRTIs), albeit not the mainstays HIV/AIDS treatment, have become increasingly important in highly active antiretroviral therapy (HAART) due to their unique mechanism action. Several years ago our group identified alkenyldiarylmethanes (ADAMs) as a potent and novel class NNRTIs; however, most compounds were found be metabolically unstable. Subsequent work has led synthesis 33 analogues, with improved metabolic profiles, through...
To describe the surgical treatment, postoperative management, and outcome of a miniature horse undergoing total hip arthroplasty (THA).Case report.A 4-year-old stallion weighing 85 kg.The presented with left coxofemoral luxation ~6 weeks duration. Computed tomography confirmed craniodorsal marked degenerative changes to femoral head. The underwent THA using cementless press fit implants, including an interlocking lateral bolt for stem.The recovered well from anesthesia but suffered coma-like...
Two crystal structures have been solved for separate complexes of alkenyldiarylmethane (ADAM) nonnucleoside reverse transcriptase inhibitors (NNRTI) 3 and 4 with HIV-1 (RT). The reveal inhibitor binding is exclusively hydrophobic in nature the shape inhibitor-bound NNRTI pocket unique among other reported inhibitor-RT structures. Primarily, ADAMs protrude from a large gap back side pocket, placing portions unusually close to polymerase active site allowing form weak hydrogen bond Lys223....
Cystic fibrosis (CF), an inherited genetic disease, is caused by mutation of the Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which encodes ion channel involved in hydration maintenance anion homeostasis. Ninety percent CF patients possess one or more copies F508del CFTR mutation. This disrupts trafficking protein to plasma membrane and diminishes function mature CFTR. Identifying small molecule modulators mutant activity biosynthesis may yield new tools for discovering novel...
Summary A 5‐year‐old gelding used for showing was presented surgical repair of a full‐thickness 15 mm diameter defect in the right pinna, which had occurred as delayed complication following laser excision sarcoid. The resulted progressive deformity ear, and horse considered at risk further injury if became entrapped on fixed object. Two artificial dermis meshes were inserted to encourage formation granulation tissue across defect, commercially available skin expander implanted adjacent...
The alkenyldiarylmethanes are a class of non-nucleoside reverse transcriptase inhibitors that currently being developed as potential antivirals for the treatment HIV infection and AIDS. As part our continuing investigations on alkenyldiarylmethanes, series thioester analogues were prepared in an effort to improve upon metabolic stability parent lead compound. Hydrolysis moieties was consistently observed during ion trap electrospray ionization (ESI) mass spectrometry extent molecular weak...
Background: Surgical site infection (SSI) is a frequent complication following emergency equine laparotomy. It negatively impacts welfare, increases treatment costs and hospital biosecurity risk justifying investigations of ways to reduce SSI incidence. Objectives: To determine if sutured-on stent dressing for anaesthetic recovery reduces in horses Study design: Randomised controlled trial. Methods: Eligible undergoing exploratory laparotomy were enrolled. Horses randomised have...
Summary Background Tissue expansion is a well‐established technique in reconstructive surgery. Self‐inflating tissue expanders (STE) have not been widely adopted by veterinary surgeons, and clinical descriptions of their use horses are lacking. Objective To describe the indications, experiences outcomes series equine cases that used hydrogel‐based STE to assist soft reconstruction. Study design Prospective study. Methods Case details, surgical techniques were recorded for requiring an STE,...
Accuracy of intrasynovial injections can be challenging to assess in a clinical setting horses. Contrast-enhanced ultrasonography (CEUS) using injectate agitated with air has been used determine the success rates synovial human rheumatology.To diagnostic sensitivity and specificity CEUS describe its use.Cadaveric study followed by prospective descriptive observational study.Part 1: was performed following injection methylene-blue solution targeting 13 different anatomical structures from...
Abstract A 3‐week‐old pedigree British blue bull, weighing 70 kg, presented with soft tissue swelling of the distal left forelimb, a discharging sinus associated granulating wound (pressure sore). Involvement metacarpophalangeal joint was suspected. There were also wounds on dorsal aspect both joints and laterally tarsi. Radiography, arthrocentesis, arthroscopy lavage carried out under general anaesthesia external debrided dressed. Intra‐articular antibiotics given at time surgery systemic...