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Research Areas
- Angiogenesis and VEGF in Cancer
- Zebrafish Biomedical Research Applications
- Congenital heart defects research
National Health Research Institutes
2014
The WNK1 (WNK lysine deficient protein kinase 1) is a serine/threonine with emerging roles in cancer. causes hypertension and hyperkalemia when overexpressed cardiovascular defects ablated mice. In this study, the role of Wnk1 angiogenesis was explored using zebrafish model. There are two wnk1 isoforms, wnk1a wnk1b, both contain all functional domains found human protein. Both isoforms expressed embryo at initiation posterior cardinal vein (PCV), similar to fms-related tyrosine 4 (flt4)....
10.1371/journal.pone.0106129
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PLoS ONE
2014-08-29
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