A5086629255- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Organoboron and organosilicon chemistry
- Catalytic Cross-Coupling Reactions
- Analytical Chemistry and Chromatography
- Synthesis and characterization of novel inorganic/organometallic compounds
- Drug Solubulity and Delivery Systems
- Catalytic C–H Functionalization Methods
- Liver Disease Diagnosis and Treatment
- Oxidative Organic Chemistry Reactions
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Inorganic and Organometallic Chemistry
- Ferrocene Chemistry and Applications
- Atrial Fibrillation Management and Outcomes
- Organometallic Complex Synthesis and Catalysis
- Catalytic Alkyne Reactions
- Hepatitis C virus research
- Cardiac Fibrosis and Remodeling
- Hepatitis B Virus Studies
- Cardiac Valve Diseases and Treatments
- Mesoporous Materials and Catalysis
- Cardiac electrophysiology and arrhythmias
Meiji University
2025
Saitama Medical University Hospital
2013-2024
RIKEN Center for Computational Science
2023-2024
National Hospital Organization
2013-2022
Saitama Medical University
2012-2022
Minami Wakayama Medical Center
2013-2022
Nagoya Institute of Technology
2019
Utsunomiya University
2019
Tottori University
1991-2016
Kanadevia (Japan)
2016
Abstract As chiral ligands for transition metal complex catalyzed asymmetric reactions, various kinds of ferrocenylphosphines, which have planar chirality due to 1,2-unsymmetrically substituted ferrocene structure and also a functional group on the side chain nucleus, were prepared. (S)-N,N-dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine [(S)-(R)-PPFA], (S)-N,N-dimethyl-1-[(R)-1′,2-bis(diphenylphosphino)ferrocenyl]ethylamine [(S)-(R)-BPPFA], their dimethylphosphino derivatives...
The enterotoxicity of an El Tor-like hemolysin purified from non-O1 Vibrio cholerae was investigated. Fluid accumulation induced by injection into the ligated intestinal loops in adult rabbits (De test), intraintestinal administration infant (Dutta and oral inoculation suckling mice. accumulated fluid invariably mucous bloody, a histological change mucosa observed. These results suggest that is enterotoxic factor responsible for V. gastroenteritis.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOsmium tetraoxide catalyzed vicinal hydroxylation of higher olefins by using hexacyanoferrate(III) ion as a cooxidantMakoto Minato, Keiji Yamamoto, and Jiro TsujiCite this: J. Org. Chem. 1990, 55, 2, 766–768Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00289a066https://doi.org/10.1021/jo00289a066research-articleACS PublicationsRequest reuse...
Peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily. PPARgamma mRNA is present in cardiac myocytes; however, whether affects hypertrophy remains unknown.We investigated effects of activators on neonatal rat myocytes. Cyclic 4% biaxial mechanical strain caused enlargement myocytes (1.3-fold versus control, P<0.0001), but troglitazone and 15-deoxy-Delta(12-14)-prostaglandin J(2) (15d-PGJ(2)) (10 micromol/L) inhibited this...
The long-term impact of acute self-limited hepatitis B on the liver is unknown. Fourteen patients were recalled at a median 4.2 years (range, 1.8-9.5 years) after onset B. All showed clinical and serologic recovery with circulating surface antigen (HBsAg) clearance. Antibody to HBsAg (anti-HBs) had developed in 12 patients. Nine underwent biopsies 7.2 years, histologic findings evaluated using Ishak scores. Serum samples frozen tissue subjected real-time detection polymerase chain reaction...
Measurements of velocity and attenuation ultrasonic waves are carried out for polystyrene, polymethyl methacrylate, phenol resin, polyethylene, nylon 6 other commercial resins in the temperature from -60°C to 90°C at frequencies 100 kc, 1.46 Mc, 4.38 Mc 7.30 Mc. A correlation between sound megacycle range density is pointed glassy polymers. In case linear polymers, coefficient velocity, β, exhibits a relatively abrupt change glass trasition region T m , which independent frequency agrees...
OBJECTIVE. The aim of this study was to evaluate the usefulness a new commercially available computer-aided diagnosis (CAD) system with an automated method detecting nodules due lung cancers on chest radiograph.
Rodent and human clinical studies have shown that transplantation of bone marrow stem cells to the ischemic myocardium results in improved cardiac function. In this study, cynomolgus monkey acute myocardial infarction was generated by ligating left anterior descending artery, autologous CD34+ were transplanted peri‐ischemic zone. To track vivo fate cells, genetically marked with green fluorescent protein (GFP) using a lentivirus vector before (marking efficiency, 41% on average). The group...
Hemolysin of a non-O1 Vibrio cholerae strain was purified and characterized. The hemolysin gave single protein band on conventional sodium dodecyl sulfate-gel electrophoresis. Its molecular weight estimated as 60,000 by sulfate-polyacrylamide slab gel It had pI 5.7. caused increased vascular permeability rabbit skin rapid death mice intravenous injection also lysed erythrocytes various animal species. An Ouchterlony double diffusion test using antiserum against the indicated that from V....
A cytolysin of ca. 56 kilodaltons has been suggested as a possible virulence factor in Vibrio vulnificus infections. We sequenced the DNA encoding cytolytic activity and found that sequence contained two open reading frames, vvhA vvhB. encoded structural gene for N-terminal amino acid previously reported protein. Regions showed homology to cholerae E1 Tor hemolysin.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric homogeneous hydrosilylation with chiral phosphine-palladium complexesYoshihisa Kiso, Keiji Yamamoto, Kohei Tamao, and Makoto KumadaCite this: J. Am. Chem. Soc. 1972, 94, 12, 4373–4374Publication Date (Print):June 1, 1972Publication History Published online1 May 2002Published inissue 1 June 1972https://doi.org/10.1021/ja00767a074RIGHTS & PERMISSIONSArticle Views1113Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the...
It has been established that the long-term infection of chronic hepatitis C leads to increased risk hepatic fibrosis and hepatocellular carcinoma. Currently, histological diagnosis by invasive painful liver biopsy is gold standard for evaluating stage. Because a side effect or patient inability cope with pain, it difficult assess stage frequently using biopsy. Recently, instead biopsy, many articles have published showing usefulness ultrasound elastography evaluate fibrosis. We also reported...
Abstract —Matrix metalloproteinase-1 (MMP-1), also called interstitial collagenase, may play an important role in the pathogenesis of atherosclerosis and atherosclerotic plaque rupture. We investigated effects fluvastatin on MMP-1 expression human vascular endothelial cells (ECs). The addition decreased basal levels culture media ECs a time-dependent (0 to 48 hours) dose-dependent (10 − 8 10 5 mol/L) manner. On other hand, did not affect tissue inhibitor levels. Collagenolytic activity...
Mechanical overload may change cardiac structure through angiotensin II-dependent and II-independent mechanisms. We investigated the effects of mechanical strain on gene expression tenascin-C, a prominent extracellular molecule in actively remodeling tissues, neonatal rat myocytes. induced tenascin-C mRNA (3.9 ± 0.5-fold, <i>p</i> < 0.01, <i>n</i> = 13) protein an amplitude-dependent manner but did not induce secreted acidic rich cysteine nor fibronectin. RNase protection assay demonstrated...
We investigated the effects of endothelin-1 on nitric oxide synthesis in vascular smooth muscle cells. measured production nitrite, a stable metabolite oxide, and expression inducible synthase mRNA protein cultured rat Incubation cultures with interleukin-1β (10 ng/mL) for 24 hours caused significant increase nitrite production. Endothelin-1 significantly decreased interleukin-1β–induced by cells dose-dependent manner −11 to 10 −8 mol/L). induced cells, whereas showed suppressive effect...