A5065389298- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Nuclear physics research studies
- High-Energy Particle Collisions Research
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Aluminum Alloy Microstructure Properties
- Virus-based gene therapy research
- Nitric Oxide and Endothelin Effects
- Metallurgy and Material Forming
- Renin-Angiotensin System Studies
- Atherosclerosis and Cardiovascular Diseases
- Aluminum Alloys Composites Properties
- Fatigue and fracture mechanics
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Sleep and related disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Quantum, superfluid, helium dynamics
- Superconducting Materials and Applications
- Hydrogen embrittlement and corrosion behaviors in metals
- Atomic and Subatomic Physics Research
- Microstructure and Mechanical Properties of Steels
Kyorin University
2025
Fukui Prefectural Hospital
2014-2024
Proton (United Kingdom)
2014-2023
MSD K.K. (Japan)
2012-2020
Osaka University
2001-2020
Tohoku University
2018
WinnMed
2018
Swedish Medical Center
2018
American Association of Physicists in Medicine
2018
Medical Research Associates
2018
The differential and total cross sections for the dp→3Heη reaction have been measured in a high precision statistics COSY-ANKE experiment near threshold using continuous beam energy ramp up to an excess Q of 11.3 MeV with essentially 100% acceptance. kinematics allowed mean value be determined about 9 keV. Evidence is found effects higher partial waves Q≳4 MeV. very rapid rise section its maximum within 0.5 implies large η3He scattering length hence presence quasibound state extremely close...
The pp→pK+Y0 reaction has been studied for hyperon masses m(Y0)⩽1540MeV/c2 at COSY-Jülich by using a 3.65 GeV/c circulating proton beam incident on an internal hydrogen target. Final states comprising two protons, one positively charged kaon and negatively pion have identified with the ANKE spectrometer. Such configurations are sensitive to production of ground state Λ Σ0 hyperons as well Σ0(1385) Λ(1405) resonances. Applying invariant- missing-mass techniques, overlapping excited could be...
Pulmonary arterial hypertension (PAH) is a fatal disease associated with inflammation and pathological remodeling of the pulmonary artery (PA). Interleukin (IL)-10 pleiotropic antiinflammatory cytokine vasculoprotective properties. Here, we report preventive effects IL-10 on monocrotaline-induced PAH. Three-week-old Wistar rats were intramuscularly injected an adeno-associated virus serotype 1 vector expressing IL-10, followed by monocrotaline injection at 7 weeks old. transduction...
A search for $K^-pp$ bound state (the lightest kaonic nucleus) has been performed using the $\gamma d \rightarrow K^+ \pi^- \rm{X}$ reaction at E$_\gamma$=1.5-2.4 GeV LEPS/SPring-8. The differential cross section of $K^+ \pi^-$ photo-production off deuterium measured first time in this energy region, and a bump structure was searched inclusive missing mass spectrum. statistically significant not observed region from 2.22 to 2.36 GeV/$c^2$, upper limits production were determined be 0.1$-$0.7...
We investigated the effects of endothelin-1 on nitric oxide synthesis in vascular smooth muscle cells. measured production nitrite, a stable metabolite oxide, and expression inducible synthase mRNA protein cultured rat Incubation cultures with interleukin-1β (10 ng/mL) for 24 hours caused significant increase nitrite production. Endothelin-1 significantly decreased interleukin-1β–induced by cells dose-dependent manner −11 to 10 −8 mol/L). induced cells, whereas showed suppressive effect...
The production of phi mesons in the collisions 2.83 GeV protons with C, Cu, Ag, and Au at forward angles has been measured via -> K+K- decay using COSY-ANKE magnetic spectrometer. meson cross section follows a target mass dependence A^0.56+/-0.02 momentum region 0.6-1.6 GeV/c. comparison data model calculations suggests that in-medium width is about an order magnitude larger than its free value.
Background Nitric oxide (NO) has been shown to modulate cardiac function. We investigated the effect of angiotensin II (Ang II) on NO synthase activity in myocytes. Methods and Results Using Griess reagent, we measured production nitrite, a stable metabolite NO, by cultured neonatal rat The expression inducible (iNOS) mRNA was assayed Northern blotting. Incubation myocytes for 24 hours with interleukin-1β (IL-1β) caused significant increase production. Ang significantly augmented synthesis...
The pp->pp phi reaction has been studied at the Cooler Synchrotron COSY-Juelich, using internal beam and ANKE facility. Total cross sections have determined three excess energies epsilon near production threshold. differential section closest to threshold epsilon=18.5 MeV exhibits a clear S-wave dominance as well noticeable effect due proton-proton final state interaction. Taken together with data for pp omega-production, significant enhancement of phi/omega ratio factor 8 is found compared...
The differential and total cross sections for kaon pair production in the pp->ppK+K- reaction have been measured at three beam energies of 2.65, 2.70, 2.83 GeV using ANKE magnetic spectrometer COSY-Juelich accelerator. These near-threshold data are separated into pairs arising from decay phi-meson remainder. For non-phi selection, ratio terms K-p K+p invariant masses is strongly peaked towards low masses. This effect can be described quantitatively by a simple ansatz final state...
Background —Overloading the left ventricle in systole (pressure overload) is associated with a distinct morphological response compared overload diastole (volume overload). Methods and Results —We designed novel computer-controlled experimental system that interfaces biaxially uniform strain electrical pacing, so cellular deformation can be imposed during specified phase of cardiac cycle. Cardiomyocytes were exposed to (4%) either first third (systolic phase) or last (diastolic Strain...
Objectives: Recombinant viral vectors based on the nonpathogenic parvovirus, adeno-associated virus (AAV), have a number of attractive features for gene therapy, including ability to transduce non-dividing cells and its long-term transgene expression. In this study, an AAV vector containing bacterial β-galactosidase (lacZ) was used cultured rat vascular smooth muscle (VSMC) in vitro thoracic aortas ex vivo. Methods: VSMC were transduced with AAV-lacZ at multiplicities infection (MOI) ranging...
The production of $\ensuremath{\varphi}$ mesons in proton collisions with C, Cu, Ag, and Au targets has been studied via the $\ensuremath{\varphi}\ensuremath{\rightarrow}{K}^{+}{K}^{\ensuremath{-}}$ decay at an incident beam energy 2.83 GeV using ANKE detector system COSY. For first time, momentum dependence nuclear transparency ratio, in-medium width, differential cross section for $\ensuremath{\varphi}$-meson forward angles have determined these over range 0.6--1.6 GeV/$c$. There are...
The quasifree $pn\ensuremath{\rightarrow}d\ensuremath{\phi}$ reaction has been studied at the Cooler Synchrotron COSY---J\"ulich, using internal proton beam incident on a deuterium cluster-jet target and detecting fast deuteron in coincidence with ${K}^{+}{K}^{\ensuremath{-}}$ decay of $\ensuremath{\phi}$ meson. energy dependence total differential cross sections are extracted for excess energies up to 80 MeV by determining Fermi momentum neutron an event-by-event basis. Though these...
Differential and total cross sections for the pp -> ppK+K- reaction have been measured at a proton beam energy of 2.83 GeV using COSY-ANKE magnetic spectrometer. Detailed model descriptions fitted to variety one-dimensional distributions permit separation phi section from that non-phi production. The differential spectra show higher partial waves represent majority an excess 76 MeV, whose dependence would then seem require some s-wave phi-p enhancement near threshold. data can be described...
Geant4 is a software toolkit used to simulate the interaction of particles in matter.Monte Carlo simulation useful design particle treatment facilities and quality assurance plans.The therapy framework (PTSIM) Geant4-based for validated using protons carbon-ions.The PTSIM provides common platform model three Japanese proton ion facilities, as well other countries, allowing users who are not experts accurately efficiently run simulations any these pre-built configurations.While has been...
The differential and total cross sections for the $\mathit{dp}\ensuremath{\rightarrow}^{3}\mathrm{He}\ensuremath{\eta}$ reaction have been measured at COSY--ANKE excess energies of 19.5, 39.4, 59.4 MeV over full angular range. results are in line with trends apparent from detailed near-threshold studies also largely agree those CELSIUS, though present data much better coverage near forward backward directions, thus allowing firmer conclusions to be drawn. While 19.5 can described terms $s$-...
To evaluate the effectiveness of CT image-guided proton radiotherapy for prostate cancer by analyzing positioning uncertainty and assessing daily dose change due to anatomical variations.Patients with were treated opposed lateral beams based on a passive scattering method using an in-room system. The system employs single couch both scanning beam delivery. patient was positioned matching boundary between rectum's anterior region identified in images corresponding simulator after bone...
Background and Purpose It has been suggested that the insertion ( I )/deletion D ) polymorphism of angiotensin-converting enzyme (ACE) gene is an independent risk factor for coronary artery disease, but its relation to stroke not yet proven. We investigated association ACE with parental history (PHS) in patients hypertension. Methods studied 70 hypertensive (ambulatory blood pressure >140/90 mm Hg; age, 59±11 years) (n=27) or without (n=43) PHS, defined as either one both parents having...
Measurements of the $\mathit{pd}\ensuremath{\rightarrow}{p}_{\text{sp}}{\mathit{dK}}^{+}{K}^{\ensuremath{-}}$ reaction, where ${p}_{\text{sp}}$ is a spectator proton, have been undertaken at Cooler Synchrotron COSY-J\"ulich by detecting fast deuteron in coincidence with ${K}^{+}{K}^{\ensuremath{-}}$ pair ANKE facility. Although proton beam energy was fixed, moving target neutron allowed values nonresonant quasifree $\mathit{pn}\ensuremath{\rightarrow}{\mathit{dK}}^{+}{K}^{\ensuremath{-}}$...
The efficacy of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) has been reported, but insertion fiducial markers in the liver is usually required. We evaluated and toxicity respiratory-gated PBT without HCC located within 2 cm gastrointestinal tract. From March 2011 to December 2015 at our institution, 40 patients were (median age, 72 years; range, 38–87 years). All underwent a dose 60 80 cobalt gray equivalents (CGE) 20 38 fractions. median follow-up period was 19.9 months...