A5067544399- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
- Reconstructive Surgery and Microvascular Techniques
- Breast Lesions and Carcinomas
- Cancer Risks and Factors
- Women's cancer prevention and management
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- BRCA gene mutations in cancer
- Body Image and Dysmorphia Studies
- Genomics and Rare Diseases
- Nonmelanoma Skin Cancer Studies
- Advanced Proteomics Techniques and Applications
- Thermoregulation and physiological responses
- Multiple and Secondary Primary Cancers
- Infrared Thermography in Medicine
- Extracellular vesicles in disease
- Preterm Birth and Chorioamnionitis
- Management of metastatic bone disease
- Thermography and Photoacoustic Techniques
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
Hospital Nossa Senhora das Graças
2007-2024
Universidade Federal do Paraná
2011-2024
Universidade Positivo
2022
Gene Therapy Laboratory
2020
Hospital de Clínicas Universidade Federal do Paraná
2016-2020
The Princess Grace Hospital
2019
Universidade Regional de Blumenau
2001
Objective: The aim of this study was to report the results prepectoral direct-to implant (DTI) reconstruction in nipple-sparing mastectomy (NSM), without acellular dermal matrices (ADM) or mesh. Methods: Multicenter cohort patients, from 2013 2020, where all sizes and types breasts, either for prophylactic therapeutic surgical purposes were included, except those with previously failed reconstruction, previous radiotherapy severe skin damage, locally advanced breast cancer, gigantomasty,...
Breast cancer (BC) is a heterogeneous disease, and establishing biomarkers essential to patient management. We previously described that extracellular vesicle-derived miRNAs (EV-miRNAs) miR-142-5p, miR-150-5p, miR-320a, miR-4433b-5p in serum discriminated BC from control samples, either alone or combined panel. Using these markers, we intend evaluate whether the same markers identified EVs are also potential tissue serum. Expression analysis using RT-qPCR was performed of 67 breast patients...
In this article, we delineate a loosely selected cohort comprising patients with history of early-onset breast cancer and/or familial occurrence cancer. The aim study was to gain insights into the presence cancer-related gene variants in population from micro-region southern Brazil, specifically Metropolitan Region Curitiba. This area exhibits highly genetically mixed population, mirroring general characteristics Brazilian people.
Abstract In this article, we delineate a loosely selected cohort comprising patients with history of early-onset breast cancer and/or familial occurrence cancer. The aim study was to gain insights into the presence cancer-related gene variants in population from micro-region southern Brazil, specifically Metropolitan Region Curitiba. This area exhibits highly genetically mixed population, mirroring general characteristics Brazilian people. Comprehensive next-generation sequencing (NGS)...
Background: Three-dimensional (3D) imaging using computer simulations is an evolving technology. There a lack of strong data on the use this technology for oncoplastic (OP) and reconstructive surgery. Methods: A prospective, randomized, single-center trial including breast cancer patients undergoing OP or mastectomy with immediate reconstruction implant (IBR) enrolled from November 2019 to October 2021 at Hospital Nossa Senhora das Graças, Breast Unit in Curitiba, Brazil. Both those IBR...
Marking positive lymph nodes (LNs) before neoadjuvant chemotherapy (NAC) may improve the accuracy of sentinel node biopsy (SLNB). The aim this study was to determine feasibility marking LNs with 4% carbon microparticle suspension (CMS) NAC and evaluate if technique would SLNB identification rate.A prospective patients cT1-T4, cN1-N2 breast cancer who underwent US-guided fine-needle aspiration (FNAB) suspected concomitant CMS performed. After NAC, marked those Patent Blue V dye (PBV) were...
Lyophilized cellulose was analysed to verify the degree of inflammatory reaction and axon realignment in sciatic nerve after loss neural substance. Ten mongrel dogs were divided into: Group 1 - cm section which replaced at lesion site; 2 without fragment replacement. The site involved with lyophilized cellulose. 3 -1 sutured epineurally. Motor response started eighth week. Moderate fibrotic seen animals. Groups showed coaptation between graft ongoing axons. In 2, dog regrowth axons through...
A associação de câncer e gravidez é uma situação desafiadora para o médico. Normalmente necessário uso quimioterapia radioterapia, dependendo do tipo estádio em que diagnosticado. pode oferecer riscos à saúde fetal e, por outro lado, se não for realizado nenhum tratamento até nascimento, a vida da mãe ficar risco. Inicialmente, acreditava-se preocupação deveria ser com mãe, considerando os fetais. Este conceito vem sofrendo mudanças, na tentativa harmonizar adequado preservação integridade...
RESUMO Introdução: O uso de marcadores na axila antes da terapia sistêmica neoadjuvante (TSN) é um tema controverso em mulheres com linfonodos (LN) acometidos. Diversos foram utilizados resultando uma redução taxa falso negativo ao comparar o linfonodo sentinela, melhorando a acurácia. Este estudo tem como propósito analisar os resultados oncológicos que passaram por dissecção axilar seletiva marcação prévia à usando carvão 4% e sua relação LN sentinela. Métodos: Foram selecionadas pacientes...
The use of axillary marking prior to Neoadjuvant Systemic Therapy (NST) is a controversial matter regarding patients with positive Lymph Nodes (LN). Several methods were tested make possible the decrease false negative rate in comparison sentinel lymph node adding more accuracy results. This study aims evaluate oncological outcomes who had undergone selective dissection 4% carbon before TSN.
Introduction: According to the cancer stem-cell theory, tumors originate from a small population of stem cells, which lose mechanism self-regulation and begin differentiate proliferate indefinitely.The CD44 + /CD24 -phenotype may be considered marker in breast cancer.Objective: To evaluate correlation between different molecular subtypes invasive ductal carcinoma samples.Methods: The expression CD44, CD44v6, CD24 markers was investigated 133 cases mammary with immunohistochemistry....
Abstract Background: The use of axillary marking before neoadjuvant systemic therapy (NST) is the standard care in patients with positive lymph nodes (LN). Several methods have been tested leading to reduced false negative rate compared sentinel node biopsy (SLNB). With increase therapies residual disease, it necessary improve accuracy assessment. aim this study was evaluate oncological outcomes undergoing targeted dissection LN pre-NST marked 4% carbon marker, secondary objective...
Background Routine use of magnetic resonance imaging (MRI) in the staging patients with early breast cancer is still controversial. Oncoplastic surgery (OP) allows for wider resections without compromising aesthetic results. This study aimed to assess impact preoperative MRI on surgical planning and indications mastectomy. Methods Prospective including T1-T2 treated between January 2019 December 2020 Breast Unit Hospital Nossa Senhora das Graças Curitiba, Brazil. All had indication...
Infection and exposure of the implant are some most common concerning complications after implant-based breast reconstruction. Currently, there is no consensus on management these complications. The aim present study was to review our cases a clinical protocol. We conducted retrospective consecutive patients submitted reconstruction between 2014 2016. All were managed according specific structured Implant occurred in 33 out 277 (11.9%) reconstructions. Among these, two had history...
A pesquisa visa determinar a evolução do estadiamento e tratamento cirúrgico em pacientes com câncer de mama uma clínica privada, nos últimos 40 anos.Métodos: Estudo observacional descritivo retrospectivo, por meio da análise estatística dos prontuários 2105 atendidas privada
Objective: The use of axillary marking before neoadjuvant systemic therapy (NST) is a field controversy in patients with positive lymph nodes (LNs). Several methods were tested leading to reduction the false negative rate compared sentinel node (SLN), adding precision. aim this study evaluate oncological outcomes undergoing selective dissection pre-NST 4% carbon. Methodology: A prospective was carried out cT1–T4 and cN1–N2 breast cancer who underwent analysis suspected LNs concomitant After...
Abstract Introduction: Surgery is the mainstay treatment of breast cancer and has been improving in aesthetic outcomes even locally advanced disease. Radical mastectomies are being replaced by less aggressive surgeries with immediate reconstruction. Nipple-Sparing Mastectomy (NSM) preserves Nipple Areolar Complex (NAC) along entire skin envelope associated better results quality life, patient satisfaction. Since NSM a relatively recent technique few studies have shown feasibility after...