Abstract Colorectal cancer (CRC) is one of the leading causes cancer‐related death worldwide. Currently, an increasing evidence showed that circular RNAs (circRNAs) play important roles in tumor progression. However, effects and underlying mechanisms circRNAs CRC progression remain unclear. In present study, through circRNA high‐throughput sequencing quantitative real‐time polymerase chain reaction, we identified hsa_circ_0136666 was significantly overexpressed tissues cell lines. High...

Long non-coding RNAs (lncRNAs) play important roles in the progression of cervical cancer (CC). However, and underlying molecular mechanisms lncRNAs CC remain unclear. In current study, we discovered a new lncRNA MIR210HG which was upregulated tissues through microarray. The upregulation associated with advanced FIGO stage, metastasis, poor prognosis patients. Function assays showed that inhibition significantly suppressed proliferation, invasion, epithelial-mesenchymal transition (EMT)...

Abstract Cervical cancer is a malignant tumor of the cervix in women. However, pathogenesis cervical has not been fully understood. N6‐methyladenosine (m6A) kind RNA modification that plays critical role development. We aim to find out possible m6A regulatory mechanism fat mass and obesity‐associated protein (FTO) on development cancer. The proliferative capacity cells was detected by 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyl‐2H‐tetrazolium bromide (MTT), colony formation...

Compelling evidence shows that deregulated microRNAs (miRNAs) are important regulators in the progression of melanoma. miR-145-5p has been suggested to exhibit antitumorigenic activity However, molecular mechanism underlying biological melanoma remains be further understood. Herein, quantitative real-time polymerase chain reaction was used examine expression malignant tissues and cells. The interaction between toll-like receptor 4 (TLR4) explored by bioinformatics analyses, luciferase...

Expression of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), signal transducer activator transcription-3 (STAT3) vascular endothelial growth factor-C (VEGF-C) their relationship with clinico­pathological features prognostic ability was determined using immunohistochemistry in 68 cases colorectal cancer follow-up data. Kaplan-Meier survival analysis performed the value univariate analysis. PTEN, STAT3 VEGF-C expression detected 32.4, 60.3 63.2% carcinoma 90.0, 0 0% normal...

Aberrant promoter methylation has been considered as a potential molecular marker for gastric cancer (GC). However, the role of FLNC, THBS1, and UCHL1 in development progression GC not explored.The status UCHL1, DLEC1 was assessed by quantitative methylation-specific PCR (QMSP) serum 82 patients, 46 chronic atrophic gastritis (CAG) subjects, 40 healthy controls.All four genes had significantly higher levels patients than CAG control subjects. only correlated with tumor stage lymph node...

ABSTRACT Human epididymis protein 4 (HE4) is well known to be a predictor of ovarian cancer clinically. HE4 reported play crucial roles in progression and metastasis. The purpose the present study was explore its biological role molecular mechanism cancer. In our study, we found that expression levels tissues, serum urine were upregulated compared healthy benign groups. elevated cells. Knockdown dampened cell proliferation Ki67 expression, as enhanced apoptosis, caspase-3 activity...

The present study aimed to assess the expression of endoplasmic reticulum oxidoreductin-1-like (ERO1L) in gastric cancer and determine its association with patient prognosis. A total 105 patients undergoing radical gastrectomy were selected for current study. Gastric tissues (the observation group) normal tissue adjacent carcinoma control resected from patients. Levels ERO1L mRNA protein tumor detected using reverse transcription-quantitative polymerase chain reaction, western blotting...

The present study aimed to investigate the expression of Golgi phosphoprotein-3 (GOLPH3) protein in colon cancer tissues and association with prognosis patients. In total, 98 patients admitted First Affiliated Hospital Henan University Science Technology for surgery between June 2011 2013 were taken as observation group. addition, 15 healthy individuals, determined by enteroscopy, control expressions GOLPH3 mRNA detected reverse transcription-polymerase chain reaction immunohistochemistry,...

Objective To investigate tumor and pregnancy outcomes after fertility-sparing surgery for cervical cancer. Methods A total of 83 patients with cancer who received at 10 gynecologic research centers in Henan Province were enrolled from January 2010 to June 2016. Clinical data follow-up results collected. Of them, 78 had squamous carcinoma five adenocarcinoma. International Federation Gynecology Obstetrics (2009) staging showed that 26 stage IA1, 11 IA2, 46 IBI. Seventy-two underwent radical...

e15057 Background: Gastric cardia cancer is one of the most common malignancies in Henan, China. Surgery currently considered as treatment choice for gastric adenocarcinoma(GCA), Postoperative nutritional support was shown to reduce incidence complications and shorten length post operational hospital stay. Recently, early enteral feeding (EEN) has become a standard after gastrointestinal surgery. However, impact EEN on immune function postoperative GCA patients not yet been elucidated. In...

Abstract Cervical cancer (CC) is associated with elevated prevalent rates. Circular RNAs (circRNAs) play vital functions in the pathogenesis of various cancers, such as CC. Here, we evaluated function and molecular mechanisms hsa_circ_0084904 (circKIAA1429) CC progression. Analysis dataset GSE102686 showed that expressions were elevated. Function assays found knockdown repressed cell proliferation, formation colonies, well invasion capacities vitro . In vivo , it reduced tumor Furthermore,...

Abstract Background Circular RNAs (circRNAs), a new type of non-coding RNA, have been demonstrated to play critical roles in the progression various malignant cancers. In present study, we identified circRNA termed as circTADA2A which was hypothesized that may be significantly up-regulated OC tissues and cell lines. Results The results revealed ectopic expression promoted proliferation, migration, invasion colony formation ability cells. Constantly, silencing inhibited those Furthermore,...