A5102670804- Soybean genetics and cultivation
- Plant Gene Expression Analysis
- Tryptophan and brain disorders
- Gear and Bearing Dynamics Analysis
- Plant Stress Responses and Tolerance
- RNA Research and Splicing
- Gut microbiota and health
- Single-cell and spatial transcriptomics
- Lipid metabolism and biosynthesis
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- GABA and Rice Research
- X-ray Diffraction in Crystallography
- RNA and protein synthesis mechanisms
- Tribology and Lubrication Engineering
- Mechanical Failure Analysis and Simulation
- Crystallization and Solubility Studies
Yunnan Open University
2025
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation the development more effective therapies. Here, we performed single-cell dissection schizophrenia-associated transcriptomic changes in human prefrontal cortex across 140 individuals two independent cohorts. Excitatory neurons were most affected cell group, with transcriptional converging on neurodevelopment synapse-related molecular pathways. Transcriptional alterations included known genetic risk...
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays primary human cells from mid-gestation cortex cerebral organoids, we interrogated the cis-regulatory activity 102,767 open chromatin regions, including thousands sequences with cell type-specific accessibility variants associated brain regulation. In cells, identified 46,802 active enhancer 164 that alter activity. Activity was comparable...
The kinesin (KIN) gene family is a subgroup of motor proteins. It plays critical role in plant development and responses to environmental stresses. However, their function soybean salt tolerance has yet be clearly defined. This study employed bioinformatics approaches identified 139 members the genome. These genes were classified into 10 subgroups, unevenly distributed across chromosomes. promoter regions GmKIN harbored several stress-responsive elements, segmental duplication was primary...
The GS3 protein is a G widely conserved in plants, playing pivotal role growth, development, and stress responses. With the sequence of AT1/GS3 gene sorghum as query, this study identified five family members soybean genome database designated GmGS3-1 to GmGS3-5. Promoter cis-element analysis suggested that implicated responses abiotic stress. Additionally, collinearity indicated genes are subject purifying selection. Transcriptomic data revealed nuclear-localized highly expressed root...
The Aldehyde Dehydrogenase (ALDH) superfamily comprises a group of NAD+ or NADP+-dependent enzymes that play essential roles in responding to abiotic stresses plants. In Brassica napus L., however, the increasing frequency extremely low temperatures during winter recent years has significantly affected both yield and quality. This study conducted genome-wide screening ALDH genes, analyzing their gene structures, evolutionary relationships, protein physicochemical properties, expression...