Immunogold labeling was used to localize the core protein of small dermatan sulfate proteoglycan (DS-PG) on surface cultured human fibroblasts. At 4 degrees C, DS-PG uniformly distributed over cell surface. 37 gold particles either became rearranged in form clusters or remained associated with fibrils. Double-label immunocytochemistry indicated co-distribution and fibronectin In an enzyme-linked immunosorbent assay, binding from fibroblast secretions its occurred at pH 7.4 physiological...

Abstract Background Allergy immunotherapy ( AIT ) is the only treatment for allergic rhinitis AR and/or asthma AA with long‐term efficacy. However, there are few real‐life data on progression of in patients receiving . Objectives To assess real‐world, efficacy grass pollen sublingual SLIT tablets and their impact onset progression. Methods In a retrospective analysis German longitudinal prescription database, treated were compared control group not having received Multiple regression was...

Real-world evidence is sparse on the benefits of allergen immunotherapy [AIT; subcutaneous/sublingual (SCIT/SLIT)], only disease-modifying intervention for allergic rhinitis (AR) with long-term efficacy. This real-life study evaluated effect six AITs (native pollen SLIT/SCIT, four allergoid SCITs) vs symptomatic medication use, AR symptoms and asthma symptoms/onset, in patients birch pollen-associated and/or asthma.

Abstract Background The objective of this study was to analyze the effectiveness allergen immunotherapy (AIT) with an allergoid in treatment house dust mites (HDM)‐induced allergic rhinitis and/or asthma based on recent real‐life data. outcomes were measured using incidence and consumption corresponding medications as indicator persisting symptoms. Methods In retrospective cohort analysis a German longitudinal prescription database, patients who received at least two relevant mite AIT...

Abstract Background The German Therapy Allergen Ordinance (TAO) triggered an ongoing upheaval in the market for house dust mite (HDM) allergen immunotherapy (AIT) products. Three HDM subcutaneous AIT (SCIT) products hold approval Germany and therefore will be available after scheduled completion of TAO procedure 2026. In general, data from clinical trials on long‐term effectiveness are rare. We evaluated real‐world (RWD) a retrospective, observational cohort study based longitudinal claims...

Abstract The Gravity Recovery and Climate Experiment (GRACE) mission has enabled mass changes transports in the hydrosphere, cryosphere oceans to be quantified with unprecedented resolution. However, while this legacy is currently being continued GRACE Follow-On (GRACE-FO) there a gap of 11 months between end start GRACE-FO which must addressed. Here we bridge by combining time-variable, low-resolution gravity models derived from European Space Agency’s Swarm satellites dominating spatial...

Article Location of Heparin-Binding Sites Fibronectin. Detection a hitherto Unrecognized Transamidase Sensitive Site was published on January 1, 1981 in the journal Biological Chemistry (volume 362, issue 1).

Allergen immunotherapy (AIT), when continued for 3 years, is the only disease-modifying treatment AR and asthma. Adherence a key to ensure effectiveness, poor adherence contraindication AIT. The objective of this study was evaluate real-world AIT with subcutaneous (SCIT) sublingual (SLIT) preparations in patients allergic grass or tree pollen. impact on consumption asthma rhinitis medication also analyzed.In retrospective cohort analysis German longitudinal prescription database, pollen...

Abstract Background and purpose Several epidemiological studies from Taiwan, all using the same data resource, found significant associations between herpes virus infection, antiherpetic medication, subsequent dementia. We conducted a multicenter observational cohort study health registry Wales, Germany, Scotland, Denmark to investigate potential medication incident dementia, also comprehensively such broken down according type dose, of virus, dementia subtype. Methods A total 2.5 million...

Patients with allergic rhinitis (AR) and/or mild or moderate asthma derived from birch-family pollen allergy can be treated liquid sublingual immunotherapy (SLIT-liquid). This study evaluated the impact of two SLIT extracts on AR and progression onset in these patients. was a sub-analysis retrospective, longitudinal comparative cohort that used German prescription database. 3-tree (birch/alder/hazel) birch-only SLIT-liquid followed up for to 6 years after treatment were compared controls...

Fibronectin (FN) is a multidomain extracellular matrix protein that induces attachment and chemotactic migration of fibroblastic cells. In this study we analyzed the molecular determinants involved in FN-induced normal SV40-transformed 3T3 Two different monoclonal antibodies to cell-binding site FN blocked chemotaxis 140-kD fragment (Ca 140) containing domain. A antibody determinant distant from did not affect chemotaxis. synthetic tetrapeptide, RGDS, which represents major cell-attachment...

Abstract Introduction Allergic rhinitis (AR) is a widespread disease with increasing prevalence in developed countries. The only treatment that tackles the underlying causes allergen immunotherapy (AIT). This performed through two application routes, subcutaneous (SCIT) or sublingual (SLIT). However, persistence during long course of over 3 years key for efficacy this option. impaired adherence significantly impacts public health resources. aim study was to assess AIT both routes. Methods...

Preliminary data suggest that dipeptidyl peptidase-4 (DPP-4) inhibitors may reduce microvascular events, but there is a little evidence to support this from adequate real-world studies. This study aimed compare outcomes between patients-prescribed vildagliptin and those prescribed sulfonylurea (SU).This retrospective cohort was conducted on large sample the German electronic medical records database IMS Lifelink Disease Analyzer. We used propensity score-matched samples of patients either or...

Two monoclonal mouse antibodies against human plasma fibronectin were compared in their reactivity for proteolytic fragments of the antigen by enzyme immunoassay and immunoblotting. These shown to react with two different structures within a short segment (about 30 kDa) located about one‐third away from C‐terminus chains.

Article Early and Late Cathepsin D-Derived Fragments of Fibronectin Containing the C-terminal Interchain Disulfide Cross-Link was published on January 1, 1982 in journal Biological Chemistry (volume 363, issue 1).

A New Atractyligenine Glycoside from Green Coffee-beans so far unknown glycoside was isolated green coffee-beans. Its structure determined by spectral data and chemical reactions to be 2-O-(2-O-isovaleryl-β-D-glucopyranosyl)atractyli genine (4).

This retrospective database analysis complements previous research to understand treatment patterns for German patients newly-initiating or switching subsequent GLP-1 RAs.Adult (≥18 years) initiating RA (Cohort 1 [C1]) from a 2 [C2]) exenatide twice-daily (exBID), once-weekly (exQW), dulaglutide (DULA), liraglutide (LIRA) were included in this using IQVIA LRx January 1, 2014-March 31, 2017. Patients required have ≥1 oral anti-hyperglycemic prescription during the 6-month pre-index period and...

Maintenance treatment strategies in COPD recommend inhaled corticosteroid (ICS) + long-acting muscarinic antagonist (LAMA) β2-agonist (LABA) triple therapy after initial dual therapy. Little is known about how pathways to vary across countries clinical practice. This multi-country, retrospective cohort study (conducted 1 January 2005–1 May 2016) included patients with a diagnosis, and (UK only) evidence of smoking history, or (France, Italy, Germany, Australia) an indicator confirming first...