Manuel Sobrinho Simões

ORCID: 0000-0002-2854-8460
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About
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Research Areas
  • Acute Myeloid Leukemia Research
  • Multiple Myeloma Research and Treatments
  • Drug-Induced Hepatotoxicity and Protection
  • Advanced biosensing and bioanalysis techniques
  • Liver Diseases and Immunity
  • Health and Medical Research Impacts
  • Immune cells in cancer
  • SARS-CoV-2 and COVID-19 Research
  • Leprosy Research and Treatment
  • Berberine and alkaloids research
  • Extracellular vesicles in disease
  • Analytical Chemistry and Sensors
  • Acute Lymphoblastic Leukemia research
  • Molecular Junctions and Nanostructures
  • Hepatitis Viruses Studies and Epidemiology
  • Science and Science Education
  • Information Science and Libraries
  • Telomeres, Telomerase, and Senescence
  • Hematopoietic Stem Cell Transplantation
  • Education and Public Policy

Universidade do Porto
2012-2025

Hospital de São João
2011-2024

IPO Porto
2012-2024

Purpose: Many chemotherapy drugs have the potential for producing liver damage, though they occur rarely and are deemed idiosyncratic, believed to be attributable host response possible immunologic mechanism. Thalidomide is a synthetic derivative of glutamic acid used in myeloma myelodysplastic syndromes; hepatotoxicity considered very rare, with 7 cases described literature. We present case 77 year-old male unremarkable past medical history, admitted our hospital two months earlier acute...

10.14309/00000434-201110002-00812 article EN The American Journal of Gastroenterology 2011-10-01

percentage, a semi-quantitative evaluation of Glasgow Microenvironment Score 7 was performed.Also, Prognostic Score, that is widely known as systemic inflammatory-based marker, determined for each patient. 8Results: Diabetic patients presented significant higher glycaemia than the control (190.1 ± 13.6 mg/dL vs 98.2 3.6 mg/dL, p < 0.001, respectively).Decreased survival rates were observed in diabetic (611.5 916.0, = ns).Tumours exhibited increased fibrosis relatively to adjacent mucosa both...

10.1016/j.pbj.2017.07.121 article EN cc-by-nc-nd Porto Biomedical Journal 2017-09-01

10.17346/se.vol31.452 article PT cc-by-nc-sa Deleted Journal 2022-03-31
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