A5003776604- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Quantum Dots Synthesis And Properties
- Crystallography and molecular interactions
- Advanced biosensing and bioanalysis techniques
- Molecular Junctions and Nanostructures
- bioluminescence and chemiluminescence research
- Drug Transport and Resistance Mechanisms
- Surface Chemistry and Catalysis
- Chalcogenide Semiconductor Thin Films
- Nanocluster Synthesis and Applications
- Cancer-related Molecular Pathways
- Porphyrin and Phthalocyanine Chemistry
Royal College of Surgeons in Ireland
2019-2022
Trinity College Dublin
2017
Trinity College
2014
Core/shell quantum dots (QDs) are of high scientific and technological importance as these nanomaterials have found a number valuable applications. In this paper, we investigated the dependence optical activity photoluminescence upon CdS shell thickness in range core-shell structured CdSe/CdS QDs capped with chiral ligands. For our study, five samples were synthesized utilizing successive ion layer adsorption reaction to vary from 0.5 2 nm, 2.8 nm diameter CdSe core. Following this, ligand...
Chirality strongly influences many biological properties of materials, such as cell accumulation, enzymatic activity, and toxicity. In the past decade, it has been shown that quantum dots (QDs), fluorescent semiconductor nanoparticles with unique optical properties, can demonstrate activity due to chiral ligands bound on their surface. Optically active QDs could find potential applications in biomedical research, therapy, diagnostics. Consequently, is very important investigate interaction...
The first example of a Pt complex GANT61, hedgehog (Hh) pathway inhibitor is reported. Reaction cis-[Pt(II)Cl2(dmso)2] with one equivalent 4-pyridine carboxaldehyde (4-PCA, control ligand) or GANT61 (Hh inhibitor) in acetone at rt for 30 minutes afforded trans-[Pt(II)Cl2(dmso)(4-PCA)] (1) and trans-[Pt(II)Cl2(dmso)(GANT61)] (2) respectively, where 4-PCA are N-donor ligands. structures 1 2 were fully characterised by elemental analysis, 1H NMR, 13C NMR IR spectroscopy X-ray crystallography....
GANT61-D is an important hedgehog pathway inhibitor and interesting ligand candidate for metal coordination. The first examples of complexes the potent are described. reaction Ni(II), Pd(II), Pt(II) precursors with gave [NiII(GANT61-D)(OH2)3(μ2-SO4)(μ3-SO4)] (1), [PdII(Cl)(GANT61-D)]Cl (2), [PtII(Cl)(GANT61-D)]Cl, [PtII(CBDCA-2H)(GANT61-D)]. X-ray crystal structure analysis revealed that a versatile N-donor can act as bidentate via diaminopropane (DAP) N atoms or tridentate DAP one...
Abstract Review: 67 refs.