A5056247934- Hepatitis Viruses Studies and Epidemiology
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Malaria Research and Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- vaccines and immunoinformatics approaches
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug Transport and Resistance Mechanisms
- Complement system in diseases
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral Infections and Immunology Research
- Viral Infections and Vectors
- Mosquito-borne diseases and control
Cleveland Clinic
2025
Gauhati University
2017-2020
Abstract The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of deaths with thousands confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes the 2019‐nCoV surface glycoprotein. Also, interactions between identified CTL their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent China were studied by molecular...
Reactivation of latent human cytomegalovirus (CMV) can lead to severe complications in individuals with dysregulated immune systems. While antiviral therapies for CMV are approved, these compounds limited by their toxicity and inability specifically target the reservoir or prevent reactivation. Herein we show that reactivation Kasumi-3 cells, a CD34 + hematopoietic cell line, requires mitogen-activated protein kinase (MAPK) activation. Importantly, pharmacological inhibition MAPK signaling...
The study explored the role of differential RANTES concentrations, its receptor CCR5 expression and resulting immunomodulation in pathogenesis and/or recovery from falciparum malaria. population included cases uncomplicated malaria (UC-M, N=128, enrolled on follow-up basis), severe (SM, N=25), healthy controls (N=112). Serum TNF-α levels were evaluated by ELISA. Monocyte activation profile studied flow cytometry. Differential mRNA was real-time PCR. Blood parasite count registered...
Abstract microRNAs (miRNAs) are small, noncoding RNAs which regulate eukaryotic gene expression via RNA interference pathway. Recently, miRNAs have been identified in a number of viruses with current evidence suggesting that they both virus and host. This makes viral potential targets clinical intervention, the possibility inhibiting aberrant host associated disease. In this study, computational approaches were taken to scan hepatitis E (HEV) genome for putative pre‐miRNA molecules, then...
Abstract We aimed to evaluate the significance of RANTES‐CCR5 axis and resulting immunomodulatory status in Dengue pathogenesis involving a Guwahati, India based population where cases have increased alarmingly. An CC‐chemokine receptor type 5 (CCR5) messenger RNA expression CCR5 positive cell count profile was observed cases, highest being severe cases. ligand RANTES significantly decreased inversely correlated with viremia fold change Monocytes are involved virus homing replication. Its...
The innate immune response is the first line of defense against invading pathogens, including betaherpesvirus, human cytomegalovirus (CMV). host acts as defense, and CMV, like other viruses, has consequently evolved multiple mechanisms to manipulate interferon (IFN) responses. DEAD-box Helicase 41 (DDX41) an intracellular dsDNA sensor that, upon activation by Bruton's tyrosine kinase (BTK), triggers type I IFN production through Stimulator Interferon Genes (STING) signaling pathway. Here, we...
Fulminant hepatic failure (FHF) is a lethal manifestation of hepatitis A virus (HAV) infection, whose underlying mechanisms are poorly understood. We aimed to evaluate the importance modulation RANTES-chemokine receptor type 5 (CCR5) signaling axis and its immunomodulatory effects in directing disease pathogenesis using an silico, vitro patient cohort-based approach. In silico interaction studies were performed computation approaches with suitable software. Differential expression relevant...