A5051750480- Pregnancy and preeclampsia studies
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Preterm Birth and Chorioamnionitis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Malaria Research and Control
- Folate and B Vitamins Research
- Cervical Cancer and HPV Research
- Advanced biosensing and bioanalysis techniques
- Rheumatoid Arthritis Research and Therapies
- Pregnancy-related medical research
- Ethnobotanical and Medicinal Plants Studies
- Telomeres, Telomerase, and Senescence
- Congenital Anomalies and Fetal Surgery
- Viral gastroenteritis research and epidemiology
- DNA Repair Mechanisms
- MicroRNA in disease regulation
Gauhati University
2015-2024
Assam University
2014
Bodoland University
2014
Govind Ballabh Pant Hospital
2007-2013
Institute of Liver and Biliary Sciences
2012
University of Delhi
2010
Harper University Hospital
2010
Detroit Medical Center
2010
Sriram Chandra Bhanja Medical College Hospital
1983
Abstract The 2019 novel coronavirus (2019‐nCoV) outbreak has caused a large number of deaths with thousands confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes the 2019‐nCoV surface glycoprotein. Also, interactions between identified CTL their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent China were studied by molecular...
Acute care physical therapy is a rapidly evolving practice area, but little known about the skills, knowledge, and behaviors necessary for clinician to be most effective in this area.The objective of study was perform first nationwide survey acute therapists validate skill, behavior sets that reflect parameters specific therapy.A format used.The Care Physical Therapy Practice Analysis Survey created on basis current literature consensus 9-member Subject Matter Expert (SME) Group. The...
Preterm delivery (PTD) is one of the most significant contributors to neonatal mortality, morbidity, and long-term adverse consequences for health; with highest prevalence reported from India. The incidence PTD alarmingly very high in Northeast objective present study evaluate associative role MTHFR gene polymorphism progesterone receptor (PR) mutation (PROGINS) susceptibility PTD, negative pregnancy outcome low birth weights (LBW) Indian population.A total 209 cases {extreme preterm (< 28...
Background As per WHO, Cervical cancer (CaCx) is a global issue, being the fourth common in women with incidence rate of 13.1 1 lakh globally and accounting for 311000 deaths year 2018 itself globally. The molecular pathogenesis Human papillomavirus (HPV) infected cases inconclusive. detection factors leading to progression CaCx can be important diagnosis management disease. p53 known tumor suppressor gene having regulative role cell cycle has been highlighted as key factor prevention but...
Equisetum diffusum D. Don commonly known as 'Himalayan horsetail', has been traditionally used in the treatment of back pain, bone fracture and dislocation, arthritis by various tribal communities India. Our previous study confirmed anti-inflammatory efficacy plant through silico, vitro, vivo model studies. Therefore, current research is focused on safety dose evaluation for first-time whole-plant methanol extract (EDME) E. appropriate approaches.
OBJECTIVES: CD4+ regulatory T cells (Tregs) seem to have a key role in persistence of hepatitis B virus (HBV) infection. Notch and transforming growth factor (TGF-β) signaling independently help the differentiation regulation CD4+T cells, including T-helper (TH) 1, TH2, Tregs. Whether, two pathways modulatory on different stages HBV infection severity liver disease is not clear. We investigated TGF-β families' gene expression peripheral blood intrahepatic lymphocytes patients with chronic...
Multiple factors are associated with human papillomavirus (HPV) infection related cervical anomalies and its progression to carcinoma (CaCx), but data vary respect the underlying HPV genotype population being studied. No available regarding role of immunological imbalance in infected CaCx pathogenesis from Northeast India, which has an ethnically distinct population, was aimed be addressed through this study. The study included 76 cases, 25 intraepithelial neoplasia (CIN) 50 healthy female...
The present study was undertaken to screen the molecular epidemiology of Hepatitis A virus (HAV) in Northeast India (NEI) who are ethnically distinct, tribal dominated and lower socio-economic status with almost no information available from NEI on these aspects. Briefly, 3 ml blood collected 324 random liver disease cases jaundice, receiving care at Central Hospital, N.F. Railway, Guwahati, Assam informed consent. patients detected HAV-IgM positive were included stratified as acute viral...
The present study aimed to evaluate the molecular epidemiology of HBV in chronic infected cases from northeast India (NEI), since scanty data are available region which has a predominant ethnically distinct tribal population. A total 523 clinically diagnosed index and 172 asymptomatic patients (based on family screening) were enrolled with informed consent. Patients stratified based serology, imaging, pathology, clinical grouped as cirrhotic cohorts. Analysis for serum DNA levels genotyping...
Jou is an integral part of the socio-cultural life Boros. The Boro has old age tradition preparing from fermented cooked rice (jumai) with locally prepared yeast cake called Amao. traditionally used in marriage, worship and all social occasions it three kinds Jou- bidwi, finai gwran (distilled alcohol jumai). Amao seven plants species- Oryza sativa L., Scoparia dulcis Musa paradisiaca, Artocarpus heterophyllus Lamk., Ananas comosus (L). Merr., Clerodendron infortunetum Plumbago zeylancia L....
Abstract Background and Aim: Persistent infection with hepatitis B virus (HBV) is a major etiological risk factor for hepatocellular carcinoma (HCC). The host cellular components involved in the progression of are still unclear. In present study we aimed to evaluate Ras mediated signaling persistent HBV infection. Methods: To gain insight into role carcinogenesis evaluated functionality by mutation analysis, reverse transcription‐polymerase chain reaction, immunohistochemistry (IHC),...
The study explored the role of differential RANTES concentrations, its receptor CCR5 expression and resulting immunomodulation in pathogenesis and/or recovery from falciparum malaria. population included cases uncomplicated malaria (UC-M, N=128, enrolled on follow-up basis), severe (SM, N=25), healthy controls (N=112). Serum TNF-α levels were evaluated by ELISA. Monocyte activation profile studied flow cytometry. Differential mRNA was real-time PCR. Blood parasite count registered...
Abstract microRNAs (miRNAs) are small, noncoding RNAs which regulate eukaryotic gene expression via RNA interference pathway. Recently, miRNAs have been identified in a number of viruses with current evidence suggesting that they both virus and host. This makes viral potential targets clinical intervention, the possibility inhibiting aberrant host associated disease. In this study, computational approaches were taken to scan hepatitis E (HEV) genome for putative pre‐miRNA molecules, then...
Rheumatoid arthritis (RA) is a complex, multifactorial, systemic autoimmune disease. Reports are suggestive of the role HLA especially HLA-DRB1 alterations in RA pathogenesis. Existing data involving different geographical populations on specific locus susceptibility and severity equivocal, with no available from ethnically distinct North-east Indian population, where cases alarmingly increasing. This study aimed to evaluate association gene SNPs (rs13192471, rs660895 rs6457617) an...
Background: Gallbladder carcinoma (GBC) has been stated as an Indian disease, with the highest number of cases being reported from certain districts northeast India, which ethnically distinct population. Unfortunately there are no scientific reports on underlying molecular mechanisms associated pathogenesis disease this region. Aim: The present study evaluated role differential expression human telomerase reverse transcriptase (hTERT) in development gall bladder anomalies. Materials and...
Abstract We aimed to evaluate the significance of RANTES‐CCR5 axis and resulting immunomodulatory status in Dengue pathogenesis involving a Guwahati, India based population where cases have increased alarmingly. An CC‐chemokine receptor type 5 (CCR5) messenger RNA expression CCR5 positive cell count profile was observed cases, highest being severe cases. ligand RANTES significantly decreased inversely correlated with viremia fold change Monocytes are involved virus homing replication. Its...