A5077095556- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Click Chemistry and Applications
- Metal complexes synthesis and properties
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- DNA and Nucleic Acid Chemistry
- Ferrocene Chemistry and Applications
- Molecular spectroscopy and chirality
- Luminescence and Fluorescent Materials
- Free Radicals and Antioxidants
- Nanoplatforms for cancer theranostics
- Biochemical effects in animals
- Lanthanide and Transition Metal Complexes
- Nanocluster Synthesis and Applications
- Drug Transport and Resistance Mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
- Crystal structures of chemical compounds
- Radical Photochemical Reactions
- Monoclonal and Polyclonal Antibodies Research
Trinity College Dublin
2016-2023
University College Dublin
2016-2020
22q11 Ireland
2016-2020
Université Libre de Bruxelles
2015-2017
Photochemistry Center
2017
Leefmilieu Brussel
2017
Laboratoire de Chimie Organique
2015
Université Grenoble Alpes
2014
Département de Chimie Moléculaire
2014
Centre National de la Recherche Scientifique
2014
Biological investigation of a new Tröger's base–Ru(<sc>ii</sc>)–curcumin conjugate is described.
DNA-binding and phototoxicity of Ru(<sc>ii</sc>) complexes with ligands derived from pyrazinodipyridophenazine either <bold>phen</bold> or <bold>TAP</bold> as ancillary are reported.
A family of six Ru(II) polypyridyl complexes (1–6) which contain phenanthroline-based ligands functionalized with alkyl chains different lengths (one methyl group, 10 and 21 carbon chains) either 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ancillary have been synthesized characterized. The influence the chain length on their photophysical photochemical properties well in photobiological applications has elucidated by monitoring changes MLCT-centered absorption...
A unique V-shaped "chiral" supramolecular scaffold, N-(4-pyridyl)-4-amino-1,8-naphthalimide Tröger's base (TBNap), was synthesized in good yield from a precursor (Nap). TBNap characterized using different spectroscopic methods and the molecular structure elucidated by diffraction analysis. new p-cymene-Ru(II)-curcumin conjugate (TB-Ru-Cur) designed reacting dipyridyl donor ruthenium-curcuminato acceptor [RuCur = (p-cymene)Ru-(curcuminato)Cl] presence of silver triflate. TB-Ru-Cur isolated...
Two new water-soluble amphiphilic Ru(<sc>ii</sc>) polypyridyl complexes were synthesised and their photophysical photobiological properties evaluated; both showed a rapid cellular uptake phototoxicity against HeLa cervical cancer cells.
Two new dinuclear Ru(<sc>ii</sc>) polypyridyl complexes containing an alkyl disulphide functionalised bipyridine-based ligand and either 1,10-phenanthroline (<bold>phen</bold>) or 1,4,5,8-tetraazaphenanthrene (<bold>TAP</bold>) ligands were developed.
Ruthenium(<sc>ii</sc>) polyazaaromatic complexes have gained interest in recent decades as biomolecular tools, especially the development of new phototherapeutic agents. These light emissive Ru based on π-deficient ligands were first designed to allow a photo-induced electron transfer (PET) with guanine base DNA since their <sup>3</sup>MLCT state is highly photo-oxidizing. Later field research was extended proteins highlighting PET process tryptophan residue. This paper reports kinetics...
The conjugation of oligonucleotides with reporters is great interest for improving their intrinsic properties or endowing new ones. In this context, we report herein a procedure the bis-labelling through oxime ligation (Click-O) and copper(I)-catalyzed alkyne-azide cycloaddition (Click-H). 5'-Azido 3'-aldehyde precursors were incorporated into oligonucleotides, subsequent coupling reactions Click-O Click-H (or vice versa) successfully achieved. particular, exhaustively investigated full...