A5083449069- Stress Responses and Cortisol
- Cancer, Stress, Anesthesia, and Immune Response
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Tryptophan and brain disorders
- Luminescence and Fluorescent Materials
- Chemokine receptors and signaling
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- Electron Spin Resonance Studies
- Health, psychology, and well-being
- X-ray Diffraction in Crystallography
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Redox biology and oxidative stress
- Ancient Egypt and Archaeology
- Photochromic and Fluorescence Chemistry
- Advanced Fluorescence Microscopy Techniques
- Supramolecular Chemistry and Complexes
- Photosynthetic Processes and Mechanisms
Royal College of Surgeons in Ireland
2020-2024
Trinity College Dublin
2006-2009
Evidence suggests that noradrenaline has a tonic anti-inflammatory action in the central nervous system (CNS) via its ability to suppress microglial and astrocytic activation, inhibit production of inflammatory mediators. Consequently it is suggested may play an endogenous neuroprotective role CNS disorders where events contribute pathology. Here we demonstrate acute treatment rats with reuptake inhibitors (NRIs) desipramine atomoxetine elicited actions rat cortex following systemic...
Dual emissions at ~700 and 800 nm have been achieved from a single NIR-AZA fluorophore 1 by establishing parameters in which it can exist either its isolated molecular or aggregated states.Dual near infrared (NIR) fluorescence color lymph node (LN) mapping with was large-animal porcine model, injection site, channels nodes all detectable both 700 using preclinical open camera system.The also compatible imaging two clinical instruments for guided surgery.Methods: An hydrophilic phobic...
A structure-property study demonstrates switching from ACQ to AIE in a family of luminescent naphthalimides.
BF2-azadipyrromethenes are highly versatile fluorophores used for cellular and in vivo imaging the near-infrared far-red regions of spectrum. As yet, their use conjunction with super-resolution methodologies has not been explored. In this report, a series structurally related examined suitability stimulated emission depletion (STED) nanoscopy. The potential STED was initially evaluated using aqueous solutions as an effective predictor fluorophore suitability. For live cell both 2D 3D,...
Dual color fluorescence imaging has been achieved in the highly complex biomedical scenario of lymph node mapping. Emissions at 700 and 800 nm can be from a single fluorophore by establishing molecular aggregate forms. Fluorophore was compatible with clinical systems for guided surgery no toxicity observed high dosage testing.
<p>Dual color fluorescence imaging has been achieved in the highly complex biomedical scenario of lymph node mapping. Emissions at 700 and 800 nm can be from a single fluorophore by establishing molecular aggregate forms. Fluorophore was compatible with clinical systems for guided surgery no toxicity observed high dosage testing.</p>
A bio-responsive nanoparticle was formed by the directed self-assembly (DSA) of a hydrophobic NIR-fluorophore with poloxamer P188. Fluorophore emission switched off when part nanoparticle, however upon stimulus induced dis-assembly on. The quenching shown to be due fluorophore hydration and aggregation within turn on response attributable disassembly embedding lipophilic environments. This exploited for temporal spatial live cell imaging measurable fluorescence seen intracellular delivery...