About
Contact & Profiles
A5076809140
Research Areas
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Viral Infections and Outbreaks Research
University of Nebraska Medical Center
2022
Treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy. However, suboptimal adherence to the existing therapy has led need for ultralong-acting antivirals. A lipophilic and hydrophobic ProTide was made by replacing alanyl isopropyl ester present in tenofovir alafenamide (TAF) with a docosyl phenyl ester, now referred as M1TFV. NM1TFV nanoformulated TAF (NTAF) nanocrystals were formulated high-pressure homogenization. single intramuscular injection NM1TFV, but not NTAF,...
10.1126/sciadv.ade9582
article
EN
cc-by-nc
Science Advances
2022-12-23
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