A5033814400- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- HIV Research and Treatment
- Adipose Tissue and Metabolism
- HIV-related health complications and treatments
- Liver physiology and pathology
- Diet, Metabolism, and Disease
- Biochemical effects in animals
- Sulfur Compounds in Biology
- Robotic Mechanisms and Dynamics
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Fatty Acid Research and Health
- Tryptophan and brain disorders
- Muscle metabolism and nutrition
- Lipid metabolism and biosynthesis
- Iterative Learning Control Systems
- Alcoholism and Thiamine Deficiency
- Phytochemicals and Antioxidant Activities
- Pancreatitis Pathology and Treatment
- Cholesterol and Lipid Metabolism
University of Nebraska Medical Center
2015-2025
Najran University
2024
VA Nebraska Western Iowa Health Care System
2014-2023
SRM Institute of Science and Technology
2021-2022
University of Nebraska at Omaha
2012-2022
Nebraska Medical Center
2016-2020
University of Nottingham
2016
Royal Derby Hospital
2016
University of Louisville
2016
University of Colorado Denver
2016
Oxidative stress has been shown to play a major role in aging and neurodegenerative disorders. Protein modification is one of the important consequences oxidative stress. In present study, we evaluated grape seed extract on memory, reactive oxygen species production, protein carbonyls (PCO), thiol status discrete regions central nervous system young aged rats. Male albino rats Wistar strain were divided into four groups: Group I--control rats, II--young treated with (100 mg/kg BW) for 30...
Binge drinking is the most common form of excessive alcohol use. Repeated episodes binge cause multiple organ injuries, including liver damage. We previously demonstrated that chronic ethanol administration causes a decline in intrahepatic ratio S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH). This impairments essential methylation reactions result alcohol-induced fatty (steatosis) and other features alcohol-associated disease (ALD). Co-treatment with betaine during feeding,...
About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-stage liver diseases potentiated by alcohol. HBV replicates in hepatocytes, but other non-parenchymal cells can sense the virus. In this study, we aimed investigate regulatory effects of macrophages on marker interferon-stimulated genes (ISGs) expressions hepatocytes. This study was performed HBV-replicating HepG2.2.15 human monocyte-derived (MDMs). We found that exposure an...
Alcohol consumption exacerbates the pathogenesis of hepatitis C virus (HCV) infection and worsens disease outcomes. The exact reasons are not clear yet, but they might be partially attributed to ability alcohol further suppress innate immunity. Innate immunity is known already decreased by HCV in liver cells.In this study, we aimed explore mechanisms how metabolism dysregulates IFNα signaling (STAT1 phosphorylation) HCV+ hepatoma cells. To end, CYP2E1+ Huh7.5 cells were infected with exposed...
Alcohol exposure worsens the course and outcomes of hepatitis C virus (HCV) infection. Activation protective antiviral genes is induced by IFN-α signaling, which altered in liver cells either HCV or ethanol exposure. However, mechanisms combined effects metabolism signaling modulation are not well elucidated. Here, we explored a possibility that potentiates HCV-mediated dysregulation via impairment methylation reactions. HCV-infected Huh7.5 CYP2E1(+) human hepatocytes were exposed to...
This review covers some important new aspects of the alcohol-induced communications between liver parenchymal and non-parenchymal cells leading to injury development. The information exchange various cell types may promote end-stage disease progression involves multiple mechanisms, such as direct cell-to-cell interactions, extracellular vesicles (EVs) or chemokines, cytokines, growth factors contained in fluids/cell culture supernatants. Here, we highlighted role EVs derived from...
Alcohol consumption exacerbates hepatitis C virus (HCV) pathogenesis and promotes disease progression, although the mechanisms are not quite clear. We have previously observed that acetaldehyde (Ach) continuously produced by acetaldehyde-generating system (AGS), temporarily enhanced HCV RNA levels, followed a decrease to normal or lower which corresponded apoptosis induction. Here, we studied whether Ach-induced caused depletion of HCV-infected cells what role apoptotic bodies (AB) play in...
In an era of improved survival due to modern antiretroviral therapy, liver disease has become a major cause morbidity and mortality, resulting in death 15–17% human immunodeficiency virus (HIV)-infected patients. Alcohol enhances HIV-mediated damage promotes the progression advanced fibrosis cirrhosis. However, mechanisms behind these events are uncertain. Here, we hypothesize that ethanol metabolism potentiates accumulation HIV hepatocytes, causing oxidative stress intensive apoptotic cell...
Treatment of chronic hepatitis B virus (HBV) requires lifelong daily therapy. However, suboptimal adherence to the existing therapy has led need for ultralong-acting antivirals. A lipophilic and hydrophobic ProTide was made by replacing alanyl isopropyl ester present in tenofovir alafenamide (TAF) with a docosyl phenyl ester, now referred as M1TFV. NM1TFV nanoformulated TAF (NTAF) nanocrystals were formulated high-pressure homogenization. single intramuscular injection NM1TFV, but not NTAF,...