A5067032328- Receptor Mechanisms and Signaling
- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Advanced Biosensing Techniques and Applications
University of Pennsylvania
2022-2025
California University of Pennsylvania
2024-2025
The opioid crisis is a catastrophic health emergency catalyzed by the misuse of opioids that target and activate mu receptor. Many traditional radioligands used to study receptor are often tightly regulated owing their abuse respiratory depression potential. Of those not regulated, lack subtype selectivity can cause confounding in interpreting results. In present study, we sought design characterize library 24 antagonist ligands for Ligands were evaluated binding affinity, intrinsic...
M503-1619 was identified as a promising ligand for positron emission tomography (PET) imaging of α-synuclein (α-Syn) pathology in Parkinson’s disease (PD). An Exemplar binding site 9 (residues GLY-86, ILE-88,...
The intrinsic photochemistry of the isoxazole, a common heterocycle in medicinal chemistry, can be applied to offer an alternative existing strategies using more perturbing, extrinsic photo-crosslinkers. utility isoxazole photo-crosslinking is demonstrated wide range biologically relevant experiments, including proteomics workflows.
Abstract The opioid crisis is a catastrophic health emergency catalyzed by the misuse of opioids that target and activate mu receptor. Traditional radioligands used to study receptor are often tightly regulated owing their abuse respiratory depression potential. In present study, we sought design characterize library 24 non-agonist ligands for Ligands were evaluated binding affinity, intrinsic activity, predicted blood-brain barrier permeability. Several demonstrated single-digit nM affinity...