A5101627148- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
Hope Center for Neurological Disorders
2022-2024
Washington University in St. Louis
2022-2023
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation alpha-synuclein (Asyn) fibrils in bodies neurites. Here we develop validate a method to amplify Asyn extracted from LBD postmortem tissue samples use solid state nuclear magnetic resonance (SSNMR) studies determine atomic resolution structure. Amplified comprise mixture single protofilament two with very low twist. fold highly similar determined by recent cryo-electron microscopy study...
Parkinson disease (PD) is defined by the accumulation of misfolded α-synuclein (α-syn) in Lewy bodies and neurites. It affects multiple cortical subcortical neuronal populations. The majority people with PD develop dementia, which associated neocortex referred to as body dementia (LBD). Other neuropathologic changes, including amyloid β (Aβ) tau accumulation, occur some LBD cases. We sought quantify α-syn, Aβ, neocortical, limbic, basal ganglia regions.
M503-1619 was identified as a promising ligand for positron emission tomography (PET) imaging of α-synuclein (α-Syn) pathology in Parkinson’s disease (PD). An Exemplar binding site 9 (residues GLY-86, ILE-88,...
Abnormal α-synuclein (α-syn) aggregation characterizes α-synucleinopathies, including Parkinson's disease (PD) and multiple system atrophy (MSA). However, no suitable positron emission tomography (PET) radiotracer for imaging α-syn in PD MSA exists currently. Our structure–activity relationship studies identified 4-methoxy-N-(4-(3-(pyridin-2-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)phenyl)benzamide (4i) as a PET candidate α-syn. In vitro assays revealed high binding of 4i to recombinant fibrils...
The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation alpha-synuclein (Asyn) fibrils in bodies neurites. We developed validated a novel method to amplify Asyn extracted from LBD postmortem tissue samples used solid state nuclear magnetic resonance (SSNMR) studies determine atomic resolution structure. Amplified comprise two protofilaments with pseudo-2