A5101953534- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Lymphatic System and Diseases
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Head and Neck Cancer Studies
- Monoclonal and Polyclonal Antibodies Research
- Neuroscience and Neural Engineering
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Salivary Gland Tumors Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Breast Cancer Treatment Studies
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Oral and Maxillofacial Pathology
- Pituitary Gland Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Adrenal and Paraganglionic Tumors
- Skin and Cellular Biology Research
Osaka International Cancer Institute
2018-2022
The University of Tokyo
2012-2021
National Center for Global Health and Medicine
2012-2021
Kindai University Hospital
2021
La Jolla Institute for Immunology
2016-2020
Health Foundation
2017
German Centre for Cardiovascular Research
2016
Ludwig-Maximilians-Universität München
2016
Inflammation Research Foundation
2015
University of Tokyo Hospital
2015
Background: CD4 + T cells play an important role in atherosclerosis, but their antigen specificity is poorly understood. Immunization with apolipoprotein B (ApoB, core protein of low density lipoprotein) known to be atheroprotective animal models. Here, we report on a human APOB peptide, p18, that sequence-identical mouse ApoB and binds both major histocompatibility complex class II molecules. Methods: We constructed p18 tetramers detect APOB-specific assayed phenotype by flow cytometry...
Throughout the inflammatory response that accompanies atherosclerosis, autoreactive CD4+ T-helper cells accumulate in atherosclerotic plaque. Apolipoprotein B100 (apoB), core protein of low-density lipoprotein, is an autoantigen drives generation pathogenic type 1 (TH1) with proinflammatory cytokine secretion. Clinical data suggest existence apoB-specific T atheroprotective, regulatory cell (Treg) phenotype healthy individuals. Yet, function apoB-reactive Tregs and their relationship TH1...
Rationale: CD4 T cells are involved in the pathogenesis of atherosclerosis, but atherosclerosis-specific have not been described. Moreover, chemokine(s) that regulates T-cell trafficking to atherosclerotic lesions is also unknown. Objective: In Apoe −/− mice with mature (5 months high fat diet), we find most aortic express CCR5 and interferon-γ a unique combination cell surface markers (CD4 + CD25 − CD44 hi CD62L lo ) transcription factors (FoxP3 T-bet ). We call these CCR5Teff. investigated...
// Takayuki Kimura 1, 2 , Makoto Sugaya Tomonori Oka Andrew Blauvelt 3 Hitoshi Okochi Shinichi Sato 1 Department of Dermatology, Faculty Medicine, University Tokyo, Japan Regenerative Research Institute, National Center for Global Health and Oregon Medical Center, Portland, Oregan, USA Correspondence to: Sugaya, e-mail: sugayam-der@h.u-tokyo.ac.jp Keywords: lymphatics, lymphedema, tumor immunity, cytotoxic T cells Received: March 18, 2015 Accepted: May 11,...
Although immunization with major histocompatibility complex (MHC) class II-restricted apolipoprotein B (ApoB) peptides has been shown to be atheroprotective, the mechanism is unclear. Here, we investigated CD4+ T cell populations in immunized atherosclerotic mice. Peptides (16-mers) from mouse ApoB, core protein of low-density lipoprotein (LDL), were screened for binding I-Ab by computer prediction and confirmed radiolabeled peptide competition. Three new peptides, P101 (FGKQGFFPDSVNKALY,...
Skin wound healing is an interactive process involving soluble mediators, ECM, resident cells, and infiltrating cells. Little known about in the presence of lymphedema. In this study, we investigated using kCYC⁺/⁻ mice, which demonstrate severe lymphatic dysfunction. Wound was delayed significantly mice when compared with WT mice. wounded skin mast cell numbers were increased whereas macrophage decreased. Moreover, IL-10 expression by cells increased, bFGF, mainly produced macrophages,...
Abstract Vaccination with MHC‐II‐restricted peptides from Apolipoprotein B (ApoB) complete and incomplete Freund's adjuvant (CFA/IFA) is known to protect mice atherosclerosis. This vaccination induces antigen‐specific IgG1 IgG2c antibody responses a robust CD4 T cell response in lymph nodes. However, CFA/IFA cannot be used humans. To find clinically applicable adjuvant, we tested the effect of vaccinating Apoe ‐deficient ApoB peptide P6 (TGAYSNASSTESASY). In broad screening experiment,...
Previous studies of guselkumab have demonstrated clinical benefits in patients with plaque-type psoriasis, generalized pustular erythrodermic psoriasis and palmoplantar pustulosis (PPP).The aim this exploratory analysis a double-blind, multicenter, placebo-controlled, phase 3 study Japanese PPP was to evaluate the efficacy subset pustulotic arthro-osteitis (PAO).Patients were randomized receive 100 or 200 mg at weeks 0, 4, 12 every 8 weeks, placebo cross-over week 16 (placebo group)....
Abstract Purpose This study evaluated treatment patterns and clinical outcomes among patients with metastatic triple-negative breast cancer (mTNBC) in real-world settings Japan. Methods The patterns, time to next or death (TTNTD), discontinuation, adverse events of interest, medical costs treating mTNBC first-, second-, third-line were investigated using data meeting the inclusion criteria between January 2017 March 2022 a Japanese claims database. regimens for defined according Breast...
Abstract Background: Eribulin mesylate (eribulin), a non-taxane microtubule dynamics inhibitor, has unexpectedly shown greater effects on overall survival compared to progression-free in late stage metastatic breast cancer patients the clinic. This finding suggests that eribulin may have additional, previously-unrecognized anti-tumor mechanisms beyond its established antimitotic activity. To investigate this possibility, eribulin's balance of EMT/ MET MX-1 human cells were investigated....
要介護高齢者の直接死因は肺炎が最も多いと言われており，高齢者の肺炎の約半数が誤嚥性肺炎であると推測されている．この肺炎を予防するために介護予防に「口腔機能向上」が導入された．本研究では，某県の介護保険関連施設337施設を対象にアンケート調査を行い，279施設から回答を得た．調査内容の一部である口腔ケアに関する質問項目について，施設の形態別，研修参加および歯科医師への相談体制の有無別に検討した．施設の形態を問わず，口腔ケアの必要性に対する意識は高いものの，実際に行うには自信をもてない職員が多いことが明らかとなった．また，口腔ケアに関する研修会への参加や，歯科医師への相談体制を整えることが自信をもって口腔ケアを行うことにつながることも示唆された．以上のことから，今後は口腔ケアに関する教育や歯科医師との連携などの普及に取り組む必要があると考えられた．
CheckMate 141試験において，再発・転移性頭頸部扁平上皮癌に対してニボルマブは医師選択治療と比較して全生存期間（OS）を有意に延長することが示された。しかし，同試験には扁平上皮癌以外の組織型および上咽頭癌は含まれていない。今回我々は，当院でニボルマブを投与した頭頸部癌28例について後方視的に検討した。本検討では，非扁平上皮癌が2例，上咽頭癌が9例含まれていた。全症例の無増悪生存期間（PFS）中央値4.3ヶ月，OS中央値は未到達であった。測定可能病変を有する24例の検討で，奏効率は16.7％，病勢コントロール率は54.2％であった。免疫関連有害事象（irAE）は46.4％で発症し，Grade 3のirAEは7.1％で発症した。irAE発症群は未発症群と比較して有意なPFSの延長が示された。本検討では非扁平上皮癌や上咽頭癌の症例が含まれていたが，ニボルマブの有効性が示されていた。
66歳，女性。初診の1ヵ月前，外陰部に紅色腫瘤を自覚した。生検の結果，不整形で大小不同な短紡錘形の核を持ったN/C比の高い細胞が増殖しており，免疫染色にてHMB45陽性，Melan－A陽性，S100一部陽性であり，悪性黒色腫と診断した。CT，PETで転移はみられず，切除およびセンチネルリンパ節生検を施行した。切除断端が陽性であり，その後腫瘍の完全切除までにさらに2回の手術を要した。無色素性悪性黒色腫は紅色を呈することが多く，また女性の外陰部にできた際には粘膜が淡紅色であるため，他部位よりも一層腫瘍の進展範囲を把握するのが困難である。また外陰部は尿道，肛門，女性の場合は膣も近接しており，腫瘍が進展した後では手術侵襲も大きくなることが多い。外陰部の紅色腫瘤をみた際に，悪性黒色腫も鑑別とし，早期発見，早期治療を行っていく必要がある。
Background: Immune cells, including T figure prominently in atherosclerosis. cells the atherosclerotic plaque have been proposed to recognize self-antigen, such as peptides derived from Apolipoprotein B-100. However, antigen-specific not identified Here, we aimed establish and optimize a novel MHC-II multimer based assay detect isolate specifically recognizing ApoB-100 amino residues 978-993. We previously shown that vaccination with this peptide protects mice Materials Methods: screened...