Graphene oxide (GO) nanoparticles have been developed for a variety of biomedical applications as number different therapeutic modalities may be added onto them. Here, we report the development and testing such multifunctional GO nanoparticle platform that contains grafted cell-targeting functionality, active pharmaceutical ingredients, particulates enable use magnetothermal therapy. Specifically, demonstrate ability to covalently attach hyaluronic acid (HA) GO, resultant nanoparticulates...

The study presented in this work consists of two parts: first part is the synthesis Graphene oxide-Fe3O4 nanocomposites by a mechanochemical method which, mechanical process that likely to yield extremely heterogeneous particles. second includes on efficacy these kill cancerous cells. Iron powder, ball milled along with graphene oxide toluene medium, underwent controlled oxidation process. Different phases GO-Fe3O4 were obtained based composition used for milling. As synthesized...

Magnetic nanomotors with integrated theranostic capabilities can revolutionize biomedicine of the future. Typically, these contain ferromagnetic materials, such that small magnetic fields be used to maneuver and localize them in fluidic or gel-like environments. Motors large permanent moments tend agglomerate, which limits scalability this otherwise promising technology. Here, we demonstrate application a microwave-synthesized ferrite layer reduce agglomeration helical by an order magnitude,...

This book is based on the new theories and technologies developed recently. It covers theoretical background, experimental techniques a few biomedical applications. The historical overview provided in beginning gives feel for advancement of technologies. rare that one can get all information single book.

Abstract The development of scaffolds for neural tissue engineering application requires an understanding cell adhesion, proliferation, and migration neuronal cells. Considering the potential carbon as scaffold materials lack compatibility amorphous with cells, carbon‐based in forms films continuous electrospun nanofibers having average diameter ∼200 nm are being investigated or without ultraviolet (UV) oxy‐plasma (OP) treatments cytocompatibility property using mouse Neuroblastoma (N2a) rat...

Abstract Background The treatment of non‐melanoma skin cancer and deadliest malignant melanoma are the fifth ninth most expensive treatments in Medicare, respectively. Moreover, recurrence after currently available therapies, that is, surgery or radiotherapy, reduces patient's life expectancy. Aims In view this, we fabricated magnetic nanofibrous mat‐based bandage to treat non‐invasively using an external alternating current (AC) field induced hyperthermia. Methods Fe 3 O 4 nanoparticles...

The robust nature of a biocompatible fluorescent probe is demonstrated, by its detection Fe3+ even after repeated rounds quenching (reversibility) acetate in real human blood samples and cells vitro. Significantly trace levels ions up to 8.2 nM could be detected, remaining unaffected the existence various other metal ions. obtained results are validated AAS ICP-OES methods. A portable test strip also fabricated for quick on field Fe3+. As iron ubiquitous plays prominent role biological...

Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems studied their candidacy for cancer treatment. The polycaprolactone-Fe3 O4 based MAST fibers were using electrospinning technique. These contained carbogenic quantum dots as a tracking agent doxorubicin hydrochloride anticancer drug. Additionally, able deliver drug heat energy simultaneously kill...

Abstract Surface energy plays a major role in prokaryotic and eukaryotic cell interactions with biomedical devices. In the present study, poly(ε‐caprolactone)‐ x Fe 3 O 4 nanoparticles (PCL‐ FO NPs; = 0, 10, 20, 30, 40, 60 wt% concentration PCL) composite thin films were developed for skin tissue regeneration. The surface properties terms of roughness, energy, wettability altered incorporation NPs. These show antimicrobial cyto‐compatibility NIH 3T3 mouse embryonic fibroblast cells. porosity...

Metal-induced allergic contact dermatitis, particularly nickel, affects over 10% of the general population. Herein, chitosan-glycerol gel as protective barrier formulation was synthesized by neutralization reaction with an aim to reduce metal-ion diffusion into skin prevent allergy. Active functional groups in were able capture allergenic metal ions present artificial sweat solution. The efficacy against nickel-ion penetration evaluated ex vivo using pig skin. We found that percutaneous...

The poor penetration of anti-fungal agents into the cornea through intact epithelium layer makes it difficult to treat acute fungal corneal infections. Herein, we developed Amphotret (amphotericin B) antifungal drug contained polycaprolactone-Fe3O4 (PCL-FO) magnetic nanofibers (MNFs) using electrospinning technique. These MNFs generate heat in presence AC field (AMF) and release upon heating. were compatible with human mesenchymal stem cells (hMSCs) HeLa cells, which exhibited unaltered...

Although several advances have been made in the field of medicine during last few decades, yet targeted delivery biomolecules is still a significant challenge. Thus, present study illustrates fabrication dual nature magneto-conducting Fe3 O4 -SU8 derived carbon-based Janus microbots that could deliver efficiently inside cells. These microsystems possess properties, is, half part magneto-conducting, and another only conducting for sufficing therapeutic payloads under electromagnetic...