A5078654090- Plasma Applications and Diagnostics
- PARP inhibition in cancer therapy
- Plasma Diagnostics and Applications
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- Cannabis and Cannabinoid Research
- Mass Spectrometry Techniques and Applications
- Plant Genetic and Mutation Studies
- Nanoparticles: synthesis and applications
- Microbial Inactivation Methods
- Calcium signaling and nucleotide metabolism
- Gas Sensing Nanomaterials and Sensors
- Combustion and Detonation Processes
- Mercury impact and mitigation studies
- Electrospun Nanofibers in Biomedical Applications
- CRISPR and Genetic Engineering
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Neuroblastoma Research and Treatments
- Cell death mechanisms and regulation
- Microplastics and Plastic Pollution
- Brain Metastases and Treatment
- Toxin Mechanisms and Immunotoxins
Bhabha Atomic Research Centre
2016-2025
Homi Bhabha National Institute
2022-2025
Indian Institute of Science Bangalore
2016
Abstract Synthetic lethality in homologous recombination (HR)‐deficient cancers caused by Poly (ADP‐ribose) polymerase inhibitors (PARPi) has been classically attributed to its role DNA repair. The mode of action PARPi and resistance thereof are now believed be predominantly replication associated. Therefore, effective combinatorial approaches targeting fork processing along with HR‐downregulation target HR‐proficient possibly PARPi‐resistant tumors warranted. Stilbenes a privileged class...
Abstract Background Poly(ADP-ribose) polymerase inhibitors (PARPi) target tumours defective in homologous recombination (HR). Most BRCA-wild-type (WT) HR-proficient breast cancers are intrinsically resistant to PARP inhibitors, e.g., talazoparib. We evaluated the role of autophagy this de novo resistance and determined underlying mechanism overcome this. Methods Autophagosome formation autophagic flux were assessed by evaluating endogenous LC3-II levels ectopic expression EGFP-LC3...
// Bhaskar Saha 1, 2, * , Birija Sankar Patro 3, 4, Mrunesh Koli 3 Ganesh Pai Jharna Ray 2 Sandip K. Bandyopadhyay 1 and Subrata Chattopadhyay 4 Vijaygarh Jyotish College, Jadavpur, Kolkata 700 032, India S. N. Pradhan Centre for Neuroscience, Ballygunge Science University of Calcutta, 019, Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085, Homi National Institute, Training School Complex, Anushakti Nagar, 400094, These authors have contributed equally to this work...
A newly developed excitation frequency-controlled cold atmospheric pressure plasma (EFCAP) jet produces a variable density of reactive oxygen and nitrogen species (RONS) by merely modifying the frequency. The composition gas temperature can both be controlled changing because different applications may require distinct properties. This study examines impact addition on electrical parameters emission characteristics argon generated at 15 kHz. was conducted using mixture Ar (as working gas) N...
Abstract Surface energy plays a major role in prokaryotic and eukaryotic cell interactions with biomedical devices. In the present study, poly(ε‐caprolactone)‐ x Fe 3 O 4 nanoparticles (PCL‐ FO NPs; = 0, 10, 20, 30, 40, 60 wt% concentration PCL) composite thin films were developed for skin tissue regeneration. The surface properties terms of roughness, energy, wettability altered incorporation NPs. These show antimicrobial cyto‐compatibility NIH 3T3 mouse embryonic fibroblast cells. porosity...
Abstract Recently developed excitation frequency‐controlled cold atmospheric pressure plasma has shown its efficacy in producing tunable effects with different frequencies terms of reactive species generation and cancer cell death. This study investigates the electron number density produced at 11 kHz from stark broadened Hα line, discharge characteristics through simultaneous recording voltage‐current signals, high‐speed images zone. Malignant breast cells (MCF‐7) nonmalignant (MCF‐10A)...
<title>Abstract</title> Purpose Novel, alternative and combinatorial approaches to combat cancers with minimal side effects is the need of hour, owing significant therapy-associated adverse effects. Natural molecule curcumin has shown have anticancer action in lung cancers, a major cause mortality world over. However, usage limited by its poor bioavailability. High voltage microsecond pulse electric field (HV-µsPEF) therapy an emerging option cancer which can be used as effective adjuvant...