A5024310309- Multiple Myeloma Research and Treatments
- Stress Responses and Cortisol
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Healthcare Policy and Management
- Heart Rate Variability and Autonomic Control
- Child and Adolescent Psychosocial and Emotional Development
- Cardiac Health and Mental Health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Eating Disorders and Behaviors
- Hormonal and reproductive studies
- Mental Health Research Topics
- Resilience and Mental Health
- Lipoproteins and Cardiovascular Health
- Exercise and Physiological Responses
- Psychology, Coaching, and Therapy
- Herpesvirus Infections and Treatments
- Sports Performance and Training
- HIV/AIDS Impact and Responses
- Public Health Policies and Education
- Immunotherapy and Immune Responses
- Food Security and Health in Diverse Populations
- School Health and Nursing Education
- Diabetes Management and Research
- Thermoregulation and physiological responses
University of Birmingham
2014-2024
Freeman Hospital
2024
University College London
2019
Institute of Infection and Immunity
2015
Birmingham City University
2013-2014
Indiana University – Purdue University Indianapolis
2012
University of Iowa
2012
University of Nottingham
2012
University of Bristol
2012
Versus Arthritis
2012
Abstract Background Detecting antibody responses during and after SARS-CoV-2 infection is essential in determining the seroepidemiology of virus potential role disease. Scalable, sensitive specific serological assays are to this process. The detection hospitalized patients with severe disease has proven straightforward; detecting subjects mild asymptomatic infections less reliable. We hypothesized that suboptimal sensitivity compartmentalization response may contribute effect. Methods...
Although perceiving one's social ties as sources of ambivalence has been linked to negative health outcomes, the more specific contexts by which such relationships influence remain less studied. We thus examined if perceived spousal relationship quality in three theoretically important (i.e., support, capitalization, everyday life) predicted inflammation.Ninety-four married couples completed measures positivity and negativity contexts. These scores were used derive an index whereby...
We measured immunosuppression at myeloma diagnosis and assessed the impact on survival in 5826 UK trial patients. Polyclonal immunoglobulin levels were below normal 85% of patients above only 0.4% cases for IgA, 0.2% IgM no IgG. Immunoparesis had a greater recent trials: median overall (OS) was up to 3 years longer without immunoparesis compared old trials, less than 1 year longer. Median progression-free (PFS) 39%, 36% 57% with IgG, IgA levels, respectively. The depth suppression, but not...
Detecting antibody responses during and after SARS-CoV-2 infection is essential in determining the seroepidemiology of virus potential role disease. Scalable, sensitive specific serological assays are to this process. The detection hospitalized patients with severe disease has proven relatively straightforward; detecting subjects mild asymptomatic infections less reliable. We hypothesized that suboptimal sensitivity compartmentalization response may contribute effect. systematically...
The present study examined the relationship between habitual physical activity, life events stress, diurnal rhythms of cortisol and DHEA, cortisol:dehydroepiandrosterone (DHEA) ratio in older adults. Thirty-six participants aged ≥ 65 reported their indicated if a particular event happened to them past year (stress incidence) how stressful they perceived be severity). Older adults with higher stress severity demonstrated significantly cortisol:DHEA ratio. Individuals incidence scores who did...
BACKGROUND/STUDY CONTEXT: The cortisol diurnal rhythm has previously been examined in relation to age and health behaviors. However, less is known about the relationship between multiple behaviors context of aging, where it possible that impact on varies as a function age. This study compared awakening response young versus older adults
Abstract Background: Serum free light chains (FLC) are sensitive biomarkers used for the diagnosis and management of plasma cell dyscrasias, such as multiple myeloma (MM), central to clinical screening algorithms therapy response criteria. We have developed a portable, near-patient, lateral-flow test (Seralite Methods: Assay interference, imprecision, lot-to-lot variability, linearity, utility competitive-inhibition design elimination antigen-excess (‘hook effect’) were assessed. Reference...
Summary This study aims to guide the integration of serum free light chain ( sFLC ) tests into clinical practice, including a new rapid test (Seralite ® ). Blood and urine analysis from 5573 newly diagnosed myeloma patients identified 576 only LCO 60 non‐secretory NS cases. Serum was tested by Freelite Seralite at diagnosis, maximum response relapse. 20% had FLC levels below that recommended for measuring but >97% these adequate (oligosecretory). The ≥100 mg/l confirmed equivalent...
Salivary antibodies may act as non-invasive marker of systemic immunity enabling assessment vaccination and protection against bacterial infections.To assess if levels anti-pneumococcal (Pn) in saliva reflect concentrations serum determine whether can accurately identify protective serum.IgG, IgA IgM antibody paired samples were measured 12 Pn polysaccharide antigens 72 healthy adults.Antibody correlated positively with across immunoglobulin classes, most strongly for IgA. Individuals who...
Summary Multiple myeloma (MM) and anti‐MM therapy cause profound immunosuppression, leaving patients vulnerable to coronavirus disease 2019 (COVID‐19) other infections. We investigated anti‐severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) antibodies longitudinally in ultra‐high‐risk with MM receiving risk‐adapted, intensive anti‐CD38 combined the Myeloma UK (MUK) nine trial. Despite continuous therapy, seroconversion was achieved all patients, but required a greater number of...