A5034739948- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Bacteriophages and microbial interactions
- SARS-CoV-2 detection and testing
- RNA and protein synthesis mechanisms
- Antimicrobial agents and applications
- Infection Control and Ventilation
- Infection Control in Healthcare
- Immune responses and vaccinations
- melanin and skin pigmentation
- Mast cells and histamine
- Thermal Regulation in Medicine
- Indoor Air Quality and Microbial Exposure
- Advancements in Transdermal Drug Delivery
- Respiratory viral infections research
- Biomarkers in Disease Mechanisms
- Microplastics and Plastic Pollution
- COVID-19 Impact on Reproduction
- Marriage and Sexual Relationships
- Reproductive System and Pregnancy
- Nanoparticles: synthesis and applications
- COVID-19 epidemiological studies
- Dermatological and COVID-19 studies
- PARP inhibition in cancer therapy
University of Birmingham
2021-2024
Institute of Immunology
2023
Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity efficacy of SARS-CoV-2 vaccines patients with antibody deficiency is poorly understood.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose treat SARS-CoV-2 infections, we established screen measure the dimerization angiotensin-converting enzyme 2 (ACE2), primary receptor for virus. This identified fenofibric acid, active metabolite fenofibrate. Fenofibric acid also destabilized receptor-binding domain (RBD) viral spike protein inhibited RBD binding ACE2...
Abstract The COVID-19 pandemic has demonstrated the real need for mechanisms to control spread of airborne respiratory pathogens. Thus, preventing disease from pathogens come forefront public consciousness. This brought an increasing demand novel technologies prioritise clean air. In this study we report on efficacy biocide treated filters and their antimicrobial activity against bacteria, fungi viruses. reported here are shown kill pathogens, such as Candida albicans , Escherichia coli MRSA...
Thrombotic complications and vasculopathy have been extensively associated with severe COVID-19 infection; however, the mechanisms inducing endotheliitis disruption of endothelial integrity in microcirculation are poorly understood. We hypothesized that within vessel wall, pericytes preferentially take up viral particles mediate subsequent loss vascular integrity.
Background Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third vaccinations have been deployed enhance their humoral cellular immunity. Objectives To determine the immunogenicity of third immunisation in a heterogeneous cohort patients deficiency. Methods Participants enrolled COV-AD study were sampled before after dose. Serological determined using ELISA, live-virus...
Background The systemic inflammatory response post-SARS-CoV-2 infection increases pro-inflammatory cytokine production, multi-organ damage, and mortality rates. Mast cells (MC) modulate thrombo-inflammatory disease progression ( e.g. , deep vein thrombosis) the post-infection. Objective To enhance our understanding of contribution MC their proteases in SARS-CoV-2 pathogenesis disease, which might help to identify novel therapeutic targets. Methods chymase (CMA1), carboxypeptidase A3 (CPA3),...
In the present work, we developed an effective antimicrobial surface film based on sustainable microfibrillated cellulose. The resulting porous cellulose thin is barely noticeable to human eyes due its submicrometer thickness, of which coverage, porosity, and microstructure can be modulated by formulations coating process. Using goniometers a quartz crystal microbalance, observed threefold reduction in water contact angles accelerated evaporation kinetics (more than 50% faster that flat...
Hand hygiene is considered to be the key factor in controlling and preventing infection, either hospital care settings or community. Alcohol-based hand sanitizers are commonly used due their rapid action broad spectrum of microbicidal activity, offering protection against bacteria viruses. However, frequent administration during COVID-19 pandemic was associated with serious hazards, such as skin toxicity, including irritation, dermatitis, dryness cracking, along peeling redness itching,...
Summary Multiple myeloma (MM) and anti‐MM therapy cause profound immunosuppression, leaving patients vulnerable to coronavirus disease 2019 (COVID‐19) other infections. We investigated anti‐severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) antibodies longitudinally in ultra‐high‐risk with MM receiving risk‐adapted, intensive anti‐CD38 combined the Myeloma UK (MUK) nine trial. Despite continuous therapy, seroconversion was achieved all patients, but required a greater number of...
Abstract The untranslated regions (UTRs) of viral genomes contain a variety conserved yet dynamic structures crucial for replication, providing drug targets the development broad spectrum anti‐virals. We combine in vitro RNA analysis with molecular dynamics simulations to build first 3D models structure and key 5′ UTR SARS‐CoV‐2 genome. Furthermore, we determine binding metallo‐supramolecular helicates (cylinders) this structure. These nano‐size agents are uniquely able thread through...
The importance of salivary SARS-CoV-2 antibodies, following infection and vaccination, has not been fully established. 875 healthcare workers were sampled during the first wave in 2020 66 longitudinally response to Pfizer BioNTech 162b2 vaccination. We measured total IgGAM individual IgG, IgA IgM antibodies. seroprevalence was 39.9%; however, only 34.1% seropositive individuals also had Infection generated serum IgG antibodies 51.4% individuals. In contrast, antibody responses dominated by...
Abstract The SARS-CoV-2 pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose treat infections, we established screen measure dimerization ACE2, the primary receptor for virus. This identified fenofibric acid, active metabolite fenofibrate. Fenofibric acid also destabilized binding domain (RBD) viral spike protein inhibited RBD ACE2 in ELISA whole cell assays. Fenofibrate were tested by two independent laboratories measuring infection...
Abstract Background Vaccination prevents severe morbidity and mortality from COVID-19 in the general population. The immunogenicity efficacy of SARS-CoV-2 vaccines patients with antibody deficiency is poorly understood. Objectives COVID (COV-AD) a multi-site United Kingdom study that aims to determine immune response infection vaccination primary or secondary deficiency, population suffers recurrent does not respond well vaccination. Methods Individuals on immunoglobulin replacement therapy...
Abstract Microbial contamination of plastic surfaces is a significant source hospital‐acquired infections. To produce antimicrobial surfaces, chlorhexidine was attached to nitrided acrylonitrile butadiene styrene (ABS). The uniformity distribution on the revealed by time‐of‐flight secondary ion mass spectrometry (TOF‐SIMS) imaging. Its efficacy established against model pathogenic Gram‐positive and Gram‐negative bacteria, fungi, viruses. stability bonded evaluated via leaching test. rapidly...
The untranslated regions (UTRs) of viral genomes contain a variety conserved yet dynamic structures crucial for replication, providing drug targets the development broad spectrum anti-virals. We combine in vitro RNA analysis with molecular dynamics simulations to build first 3D models structure and key 5' UTR SARS-CoV-2 genome. Furthermore, we determine binding metallo-supramolecular helicates (cylinders) this structure. These nano-size agents are uniquely able thread through junctions...
ABSTRACT Diseases caused by SARS-CoV-2 and Mycobacterium tuberculosis ( M.tb ) represent two public health emergencies. In severe disease, both pathogens may share a biological niche in the lower respiratory tract. There is significant potential for infections to be co-present within individuals enhance or moderate respective outcomes of either infection. Here, we investigated how whole blood samples, as well CD4+ CD8+ T cells, from hospitalised with acute COVID-19 disease respond...
Abstract Background Patients with primary and secondary antibody deficiency are vulnerable to COVID-19 demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third vaccinations have been deployed enhance their humoral cellular immunity. Objectives To determine the immunogenicity of third immunisation in a heterogeneous cohort patients deficiency. Methods Participants enrolled COV-AD study were sampled before after dose. Serological determined using ELISA,...
Abstract The engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells and accordingly blocking this interaction major determinant efficacy monoclonal antibody therapeutics vaccine-elicited serum antibodies. emergence variants necessitates development adaptable assays that can be applied assess effectiveness therapeutics. Through testing range recombinant proteins, we have developed cell based, ACE2/spike binding assay characterises anti-spike...
Summary COVID-19 placentitis, a rare complication of maternal SARS-CoV-2 infection, only shows detectable virus in the placenta subset cases. We provide deep multi-omic spatial characterisation placentitis from obstetrically complicated infection. found that infected placentas have distinct transcriptional and immunopathological signature. This signature overlaps with virus-negative cases supporting common viral aetiology. An inverse correlation between load disease duration suggests...
Marriage and traditional morals have changed drastically for the Adioukrou of Ivory Coast in past forty years. Many are concerned by breakdown family structure. While it is typical that rapid culture change threatens stability societies, one must ask why biblical teaching on marriage morality has not filled void this group identified itself as Christian over seventy This paper a diachronic study which traces significant factors led to current state affairs. The final section recommends plan...
Introduction The engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction major determinant efficacy monoclonal antibody therapeutics and vaccine elicited serum antibodies. emergence variants has necessitated development adaptable assays that can be applied assess effectiveness antibody-based therapeutics. Methods Through testing range recombinant proteins, we have developed cell-based, ACE2/spike assay...