A5089281384- Asthma and respiratory diseases
- Pharmaceutical Practices and Patient Outcomes
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medication Adherence and Compliance
- Diabetes Management and Education
- Health Sciences Research and Education
- Allergic Rhinitis and Sensitization
- Ion channel regulation and function
- Health Systems, Economic Evaluations, Quality of Life
- Neuropeptides and Animal Physiology
- Mast cells and histamine
- Interprofessional Education and Collaboration
- Patient-Provider Communication in Healthcare
- Nitric Oxide and Endothelin Effects
- Neonatal Respiratory Health Research
- Health Policy Implementation Science
- Patient Satisfaction in Healthcare
- Health, psychology, and well-being
- Sleep and related disorders
- Pediatric health and respiratory diseases
- Health Literacy and Information Accessibility
- Respiratory Support and Mechanisms
Woolcock Institute of Medical Research
2015-2024
Sydney South West Area Health Service
2017-2023
The University of Sydney
2011-2021
Sydney Local Health District
2015-2019
Respiratory Clinical Trials
2001-2012
University of Tasmania
2007
Under Armour (United States)
2004
Department of Health and Aged Care
1999
St Vincent's Hospital Sydney
1998
Middlesex Hospital
1990
Despite national disease management plans, optimal asthma remains a challenge in Australia. Community pharmacists are ideally placed to implement new strategies that aim ensure care meets current standards of best practice. The impact the Pharmacy Asthma Care Program (PACP) on control was assessed using multi-site randomised intervention versus repeated measures study design.Fifty Australian pharmacies were into two groups: implemented PACP (an ongoing cycle assessment, goal setting,...
We assessed the clinical and biochemical effects in asthmatic children of fish oil supplementation a diet that increases omega-3 reduces omega-6 fatty acids. Thirty nine aged 8-12 yrs participated double-blind, randomized, controlled trial for 6 months during which they received capsules plus canola margarine (omega-3 group) or safflower sunflower (omega-6 group). Plasma acids, stimulated tumour necrosis factor alpha (TNFalpha) production, circulating eosinophil numbers lung function were...
Abstract Aim To assess the impact of a community pharmacy diabetes service model on patient outcomes in Type 2 diabetes. Methods The study utilized multisite, control vs. intervention, repeated‐measures design within four states Australia. Fifty‐six pharmacies, 28 intervention and control, were randomly selected from representative sample urban rural areas. Intervention pharmacies delivered to patients with diabetes, which comprised an ongoing cycle assessment, management review, provided at...
Claudia Dobler and colleagues argue that clear information on treatment burden in guidelines could improve decision making
The study was designed to compare in vivo responses histamine 14 patients prior thoracotomy with vitro of both parenchymal and bronchial tissue. Although a wide range responsiveness occurred vivo, as measured by the inhalation test, variation dose-response curves negligible. There no correlation between dose that resulted 20% reduction forced expiratory volume one second concentration producing 50% maximal response vitro. These findings raise possibility airway hyperresponsiveness may not...
Objective. To test the feasibility, effectiveness, and sustainability of a pharmacy asthma service in primary care. Methods. A pragmatic cluster randomized trial community pharmacies four Australian states/territories 2009. Specially trained pharmacists were to deliver an two groups, providing three versus consultations over 6 months. People with poorly controlled or no recent review included. Follow-up for 12 months after completion occurred 30% randomly selected completing patients....
The mast cell plays a pivotal role in the early asthmatic response via release of mediators, which directly influence airway smooth muscle tone. Canine tryptase has been reported to potentiate contractile canine isolated airways histamine. aim this study was investigate whether human potentiated responses bronchi. effect differed according sensitization status In lung tissue from sensitized patients (those whose bronchial contracted application any four common antigens) 90 ng.mL-1 purified...
Pharmacists are uniquely placed in the healthcare system to address critical issues asthma management community. Various programs have shown benefits of a pharmacist-led care program; however, no such previously been evaluated Australia.To measure impact specialized service provided through community pharmacies terms objective patient clinical, humanistic, and economic outcomes.A parallel controlled design, where 52 intervention patients 50 control with were recruited 2 distinct locations,...
The aim of this study was to examine the process underlying increase in responsiveness human bronchus related sensitization status by examining inflammatory cells sensitized and nonsensitized tissue. Sensitization determined tissue from 26 subjects detecting presence or absence contraction bronchial rings common Australian allergens. Serial sections (6-micron) were stained for mast cells, T lymphocytes, eosinophils. There no significant difference between total number present all locations...
An increase in the bulk of airway smooth muscle is a characteristic asthma. Much research investigating mechanisms this has focused on mediators that are mitogenic for muscle, while relatively few studies have inhibiting mitogenesis. In study we examined effects two proposed as regulators proliferation, namely heparin and prostaglandin (PG) E2, human cells culture stimulated with 1, 2.5, 5, 10% fetal bovine serum (FBS) platelet-derived growth factor AB (PDGF), 50 ng/ml. PGE2 had biphasic...