A5101501281- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical Economics and Policy
- Cancer-related Molecular Pathways
- COVID-19 Clinical Research Studies
- Ubiquitin and proteasome pathways
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Cell death mechanisms and regulation
- Colorectal Cancer Treatments and Studies
- Berberine and alkaloids research
- Antibiotic Use and Resistance
- FOXO transcription factor regulation
- Research Data Management Practices
- Long-Term Effects of COVID-19
- Organ Transplantation Techniques and Outcomes
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- 14-3-3 protein interactions
- interferon and immune responses
- Scientific Computing and Data Management
- Quinazolinone synthesis and applications
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Global Maternal and Child Health
- Thyroid Cancer Diagnosis and Treatment
Karakoram International University
2025
SUNY Upstate Medical University
2023-2024
Franklin University
2019-2024
Pakistan Institute of Medical Sciences
2021-2024
Touro College
2023-2024
Aga Khan University
2017-2023
Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology
2023
Lahore General Hospital
2021-2023
University of Haripur
2023
University College Dublin
2023
This paper reviews the worldwide growth of open‐access ( OA ) repositories, 2005 to 2012, using data collected by OpenDOAR project. Initial repository development was focused on N orth A merica, W estern E urope, and ustralasia, particularly U nited S tates, K ingdom, G ermany, ustralia, followed J apan. Since 2010, there has been in ast sia, outh astern especially T aiwan, B razil, P oland. During period, some countries, including F rance, I taly, pain, have maintained steady growth,...
Resistant strains of bacteria are rapidly emerging with increasing inappropriate use antibiotics rendering them less efficacious. Self-purchasing particularly for viral infections is a key driver use, especially in lower- and middle-income countries. There particular issue countries such as Pakistan. Consequently, there need to assess current rates self-purchasing reserve guide future policies.Assess the extent antibiotic sales without prescription urban areas Pakistan.A multicenter...
Abstract Primary effusion lymphoma (PEL) is an incurable, aggressive B-cell malignancy that develops rapid resistance to conventional chemotherapy. In efforts identify novel approaches block proliferation of PEL cells, we found sanguinarine, a natural compound isolated from the root plant Sanguinaria canadendid, inhibits cell and induces apoptosis in dose-dependent manner several lines. Our data show sanguinarine treatment cells results up-regulation death receptor 5 (DR5) expression via...
We provide evidence that curcumin, a natural compound isolated from rhizomes of plant Curcuma longa, induces apoptosis in several Burkitt's lymphoma cell lines expressing Bax protein (AS283A, KK124, and Pa682PB), whereas it has no effects with expression (BML895 CA46). Our data show curcumin treatment results down-regulation constitutive activation nuclear factor-kappaB (NF-kappaB) via generation reactive oxygen species where causes conformational changes leading to loss mitochondrial...
We have recently shown that deregulation PI3-kinase/AKT survival pathway plays an important role in pathogenesis of diffuse large B cell lymphoma (DLBCL). In attempt to identify newer therapeutic agents, we investigated the Resveratrol (trans-3,4', 5-trihydroxystilbene), a naturally occurring polyphenolic compound on panel B-cell (DLBCL) cells causing inhibition viability and inducing apoptosis.We action DLBCL found inhibited induced apoptosis by constitutively activated AKT its downstream...
Conclusions of research articles depend on bodies data that cannot be included in themselves. To share this is important for reasons both transparency and reuse. Science, Technology, Medicine journals have a role facilitating sharing, but by what mechanism not yet clear. The J ournal R esearch D ata ( o RD ) P roject was JISC oint I nformation S ystems C ommittee)‐funded feasibility study the potential central service journal policies. objectives identifying current state sharing policies...
The putative role of leptin and its receptor (Ob-R) in the pathogenesis various primary human malignancies has been reported; however, their papillary thyroid cancer (PTC) not yet evaluated. We investigated Ob-R a large tissue microarray cohort PTC followed by vitro studies using panel cell lines. overexpression was seen 80% PTCs significantly associated with poor disease-free survival (P=0.0235). that overexpressed showed aggressive phenotype characterized older age, extrathyroid extension,...
An output of the Data policy standardisation and implementation Interest Group (IG) Research Alliance (RDA) More journals publishers – funding agencies institutions are introducing research data policies. But as prevalence policies increases, there is potential to confuse researchers support staff with numerous or conflicting requirements. We define describe 14 features journal arrange these into a set six standard types tiers, which can be adopted by promote sharing in way that encourages...
Background: Salmonella enterica serotype Typhi and, to a lesser extent, serotypes Paratyphi A, B, and C, cause typhoid fever. Higher prevalence of is concern, particularly with remote areas in Astore valley. This study was conducted investigate the risk factors, vulnerable segments population, efficacy antibiotics against pathogen. Methods: Study District from October 2022-august 2023, which encompasses population exceeding 70,000 individuals residing across more than hundred communities....
S-phase kinase protein 2 (SKP2), an F-box protein, targets cell cycle regulators including cycle-dependent inhibitor p27Kip1 via ubiquitin-mediated degradation. SKP2 is frequently overexpressed in a variety of cancers. We investigated the role and its ubiquitin-proteasome pathway colorectal carcinoma using panel lines, clinical samples, NUDE mouse model. Using immunohistochemical analysis on large tissue microarray 448 inverse association expression with levels was seen. A cancer (CRC)...
Due to long duration of treatment and use several agents, tuberculosis can lead poor health related quality life among patients. Objective. The present study was designed assess pulmonary patients in Pakistan. Methodology. A descriptive cross-sectional design used. SF-36 self-administered a sample 382 receiving or directly observed types treatment, baseline, initial, continuous phase treatment. After data collection, cleaned, coded, statistically analyzed using SPSS version 21.0. Results....
Multiple myeloma (MM) is a malignant disorder characterized by proliferation of single clone plasma cells derived from β-cells in the bone marrow. It second most common adult hematological malignancy, and it cancer with skeletal components as its primary site. The purpose retrospective study was to assess profile, different biochemical parameters, serum electrophoresis patterns patients consistent clinical symptoms multiple myeloma.A 99 diagnosed carried out at Hematology Department Benghazi...
FoxM1 has been shown to play a critical role in the pathogenesis of various epithelial malignancies. However, its lymphoid malignancies not fully clarified. We, therefore, investigated expression large cohort diffuse B-cell lymphoma samples and panel cell lines.FoxM1 was series tissues tissue microarray format by immunohistochemistry. Apoptosis measured flow cytometry protein detected immunoblotting using lines following treatment with either pharmacological inhibitor or small interference...
Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers become more aggressive quickly develop resistance to therapy. Therefore targeting of these simultaneously can result efficient cell death cells. In this study we investigated co-expression Cox-2 FoxM1 a cohort colorectal carcinoma (CRC) samples also examined whether inhibition lead viability induction apoptosis lines vivo xenografts. Protein expression was determined...
Antimicrobial resistance is one of the biggest challenges to healthcare resulting in increased morbidity and mortality, associated with drug resistant infections. Community pharmacists (CPs) can play a key role antimicrobial stewardship (AMS) programs aid prudent use antibiotics, infection prevention control.The aim this study was assess perceptions CPs regarding their role, awareness, collaboration, facilitators barriers towards effective AMS practices Pakistan.ology: A descriptive,...