A5039675642- Sleep and related disorders
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- Mental Health Research Topics
- Digital Mental Health Interventions
- Youth Substance Use and School Attendance
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Obesity, Physical Activity, Diet
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Organ Donation and Transplantation
- Cardiovascular and Diving-Related Complications
- Spaceflight effects on biology
- Pain Management and Opioid Use
- Urban Agriculture and Sustainability
- Gestational Diabetes Research and Management
- High Altitude and Hypoxia
- Maternal Mental Health During Pregnancy and Postpartum
- Grief, Bereavement, and Mental Health
- Neuroscience and Music Perception
- Intergenerational Family Dynamics and Caregiving
- Restless Legs Syndrome Research
- Attachment and Relationship Dynamics
University of Oxford
2020-2024
Hinge Health
2020-2023
John Radcliffe Hospital
2023
Woolcock Institute of Medical Research
2013-2022
The University of Sydney
2013-2022
Neuroscience Institute
2021-2022
Oxford Centre for Computational Neuroscience
2020
University of Stirling
2018-2019
University of Glasgow
2013-2015
National Health and Medical Research Council
2013-2015
To investigate whether sleep restriction therapy (SRT) is associated with reduced objective total time (TST), increased daytime somnolence, and impaired vigilance. Within-subject, noncontrolled treatment investigation. Sleep research laboratory. Sixteen patients [10 female, mean age = 47.1 (10.8) y] well-defined psychophysiological insomnia (PI), reporting TST ≤ 6 h. Patients were treated single-component SRT over a 4-w protocol, sleeping in the laboratory for 2 nights prior to initiation 3...
Background Cognitive behavioral therapy (CBT) is an efficacious intervention for generalized anxiety disorder (GAD). Digital CBT may provide a scalable means of delivering at population level. We investigated the efficacy novel digital program in those with GAD outcomes anxiety, worry, depressive symptoms, sleep difficulty, wellbeing, and participant-specific quality life. Methods This online, two-arm parallel-group superiority randomized controlled trial compared waitlist control 256...
Summary Insomnia predicts the onset of depression, commonly co‐presents with depression and often persists following remission. However, these conditions can be challenging to treat concurrently using depression‐specific therapies. Cognitive behavioural therapy for insomnia may an appropriate treatment improve both depressive symptoms. We examined effects a fully‐automated digital cognitive intervention ( Sleepio ) on symptoms, mediating role sleep improvement symptoms in participants from...
Randomized prospective trial.To compare the efficacy of intravenous analgesia with single and dual continuous epidural (CEA) in patients adolescent idiopathic scoliosis (AIS) undergoing posterior spinal fusion instrumentation (PSIF).Pain management after (PSF) for AIS is challenging. Although patient-controlled (PCA) used most commonly, CEA has been found to be safe effective. Recently, use 2 catheters thought more effective than a catheter, although using not directly compared...
To evaluate changes in rates of family physician (FP) management insomnia Australia from 2000-2015.The Bettering the Evaluation And Care Health (BEACH) program is a nationally representative cross-sectional survey 1,000 newly randomly sampled physicians' activity per year, who each record details 100 consecutive patient encounters. This provided records approximately 100,000 encounters year. We identified all with patients older than 15 years where or difficulty sleeping was managed and...
To empirically derive and evaluate potential clusters of Insomnia Disorder through cluster analysis from polysomnography (PSG). We hypothesized that would differ on neurocognitive performance, sleep-onset measures quantitative (q)-EEG heart rate variability (HRV).Research volunteers with (DSM-5) completed a assessment overnight PSG total sleep time (TST), wake after onset (WASO), latency (SOL) were used to determine clusters.From 96 Disorder, derived at least two objective parameters: normal...
Abstract This study investigated whether providing sham feedback about sleep to individuals with insomnia influenced daytime symptom reports, sleep‐related attentional bias and psychomotor vigilance. Sixty‐three participants meeting DSM‐5 criteria for disorder were recruited from the community. Following baseline assessments actigraphy briefing, randomised receive next‐day on quality (“positive” vs. “negative” efficiency condition). Feedback was delivered at habitual rise‐time using an...
Abstract Study Objectives To examine the cost-effectiveness and potential net monetary benefit (NMB) of a fully automated digital cognitive behavioral therapy (CBT) intervention for insomnia compared with no treatment in United States (US). Similar relative comparisons were made pharmacotherapy clinician-delivered CBT (individual group). Methods We simulated Markov model 100,000 individuals using parameters calibrated from literature including direct (treatment) indirect costs (e.g....
Purpose: We aimed to adapt the Turkish Sleep Condition Indicator (SCI) version and examine its psychometric properties among general population. Methods: This study was a cross-sectional study. The item-total correlation, standard error of measurement, Cronbach's α, McDonald's ω were used for internal consistency. ran confirmatory factor analysis (CFA) network confirm structure. Multigroup CFA run assess measurement invariance across gender, whether clinical insomnia or not, poor sleep...
Summary This study profiles changes in self‐reported daytime functioning during sleep restriction therapy ( SRT ) for insomnia. Ecological momentary assessment (EMA) captured point‐in‐time symptomatology to map the time–course of symptoms. We hypothesized a deterioration (week 1) followed by improvements at week 3 relative baseline. Nine patients with psychophysiological insomnia completed D aytime I nsomnia S ymptom cale DISS rise‐time, 12:00 hours, 18:00 hours and bedtime 1 before weeks ....
In this retrospective cohort study, we describe acceptability, tolerability and potential efficacy of cognitive behavioural therapy (CBT) in Insomnia Disorder subtypes, derived from polysomnography (PSG): insomnia with normal-sleep duration (I-NSD) short-sleep (I-SSD). All research volunteers were offered access to digital CBT, single component sleep restriction face-to-face group CBT. Follow-up occurred at three months post-treatment using the severity index (ISI). 96 participants (61...
Insomnia is a highly prevalent sleep disorder with strong bidirectional associations depressive symptoms. The circadian preference for eveningness has been shown to be associated symptoms in insomnia and other mental health conditions. However, there lack of studies investigating whether objective measures, such as dim light melatonin onset (DLMO) or polysomnographic (PSG) sleep, are Therefore, we investigated the between subjective measures (questionnaires assessing anxiety, quality...
Background: This paper looks at attrition in relation to deprivation and type of therapy – CBT or person-centred counselling. Method: Case notes all those referred a 4-month period ( n = 497) were assessed for who failed opt-in; opted-in but attend first appointment attended subsequently dropped-out. Results: Significant numbers opt-in, dropped out during therapy. There no differences between PCT. Those from the most deprived areas less likely opt-in. Conclusions: We need develop better...
Objectives The aim of this preliminary study was to evaluate if Sleep Restriction Therapy for insomnia is associated with modifications physiological arousal, indexed through overnight measures plasma cortisol concentrations and core body temperature. Methods In a pre-to-post open label design, eleven patients chronic severe Psychophysiological Insomnia underwent 5 weeks Therapy. Results Eight (73%) out 11 consented completed therapy showed decrease in severity treatment (mean (SD): 18.1...
Abstract Digital cognitive behavioural therapy (dCBT) is an effective treatment for chronic insomnia and also improves well‐being quality of life (QoL). We assessed whether these benefits are sustained if the effects dCBT extend to use sleep medication healthcare. In total 1,711 adults (48.0 ± 13.8 years, 77.6% female) with complaints participated in a previously published randomized controlled trial (ISRCTN 60530898) comparing ( n = 853) hygiene education (SHE, 858). At weeks 0, 4, 8, 24,...
To evaluate brain metabolites in objective insomnia subtypes defined from polysomnography (PSG): with short sleep duration (I-SSD) and normal (I-NSD), relative to good sleeping controls (GSCs). PSG empirically grouped patients into I-SSD (n = 12: mean [SD] total time [TST] 294.7 minutes [30.5]) or I-NSD 19: TST 394.4 [34.9]). 1H magnetic resonance spectroscopy (MRS) acquired the left occipital cortex (LOCC), prefrontal cortex, anterior cingulate was used determine levels of creatine,...