A5053068360- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Hepatocellular Carcinoma Treatment and Prognosis
- Hemodynamic Monitoring and Therapy
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Respiratory Support and Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cancer Genomics and Diagnostics
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Advanced MRI Techniques and Applications
- Thermoregulation and physiological responses
- Immunotherapy and Immune Responses
- Climate Change and Health Impacts
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cerebrospinal fluid and hydrocephalus
- Genomic variations and chromosomal abnormalities
- Metastasis and carcinoma case studies
- BRCA gene mutations in cancer
- Renal function and acid-base balance
- Ethics and Legal Issues in Pediatric Healthcare
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
Atlantic Health System
2025
Columbia University
2025
University of Freiburg
2014-2024
University Medical Center Freiburg
2013-2020
Fraunhofer Project Centre Wolfsburg
2008-2018
CeGaT (Germany)
2013-2016
Martin Luther University Halle-Wittenberg
1996-2016
Genomics (United Kingdom)
2013
University of Tübingen
2012
Laboklin (Germany)
2011
Studies of genomic copy number variants (CNVs) have identified genes associated with autism spectrum disorder (ASD) and intellectual disability (ID) such as NRXN1 , SHANK2 SHANK3 PTCHD1 . Deletions been reported in however there has little information available regarding the clinical presentation these individuals. Herein we present 23 individuals deletions or truncating mutations detailed phenotypic descriptions. The results suggest that disruption coding region may subtle dysmorphic...
In order to optimize therapy for the injured brain it is desirable continuously monitor substrate delivery in critically ill patient. Interruption of a major factor great vulnerability ischemic damage, which affects majority patients after severe head injury, stroke or subarachnoid hemorrhage. An approach protecting during ischemia increase oxygen via residual blood flow through tissue. Hypothermia also an important means cells from deleterious effects ischemia, because reduces metabolic...
Nitrogenated multilayer graphene is prepared from renewable feedstocks in a cost-efficient route to meet the emerging demand for graphene-based materials.
Brain tissue oxygen monitoring (PtiO2 (Neurotrend, Codman, Germany) was employed in addition to standard intracranial pressure (ICP) and cerebral perfusion (CPP) seven patients with severe neuronal damage of heterogeneous etiology. The correlation between PtiO2 changes CPP fluctuations during periods 30 minutes were analyzed, when above 70 mmHg lower than 100 mmHg. A new ratio, the CPP-oxygen-reactivity (COR) index calculated as COR=ΔptiO2%/ΔCPP%. patient COR values compared those found...
The purpose of the present experimental study was to determine feasibility and usefulness brain temperature measurement (T(br)) calculated difference between arterial blood (DeltaT(br-a)) in uninjured during variations cerebral perfusion pressure (CPP) concomitant changes regional flow (rCBF).Nine anaesthetized pigs were subjected controlled CPP decrease assess lower autoregulation threshold. A parenchymal intracranial (ICP) sensor combined with a microthermistor for measurement,...
Local brain tissue oxygenation (ptiO2) and global cerebrovenous hemoglobin saturation (SJO2) are increasingly used to continuously monitor patients after severe head injury (SHI). In patients, simultaneous local oxygen measurements of these types have shown different results regarding the comparability findings during changes in CPP ICP. This is contrast theoretical expectations. The aim this study was compare PtiO2 measurement with partial pressure (pcvO2) an animal intracranial model. To...
Introduction: The clinical use of brain tissue oxygen measurement in patients with severe head injury is increasing. It important to compare the findings cerebrovenous blood oximetry, obtain normal values and find out limitations method. We evaluated a newly available multisensor probe simultaneously sagittal sinus porcine animal model. Methods: placed Paratrend 7©-probe (BSL, High Wycombe, UK) left frontoparietal white matter measured pO2 (ptiO2), pCO2 (ptiCO2), pH temperature while...
Colorectal cancer (CRC) with hepatic (CRLM) and pulmonary metastases (CRLU) presents a significant clinical challenge, leading to poor prognosis. Surgical resection of these remains controversial because limited evidence supporting its long-term benefits. To evaluate the impact surgical both on survival in patients multivisceral metastatic colorectal cancer, this retrospective cohort study included 192 UICC stage IV CRC treated at high-volume academic center.
The objective of the first part this study was to use an animal model investigate relationship between temperature in cerebrovenous compartment and cerebral perfusion pressure. In second study, examine influence hyperventilation hypothermia on jugular bulb body patients undergoing elective neurosurgery. Intracranial pressure increased artificially by inflating infratentorial supracerebellar placed balloon catheter nine pigs under general anesthesia. Temperature monitored thermocouples...
Bei Patienten nach einem schweren Schädel-Hirn-Trauma (SHT) wird die loko-regionale Hirngewebeoxymetrie (ptiO2) mittels polarographischer Clark-Elektroden zunehmend zur Überwachung der zerebralen Oxygenierung angewandt. In vorliegenden Studie untersuchten wir den Verlauf ptiO2 Messung während eines normobarischen Hyperoxieversuchs mit 100% Sauerstoffbeatmung (O2rea) in Tiermodell des Schweins und bei SHT. Die Ergebnisse Patientenmessung wurden dem Patienten-Outcome 3 Monaten...